The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Generation 2 questionnaire data capture May-July 2020

Smith, Daniel; Northstone, Kate; Bowring, Claire; Wells, Nicholas; Crawford, Michael; Pearson, Rebecca; Thomas, Amy; Brooks-Pollock, Ellen; Lawlor, Debbie A.; Timpson, Nicholas J.

doi:10.12688/wellcomeopenres.16414.1

Cited by 5 publications

(4 citation statements)

References 42 publications

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“…To validate our findings for selected candidate metabolites associated with AAM and ANM, we tested the association of directly measured levels of these metabolites with the two traits in ALSPAC. The ALSPAC is a population-based birth cohort study, which enrolled 14,541 pregnant women resident in Avon, UK, with expected delivery dates between 1 April 1991 and 31 December 1992 [ 44 , 45 ]. Of the initial pregnancies, there was a total of 13,988 children who were alive at 1 year of age.…”

Section: Methodsmentioning

confidence: 99%

Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause

Yazdanpanah,

Gamache

et al. 2024

Genome Med

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Background The role of metabolism in the variation of age at menarche (AAM) and age at natural menopause (ANM) in the female population is not entirely known. We aimed to investigate the causal role of circulating metabolites in AAM and ANM using Mendelian randomization (MR). Methods We combined MR with genetic colocalization to investigate potential causal associations between 658 metabolites and AAM and between 684 metabolites and ANM. We extracted genetic instruments for our exposures from four genome-wide association studies (GWAS) on circulating metabolites and queried the effects of these variants on the outcomes in two large GWAS from the ReproGen consortium. Additionally, we assessed the mediating role of the body mass index (BMI) in these associations, identified metabolic pathways implicated in AAM and ANM, and sought validation for selected metabolites in the Avon Longitudinal Study of Parents and Children (ALSPAC). Results Our analysis identified 10 candidate metabolites for AAM, but none of them colocalized with AAM. For ANM, 76 metabolites were prioritized (FDR-adjusted MR P-value ≤ 0.05), with 17 colocalizing, primarily in the glycerophosphocholines class, including the omega-3 fatty acid and phosphatidylcholine (PC) categories. Pathway analyses and validation in ALSPAC mothers also highlighted the role of omega and polyunsaturated fatty acids levels in delaying age at menopause. Conclusions Our study suggests that metabolites from the glycerophosphocholine and fatty acid families play a causal role in the timing of both menarche and menopause. This underscores the significance of specific metabolic pathways in the biology of female reproductive longevity.

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Section: Methodsmentioning

confidence: 99%

Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause

Yazdanpanah,

Gamache

et al. 2024

Genome Med

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“…So far, ALSPAC has conducted four COVID-19 questionnaires using G0 and G1 data: the first between 9 th April and 15 th May 2020 8 , the second between 26 th May and 5 th July 2020 9 , the third -with a first home-based antibody test -between 3 rd and 20 th October 2020 10 , and the fourth between 17 th November 2020 and 19 th March 2021 11 . As part of the second questionnaire, parents of G2 children also completed a questionnaire for each of their children 12 .…”

Section: Introductionmentioning

confidence: 99%

The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Antibody testing results, April – June 2021

et al. 2022

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The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort which recruited pregnant women in 1990-1992 and has followed these women, their partners (Generation 0; G0) and their offspring (Generation 1; G1) ever since. The study reacted rapidly and repeatedly to the coronavirus disease 2019 (COVID-19) pandemic, deploying multiple online questionnaires and a previous home-based antibody test in October 2020. A second antibody test, in collaboration with ten other longitudinal population studies, was completed by 4,622 ALSPAC participants between April and June 2021. Of 4,241 participants with a valid spike protein antibody test result (8.2% were void), indicating antibody response to either COVID-19 vaccination or natural infection, 3,172 were positive (74.8%). Generational differences were substantial, with 2,463/2,555 G0 participants classified positive (96.4%) compared to 709/1,686 G1 participants (42.1%). Of 4,199 participants with a valid nucleocapsid antibody test result (9.2% were void), suggesting potential and recent natural infection, 493 were positive (11.7%); 248/2,526 G0 participants (9.8%) and 245/1,673 G1 participants (14.6%) tested positive, respectively. We also compare results for this round of testing to that undertaken in October 2020. Future work will combine these test results with additional sources of data to identify participants’ COVID-19 infection and vaccination status. These ALSPAC COVID-19 serology data are being complemented with linkage to health records and Public Health England pillar testing results as they become available, in addition to four previous questionnaire waves and a prior antibody test. Data have been released as an update to the previous COVID-19 datasets. These comprise: 1) a standard dataset containing all participant responses to all four previous questionnaires with key sociodemographic factors; and 2) individual participant-specific release files enabling bespoke research across all areas supported by the study. This data note describes the second ALSPAC antibody test and the data obtained from it.

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“…So far, ALSPAC has conducted three COVID-19 questionnaires using G0 and G1 data: the first between 9 th April to 15 th May 2020 7 , the second between 26 th May to 5 th July 2020 8 ; and the third, with an antibody test, between 3 rd and 20 th October 2020 9 . As part of the second questionnaire, parents of G2 children also completed a questionnaire for each of their children 10 .…”

Section: Introductionmentioning

confidence: 99%

The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture November 2020 – March 2021

Smith¹,

Bowring²,

Wells³

et al. 2021

Wellcome Open Res

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The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited pregnant women in 1990-1992 and has followed these women, their partners (Generation 0; G0) and their offspring (Generation 1; G1) ever since. The study has reacted rapidly and repeatedly to the coronavirus disease 2019 (COVID-19) pandemic, deploying online questionnaires throughout the pandemic. In November/December 2020, a fourth questionnaire was deployed asking about physical and mental health, lifestyle and behaviours, employment and finances. G0 participants were offered an online questionnaire between 17th November 2020 and 7th February 2021, while G1 participants were offered both online and paper questionnaires between 1st December 2020 and 19th March 2021. Of 15,844 invitations, 8,643 (55%) participants returned the questionnaire (3,101 original mothers [mean age 58.6 years], 1,172 original fathers/partners [mean age 61.5 years] and 4,370 offspring [mean age 28.4 years]). Of these 8,643 participants, 2,012 (23%) had not returned a previous COVID-19 questionnaire, while 3,575 (41%) had returned all three previous questionnaires. In this questionnaire, 300 participants (3.5%) reported a previous positive COVID-19 test, 110 (1.3%) had been told by a doctor they likely had COVID-19, and 759 (8.8%) suspected that they had had COVID-19. Based on self-reported symptoms, between October 2020 and February 2021 359 participants (4.2%) were predicted COVID-19 cases. COVID data is being complemented with linkage to health records and Public Health England pillar testing results as they become available. Data has been released as an update to the previous COVID-19 datasets. It comprises: 1) a standard dataset containing all participant responses to both questionnaires with key sociodemographic factors; and 2) as a composite release coordinating data from the existing resource, thus enabling bespoke research across all areas supported by the study. This data note describes the fourth questionnaire and the data obtained from it.

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The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Generation 2 questionnaire data capture May-July 2020

Cited by 5 publications

References 42 publications

Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause

Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause

The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Antibody testing results, April – June 2021

The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture November 2020 – March 2021

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