2022
DOI: 10.1101/2022.09.14.507907
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The autism-associated Meis2 gene is necessary for cardiac baroreflex regulation in mice

Abstract: Recent understanding of Autism Spectrum Disorder (ASD) showed that peripheral primary mechanosensitive neurons involved in touch sensation and central neurons affected in ASD share transcriptional regulators. Mutant mice for ASD-associated transcription factors exhibit impaired primary tactile perception, and restoring those genes specifically in primary sensory neurons rescue some of the anxiety-like behavior and social interaction defects. Interestingly, peripheral mechanosensitive sensory neurons also proj… Show more

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