The Avocado (Persea americana Mill.) Leaf Extract on Streptozotocin-induced Pancreatic Cell Regeneration of White Rats (Rattus norvegicus)

Abstract

Objectibe The rate of pancreatic cell regeneration after avocado leaf extract intervention in a diabetic animal model induced by streptozotocin was investigated in this study. Method: Experimental study was conducted on 18 male white rats as subjects, which were divided into 6 groups, 3 animals of each. Those were G1 (Feed + Streptozotocin + 10% Sucrose + 100 mg/kg b.w. of extract + 0.5% NaCMC), G2 (Feed + Streptozotocin + 10% Sucrose + 150 mg/kg b.w. of extract + 0.5% NaCMC), G3 (Feed + Streptozotocin + 10% Sucrose + 200 mg/kg b.w. of extract + 0.5% NaCMC), G4 (Feed + Streptozotocin + 10% sucrose + 0.5% Na-CMC), G5 (Feed + Streptozotocin + 10% sucrose + Glibenclamid + 0.5% Na-CMC), G6 (Normal healthy animal + Feed). Results: The pancreatic cells damage in animal diabetic model, G1 = 1.67 (moderate cell damage); G2 = 1.00 (mild cell damage); G3 = 0.33 (no damage); G4 = 3.00 (severe cell damage); G5 = 0.33 (no damage); G6 = 0.33 (no damage). Conclusion: The dose of 200 mg/kg b.w. of avocado leaf extract contributed the most significant recovery of pancreatic cell of diabetic animal induced with streptozotocin, equivalent to glibenclamide.

The Effect of Giving Avocado Leaf and Seed Extract as Antidiabetes: A Systematic Literature Review

“…Increasing the dose of avocado extract seems to increase the regenerative effect on the pancreas. However, the most severe cell damage was seen in the group that received 0.5% Na-CMC vehicle (Rahman et al, 2021). This suggests that avocado ethanolic extract can enhance pancreatic cell regeneration and be a potential candidate as a regenerative agent in conditions of pancreatic cell damage.…”

“…Follow-up research conducted by Rahman et al (2020) showed that avocado leaf extract has the potential to increase kidney cell regeneration in male white rats with diabetes (Rahman et al, 2022). The results showed that the dose of avocado leaf extract affected the level of kidney damage, where the higher the dose of the extract given, the lower the level of kidney damage that occurred.…”