The avian microcrystal arthritis I. Simultaneous recording of nociception and temperature effect in the inflamed joint

Brune, Kay; Walz, D.; Bücher, K

doi:10.1007/bf01965488

Cited by 25 publications

(16 citation statements)

References 12 publications

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“…Nociception and temperaturerise as parameters of this inflammation show similar timecourses as described for pigeons [4]. LP-injections also caused moderate signs of inflammation.…”

Section: Introductionsupporting

confidence: 54%

“…This can be taken as a symptom of nociception. One-leg standing was recorded as described previously for pigeons [4]. For evaluation of the standing behaviour see Figure 1.…”

Section: Materk~is and Methodsmentioning

confidence: 99%

“…In previous publications [4,5] we described a model of acute inflammation: the arthritis elicited in pigeons by injections ofurate crystals (UC). With this model we simultaneously recorded two parameters of inflammation: nociception and temperature-rise in the inflamed tissue [4].…”

Section: Introductionmentioning

confidence: 99%

“…With this model we simultaneously recorded two parameters of inflammation: nociception and temperature-rise in the inflamed tissue [4]. Nociception was taken as a central and temperature-rise as peripheral parameter of inflammation.…”

Section: Introductionmentioning

confidence: 99%

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The avian microcrystal arthritis III. invasion and enzyme-release from leukocytes at the site of inflammation

Brune

Glatt

1974

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An attempt was made to find a suitable parameter for the cellular events taking place at the site of inflammation of the avian mieroerystal arthritis. For that purpose, the arthritis elicited by injections of urate crystals (UC) in pigeons was adopted for chicken. In the larger animals it was possible to obtain sufficient joint fluid for histological and biochemical investigation. In order to find a parameter specific for the UC arthritis, the histological and biochemical findings were compared with the time-course of noeiception and temperature-rise of the inflammed joints and with results from animals having received intra-artieular injections of Latex particles (LP).It was found that UC-injections cause an inflammation in intertarsal joints of chicken. Nociception and temperaturerise as parameters of this inflammation show similar timecourses as described for pigeons [4]. LP-injections also caused moderate signs of inflammation. They appeared later and only in some animals. However, the time-course of appearance of polymorphonuclear leukocytes (PMN) and lysozyme in the joint fluid was the same in UC-and LPtreated animals. Only beta-glucuronidase-activity was found to reflect the other two parameters of inflammation. From the results it is concluded that the beta-glucuronidase activity in the joint fluids might be used as an enzymatic parameter of this inflammation. In addition, doubts are raised against the proposed mediator function of PMN.

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“…Nociception and temperaturerise as parameters of this inflammation show similar timecourses as described for pigeons [4]. LP-injections also caused moderate signs of inflammation.…”

Section: Introductionsupporting

confidence: 54%

“…This can be taken as a symptom of nociception. One-leg standing was recorded as described previously for pigeons [4]. For evaluation of the standing behaviour see Figure 1.…”

Section: Materk~is and Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The avian microcrystal arthritis III. invasion and enzyme-release from leukocytes at the site of inflammation

Brune

Glatt

1974

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“…Painful inflammation of the ankle joint produced by sodium urate crystal injection resulted in one-legged standing in the chicken and pigeon (Floersheim et al, 1973;Brune et al, 1974). One-legged standing requires complex postural changes involving muscles innervated from nerves in both the lumbar and sacral plexuses (Baumel, 1975).…”

Section: Brainstemmentioning

confidence: 98%

Projections of ankle joint afferents to the spinal cord and brainstem of the chicken (Gallus G. domesticus)

Gentle

Hunter

Sterling

1995

J of Comparative Neurology

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The projections of the ankle joint capsule afferents were studied by transganglionic transport of horseradish peroxidase injected directly into the ankle joint. The number and size of the labelled dorsal root ganglion cells were measured from synsacral nerves 2-9. In the dorsal root ganglia, all sizes of sensory neurones were labelled, and the largest number of labelled cells was in ganglia 5-7. The extensive sympathetic innervation of the ankle joint was identified by the large number of cell bodies labelled in the sympathetic ganglia of the paravertebral chain. Labelled afferent fibres projected to the spinal cord from the 2nd to the 8th synsacral nerves, with the rostral projection mainly via Lissauer's tract and the dorsal funiculus. Terminal labelling in the dorsal horn was identified in laminae I-III and VI, with a slight projection to V. Two areas of dense labelling, which did not correspond with the largest number of labelled dorsal root ganglion cells, were identified. A rostral area with the highest density of label was observed at the level of synsacral nerves 3-4 and a second slightly less dense area between synsacral nerves 7-8. In the caudal medulla, diffuse terminal labelling was observed in the nucleus gracilis et cuneatus, nucleus of the tractus solitarius, and the nucleus cuneatus externus. These results are discussed in a comparative context to identify similarities and differences between different primary afferent projections in birds and mammals and to highlight the possible functional significance of the avian articular afferent projection.

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Inhibition of Cell Migration in vivo and Granuloma Formation

Rosa¹

1979

Handbook of Experimental Pharmacology

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The avian microcrystal arthritis I. Simultaneous recording of nociception and temperature effect in the inflamed joint

Cited by 25 publications

References 12 publications

The avian microcrystal arthritis III. invasion and enzyme-release from leukocytes at the site of inflammation

The avian microcrystal arthritis III. invasion and enzyme-release from leukocytes at the site of inflammation

Projections of ankle joint afferents to the spinal cord and brainstem of the chicken (Gallus G. domesticus)

Inhibition of Cell Migration in vivo and Granuloma Formation

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