The Autologous Mixed Lymphocyte Reaction

Gupta, Sudhir

doi:10.1007/978-1-4613-2493-5_3

Cited by 2 publications

(1 citation statement)

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“…4. Eine Reduktion der ConA-induzierbaren T-Zell-Suppression und eine verminderte autologe gemischte Lymphozyten-Reaktion (AMLR) werden seit langem als Ausdruck eines Suppressionsverlustes bei verschiedenen Autoimmunerkrankungen gewertet (15,16). In "limiting dilution" Kulturen autoreaktiver T-Zellen von RA und Borreliose-Patienten fanden sich mit Synovia Lymphocyten stets "single hit" Kinetiken, was auf fehlende Suppression hindeutet (28,37).…”

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1989

LaboratoriumsMedizin

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Based on clinical findings and joint morphology recent immunopathologic concepts of the development of inflammatory joint diseases are discussed. Besides an immunogenetic predisposition (B27, DR4) joint infiltrating helper T cells are thought to play a major pathogenetic role. The distinction of naive (CD45R+) and memory helper T cells (CDw29+) is discussed in the context of rheumatic joint disease. To initiate a rheumatic joint disease arthritogenic structures capable of stimulating helper T cells are required. Surprisingly a considerable number of these potentially arthritogenic antigens exhibit a structural homology with sereval bacterial and viral proteins ("molecular mimicry").

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1989

LaboratoriumsMedizin

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Augmented interleukin‐1 production and hla–dr expression in the synovium of rheumatoid arthritis patients

Miyasaka

Sato

Goto

et al. 1988

Arthritis & Rheumatism

205

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Potent interleukin‐1 (IL‐1) activity was detected in culture supernatants from synovium, obtained by arthroscopy, from rheumatoid arthritis (RA) patients but not from non‐RA patients. Production of IL‐1 by RA synovium correlated well with findings of inflammation on arthroscopy and HLA–DR expression in immunohistochemical staining. Furthermore, there was a positive correlation between IL‐1 production from RA synovium and joint changes detected on roentgenograms. These findings strongly suggest that IL‐1 might play an important role in the joint destruction in RA.

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The Autologous Mixed Lymphocyte Reaction

Cited by 2 publications

References 97 publications

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Augmented interleukin‐1 production and hla–dr expression in the synovium of rheumatoid arthritis patients

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