2022
DOI: 10.1371/journal.pone.0276879
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The autophagic protein p62 is a target of reactive aldehydes in human and murine cholestatic liver disease

Abstract: Inflammatory cholestatic liver diseases, including Primary Sclerosing Cholangitis (PSC), are characterized by periportal inflammation with progression to cirrhosis. The objective of this study was to examine interactions between oxidative stress and autophagy in cholestasis. Using hepatic tissue from male acute cholestatic (bile duct ligated) as well as chronic cholestatic (Mdr2KO) mice, localization of oxidative stress, the antioxidant response and induction of autophagy were analyzed and compared to human PS… Show more

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Cited by 6 publications
(2 citation statements)
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“…It is noteworthy that this type of regeneration, involving ductal response and differentiation of cells from progenitors or cholangioblasts to hepatocytes, is not commonly observed in all other scenarios of hepatocyte loss, such as partial hepatectomy, CCl4 or DDC diet-induced injury, but has been demonstrated in cases of choline-deficient-ethioninesupplemented diet, specific genetic perturbations, in cholestatic injury, and senescent hepatocytes-induced injury [60][61][62][63][64]. Ductal reactions play an increasingly vital role in understanding hepatic stem and progenitor cells during liver regeneration, the processes driving hepatic fibrosis, and the development of hepatobiliary carcinogenesis [65].…”
Section: Discussionmentioning
confidence: 99%
“…It is noteworthy that this type of regeneration, involving ductal response and differentiation of cells from progenitors or cholangioblasts to hepatocytes, is not commonly observed in all other scenarios of hepatocyte loss, such as partial hepatectomy, CCl4 or DDC diet-induced injury, but has been demonstrated in cases of choline-deficient-ethioninesupplemented diet, specific genetic perturbations, in cholestatic injury, and senescent hepatocytes-induced injury [60][61][62][63][64]. Ductal reactions play an increasingly vital role in understanding hepatic stem and progenitor cells during liver regeneration, the processes driving hepatic fibrosis, and the development of hepatobiliary carcinogenesis [65].…”
Section: Discussionmentioning
confidence: 99%
“…Western blots were performed liver homogenate using 30μg of protein per lane as previously described [ 37 , 38 ]. The antibodies used in this study are listed in Table 2 .…”
Section: Methodsmentioning
confidence: 99%