The Autism Speaks Autism Treatment Network Registry Data: Opportunities for Investigators

Murray, Donna S.; Fedele, Angie; Shui, Amy; Coury, Daniel L.

doi:10.1542/peds.2015-2851e

Cited by 30 publications

(24 citation statements)

References 16 publications

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“…With this in mind, two recent studies used Autism Speaks’ Autism Treatment Network (ATN) to examine the potential relationship between sensory abnormalities and sleep disturbances in autism. The ATN is a large national database [ 28 ] containing a wide variety of behavioral information from children with autism, which includes the Child Behavior Checklist (CBCL) [ 29 ], Short Sensory Profile [ 30 ], and a short, 23 item version, of the Children’s Sleep Habits Questionnaire (CSHQ) [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Sleep disturbances are associated with specific sensory sensitivities in children with autism

et al. 2018

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BackgroundSensory abnormalities and sleep disturbances are highly prevalent in children with autism, but the potential relationship between these two domains has rarely been explored. Understanding such relationships is important for identifying children with autism who exhibit more homogeneous symptoms.MethodsHere, we examined this relationship using the Caregiver Sensory Profile and the Children’s Sleep Habits Questionnaire, which were completed by parents of 69 children with autism and 62 age-matched controls.ResultsIn line with previous studies, children with autism exhibited more severe sensory abnormalities and sleep disturbances than age-matched controls. The sleep disturbance scores were moderately associated with touch and oral sensitivities in the autism group and with touch and vestibular sensitivities in the control group. Hypersensitivity towards touch, in particular, exhibited the strongest relationship with sleep disturbances in the autism group and single-handedly explained 24% of the variance in total sleep disturbance scores. In contrast, sensitivity in other sensory domains such as vision and audition was not associated with sleep quality in either group.ConclusionsWhile it is often assumed that sensitivities in all sensory domains are similarly associated with sleep problems, our results suggest that hypersensitivity towards touch exhibits the strongest relationship with sleep disturbances when examining children autism. We speculate that hypersensitivity towards touch interferes with sleep onset and maintenance in a considerable number of children with autism who exhibit severe sleep disturbances. This may indicate the existence of a specific sleep disturbance mechanism that is associated with sensitivity to touch, which may be important to consider in future scientific and clinical studies.

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Section: Introductionmentioning

confidence: 99%

Sleep disturbances are associated with specific sensory sensitivities in children with autism

et al. 2018

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“…One recommendation is for centers that document utilization information to adopt a validated instrument to allow comparison across study centers and to identify strategies to ensure that areas with low resource utilization are included in research studies. Research on ASD using registries provides a number of strengths, but limitations are present and should be acknowledged (40).…”

Section: Discussionmentioning

confidence: 99%

Parent-Reported Use of Interventions by Toddlers and Preschoolers With Autism Spectrum Disorder

Payakachat

Tilford

Kuhlthau

2018

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“…The ATN registry is briefly summarized here and has been previously described in greater depth. 27,28 The ATN sites represent a network of academicaffiliated autism centers of excellence in the United States and Canada committed to a comprehensive evaluation and care program for children with ASD. The ATN registry includes data on a subset of children with ASD who received care at a network clinical center.…”

Section: Data Source and Samplementioning

confidence: 99%

“…Individual sites enrolled a convenience sample of children on the basis of inclusion and exclusion criteria. 27,28 Site patients were eligible to enroll if they were aged ,17.6 years and met diagnostic cutoffs for ASD as determined by the Autism Diagnostic Observation Schedule (ADOS) and the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition or the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. 29,30 Exclusion criteria included a medical condition that precluded valid diagnostic testing (eg, blindness), and parents had to be fluent in English or Spanish.…”

Section: Data Source and Samplementioning

confidence: 99%

Service Use Classes Among School-aged Children From the Autism Treatment Network Registry

Lindly

Chan²,

Levy

et al. 2020

Pediatrics

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BACKGROUND AND OBJECTIVES: Use of specific services may help to optimize health for children with autism spectrum disorder (ASD); however, little is known about their service use patterns. We aimed to (1) define service use groups and (2) determine associations of sociodemographic, developmental, behavioral, and health characteristics with service use groups among schoolaged children with ASD. METHODS: We analyzed cross-sectional data on 1378 children aged 6 to 18 years with an ASD diagnosis from the Autism Speaks Autism Treatment Network registry for 2008-2015, which included 16 US sites and 2 Canadian sites. Thirteen service use indicators spanning behavioral and medical treatments (eg, developmental therapy, psychotropic medications, and special diets) were examined. Latent class analysis was used to identify groups of children with similar service use patterns. RESULTS: By using latent class analysis, school-aged children with ASD were placed into 4 service use classes: limited services (12.0%), multimodal services (36.4%), predominantly educational and/or behavioral services (42.6%), or predominantly special diets and/or natural products (9.0%). Multivariable analysis results revealed that compared with children in the educational and/or behavioral services class, those in the multimodal services class had greater ASD severity and more externalizing behavior problems, those in the limited services class were older and had less ASD severity, and those in the special diets and/or natural products class had higher income and poorer quality of life. CONCLUSIONS: In this study, we identified 4 service use groups among school-aged children with ASD that may be related to certain sociodemographic, developmental, behavioral, and health characteristics. Study findings may be used to better support providers and families in decision-making about ASD services. WHAT'S KNOWN ON THIS SUBJECT: Myriad services exist for children with autism spectrum disorder (ASD). Some researchers have examined the use of individual services, the number of services used, and weekly treatment hours among children with ASD. Little is known, however, about service use patterns among children with ASD. WHAT THIS STUDY ADDS: In this study, we identified 4 distinctive service use classes among a large sample of school-aged children with ASD across North America. Service use classes included limited services, multimodal services, predominantly educational and/or behavioral services, and predominantly special diets and/or natural products.

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The Autism Speaks Autism Treatment Network Registry Data: Opportunities for Investigators

Cited by 30 publications

References 16 publications

Sleep disturbances are associated with specific sensory sensitivities in children with autism

Sleep disturbances are associated with specific sensory sensitivities in children with autism

Parent-Reported Use of Interventions by Toddlers and Preschoolers With Autism Spectrum Disorder

Service Use Classes Among School-aged Children From the Autism Treatment Network Registry

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