The authors' reply

1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials Chemistry

“…Though sulfonamides incorporating with a 1,3,4-thiadiazole nucleus showed outstanding inhibitory activities on different isoforms of carbonic anhydrases, isozyme-specific inhibitors were hardly discovered, , which we also mentioned earlier in this review. In addition, thiadiazole derivatives targeted various enzymes, that is, aminopeptidase N inhibitors, tyrosinase inhibitors, phosphodiesterases PDE7 inhibitors, , neutral endopeptidase inhibitors for treatment of female sexual arousal disorder, , c-jun N-terminal kinase inhibitors, fatty acid amide hydrolase (FAAHa) inhibitors, matrix metalloproteinase inhibitors, inhibitors of both neuronal and inducible nitric oxide synthase, as well as obesity-associated enzymes and receptors including cannabinoid-1 receptor antagonist, mitochondrial CA V, and VB, , and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors and C -aryl glucoside SGLT2 inhibitors for treatment of diabetes and dyslipidemia. , Thiadiazole fungicide was also reported to have an effect on thyroid and hepatic enzyme activity in juvenile female rats . Thiadiazoles acted as antagonist of human adenosine A3 receptor and the orphan nuclear receptor estrogen-related receptor α .…”