The availability of <scp>HEPA</scp>‐filtered rooms and the incidence of pneumonia in patients after haematopoietic stem cell transplantation (<scp>HSCT</scp>): results from a prospective, multicentre, eastern <scp>E</scp>uropean study

Vokurka, Samuel; Bystřická, Eva; Svoboda, Tomáš; Gorican, I K S; Sever, Matjaž; Mazur, Ewa; Kopińska, Anna; Pavlicová, Vladislava; Mocanu, Otilia; Tănase, Alina; Ghelase, R; Zítková, Marie; Labudíková, Monika; Raida, Ludek; Hrabánková-Navrátilová, Darja; Bocková, Jana

doi:10.1111/jocn.12286

Cited by 24 publications

(26 citation statements)

References 8 publications

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“…Patients’ rooms should be equipped with air-filtered systems to keep spore counts low and, thus, preventing nosocomial fungal diseases (BII ) [ 5 – 9 ]. Further, nearby construction activities should be kept to a minimum (AII) .…”

Section: General Precautionsmentioning

confidence: 99%

Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016

Ullmann¹,

et al. 2016

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Infectious complications after allogeneic haematopoietic stem cell transplantation (allo-HCT) remain a clinical challenge. This is a guideline provided by the AGIHO (Infectious Diseases Working Group) of the DGHO (German Society for Hematology and Medical Oncology). A core group of experts prepared a preliminary guideline, which was discussed, reviewed, and approved by the entire working group. The guideline provides clinical recommendations for the preventive management including prophylactic treatment of viral, bacterial, parasitic, and fungal diseases. The guideline focuses on antimicrobial agents but includes recommendations on the use of vaccinations. This is the updated version of the AGHIO guideline in the field of allogeneic haematopoietic stem cell transplantation utilizing methods according to evidence-based medicine criteria.

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Section: General Precautionsmentioning

confidence: 99%

Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016

Ullmann¹,

et al. 2016

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“…Protective isolation denotes a range of practices used in hospitals to lower the infection risk of patients with severe immunosuppression, including patients undergoing haematopoietic stem cell transplantation (HSCT) (Styczynski et al, 2018). In fact, HSCT patients can develop pancytopenia after a conditioning regimen (Holy & Matouskova, 2012;Saria, 2011;Schlesinger, Paul, Gafter-Gvili, Rubinovitch, & Leibovici, 2009;Vokurka et al, 2013;Yokoe et al, 2009). Isolation measures aim to protect patients by limiting their physical contact with other people.…”

Section: Introductionmentioning

confidence: 99%

Factors influencing the perception of protective isolation in patients undergoing haematopoietic stem cell transplantation: A multicentre prospective study

et al. 2019

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Objectives To identify which factors can influence the patients’ perception of protective isolation following Haematopoietic Stem Cell Transplantation (HSCT). Methods This is a prospective study conducted in 10 Italian centres, members of the Italian Group of stem cell transplant (GITMO). Patients’ perception of protective isolation was assessed using the ISOLA scale between 7 and 9 days post‐transplant. Statistical linear regression analysis was performed. Results The participants were 182 adult patients receiving autologous (48%) or allogeneic (52%) HSCT in protective isolation. Male sex (β = .152), education level (β = −.245), double room (β = .186), satisfaction with visiting hours (β = −.174) and emotional support from nurses (β = −.169) were independently associated with isolation‐related suffering. Significant predictors of the relationship with oneself included body temperature (β = −.179), fatigue (β = −.192) and emotional support from nurses (β = −.292). Factors independently associated with the relationship with others were education (β = −.230), chemotherapy cycles (β = −.218), pain (β = .150) and satisfaction with visiting hours (β = −.162). Conclusion Healthcare providers should pay greater attention in caring for those patients who are at risk for a negative isolation experience. Nurses should provide emotional support.

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“…Patients undergoing haematopoietic stem cell transplantation (HSCT) can receive hospital care in protective isolation until full neutrophil recovery, as they become pancytopenic after conditioning regimen and thereby need to lower their infection risk (Holy & Matouskova, 2012;Saria, 2011;Schlesinger, Paul, Gafter-Gvili, Rubinovitch, & Leibovici, 2009;Vokurka et al, 2013;Yokoe et al, 2009). Protective isolation includes behavioural measures, such as the use of face masks or cleaning routine, and structural measures, such as positive pressure and anteroom (Kruger et al, 2001;Tecchio et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Development and initial validation of a questionnaire to assess patients’ perception of protective isolation following haematopoietic stem cell transplantation

et al. 2018

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The aim of this study was to develop and psychometrically test a questionnaire assessing patients’ perception of protective isolation following haematopoietic stem cell transplantation (HSCT). The conceptual framework for developing the questionnaire was a three‐dimensional model that emerged from a metasynthesis: isolation‐related suffering, relationship with oneself and relationship with others. Item selection was performed through a focus group, comparison with the findings of two phenomenological studies, and content validity with 22 experts. Cognitive interviews with five patients were used to verify face validity. A validation study was conducted in 10 Italian centres, all members of the Italian Group of stem cell transplant (GITMO). Patients completed the questionnaires between 7 and 9 days post‐transplant. Dimensionality was tested through exploratory factor analysis (EFA). A total of 17 items yielded a content validity index (CVI) of 0.88. Participants included 186 adult patients receiving autologous (48%) or allogeneic (52%) HSCT in protective isolation. The EFA yielded a three‐factor solution, explaining 55% of the variance. The scale showed adequate psychometric properties, with the exception of three items, which were eliminated. Future studies should test the psychometric properties of the questionnaire through confirmatory factor analysis and verify its transcultural validity.

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The availability of HEPA‐filtered rooms and the incidence of pneumonia in patients after haematopoietic stem cell transplantation (HSCT): results from a prospective, multicentre, eastern European study

Abstract: Autologous HSCT transplantation may safely be performed without HEPA filtration. HEPA filtration might be preferable in patients undergoing allogeneic transplantation.

Cited by 24 publications

References 8 publications

Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016

Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016

Factors influencing the perception of protective isolation in patients undergoing haematopoietic stem cell transplantation: A multicentre prospective study

Development and initial validation of a questionnaire to assess patients’ perception of protective isolation following haematopoietic stem cell transplantation

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