The Authors Reply:

Sakaguchi, Yusuke; Fujii, Naohiko; Tanaka, Shōji; Hayashi, Terumasa; Rakugi, Hiromi; Iseki, Kunitoshi; Tsubakihara, Yoshiharu; Isaka, Yoshitaka

doi:10.1038/ki.2014.176

Cited by 1 publication

(2 citation statements)

References 7 publications

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“…A large study in Japan showed that there was a relationship between low magnesium concentrations and mortality, which means that hypomagnesemia was an important predictor of cardiovascular or non-cardiovascular mortality. Hypermagnesemia is also associated with higher mortality, but the intensity of correlation was smaller than that of hypomagnesemia (Sakaguchi et al, 2014).…”

Section: Discussionmentioning

confidence: 88%

“…Mg 2+ was strongly linked to the cardiovascular system, inflammation, insulin resistance, and metabolic syndrome (Belin and He, 2007). Some studies found that magnesium deficiency is associated with an increased risk of hypertension (Liu and Dudley, 2020), diabetes (Piuri et al, 2021), and mortality (Sakaguchi et al, 2014). As mentioned previously, Mg 2+ is an essential cofactor for many enzymes involved in glucose metabolism.…”

Section: Discussionmentioning

confidence: 90%

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A multi-center study on the association between serum magnesium levels and allostatic load in hemodialysis patients

Zhang

Yang

et al. 2022

Front. Physiol.

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Objective: Serum magnesium (Mg2+) levels are associated with insulin resistance, hypertension, lipid abnormalities, and inflammation. However, limited studies have indicated the relationship between Mg2+ and multiple system indexes. The purpose of this study was to investigate the association between Mg2+ and allostatic load (AL) in hemodialysis patients.Methods: A cross-sectional survey was conducted on hemodialysis patients from different centers in Anhui Province, China, between January and December 2020. A total of 3,025 hemodialysis patients were recruited. Their clinical data were measured before hemodialysis. Information was collected by an online self-reported questionnaire and medical record. Serum Mg2+ was divided into three groups by tertiles. A score of AL greater than or equal to 3 was defined as high AL. A binary logistic regression model was applied to examine the relationship between serum Mg2+ and AL.Results: A total of 1,222 patients undergoing hemodialysis were included, 60% of whom were males (733/1,222). The mean (standard deviation) age of patients was 55.90 (12.75). The median level of serum Mg2+ was 1.22 mmol/L. The rate of high AL levels was 23.4%. Serum Mg2+ was negatively correlated with body mass index, fasting blood glucose (Glu), and C-reactive protein and positively correlated with high-density lipoprotein, low-density lipoprotein, total cholesterol, diastolic blood pressure (DBP), and serum phosphorus. After adjusting for gender, anxiety, diabetes, family residence, lipid-lowering agents, antihypertensive medications, albumin, and Glu, the binary logistic regression model showed that patients with lower levels of serum Mg2+ were more likely have high AL (OR for the T1 group of serum Mg2+:1.945, 95% CI: 1.365–2.773, and OR for the T2 group of serum Mg2+:1.556, 95% CI: 1.099–2.201).Conclusion: Our data support the hypothesis that higher serum Mg2+ concentrations may contribute to lower health risk in hemodialysis populations. Further randomized controlled trials and cohort studies are warranted to verify whether Mg2+ supplementation could be part of routine examinations in hemodialysis populations.

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Section: Discussionmentioning

confidence: 88%