The Avon Longitudinal Study of Parents and Children (ALSPAC): an update on the enrolled sample of index children in 2019

Northstone, Kate; Lewcock, Melanie; Groom, Alix; Boyd, Andy; Macleod, John; Timpson, Nicholas J.; Wells, Nicholas

doi:10.12688/wellcomeopenres.15132.1

Cited by 524 publications

(476 citation statements)

References 3 publications

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“…We used data from the Avon Longitudinal Study of parents and Children (ALSPAC), a longitudinal cohort study that recruited pregnant women residing in the former area of Avon, UK with expected dates of delivery 1st April 1991 to 31st December 1992 (Boyd et al, 2013;Fraser et al, 2013). The initial cohort consisted of 14,062 live births, but has been increased to 14,901 children who were alive after one year with further recruitment (Northstone et al, 2019). Ethical approval was obtained from the ALSPAC Ethics and Law Committee and the Local Research Ethics Committees.…”

Section: Samplementioning

confidence: 99%

Polygenic Risk for Depression is Associated with the Severity and Rate of Change in Depressive Symptoms Across Adolescence

Kwong

Morris

Pearson

et al. 2020

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Adolescence marks a period where depression will commonly onset and previous research using twin studies has suggested that genetic influences play a role in how depression develops and changes across adolescence. Recent genome-wide association studies have also shown that common genetic variants − which can be combined into a polygenic risk score (PRS) − are also implicated in depression. However, the role of PRS in adolescent depression and changes in adolescent depression is not yet understood. We aimed to examine the association between a PRS for depressive symptoms and depressive symptoms across adolescence and young adulthood, and how polygenic risk is associated with changes in depressive symptoms using two methods: cross-sectional analysis and multilevel growth curve modelling to examine the rate of change over time. Using data from over 6000 participants of the Avon Longitudinal Study of Parents and Children (ALSPAC) we examined associations between genetic liability to depressive symptoms (PRS for depressive symptoms) and self-reported depressive symptoms (short mood and feelings questionnaire over 9 occasions from 10-24 years). We examined cross-sectional associations at each age and longitudinal trajectories of depressive symptoms in a repeated measures framework using growth curve analysis. The PRS was associated with depressive symptoms throughout adolescence and young adulthood in cross-sectional and growth curve analyses, though associations were stronger in the latter analyses. Growth curve analyses also provided additional insights, demonstrating that individuals with a higher PRS had steeper trajectories of depressive symptoms across adolescence with a greater increasing rate of change. These results show that common genetics variants as indexed by a PRS for depressive symptoms influence both the severity and rate of change in adolescent depressive symptoms. Longitudinal data that make use of repeated measures designs have the potential to provide greater insights into the factors that influence the onset and persistence of adolescent depression.

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Section: Samplementioning

confidence: 99%

Polygenic Risk for Depression is Associated with the Severity and Rate of Change in Depressive Symptoms Across Adolescence

Kwong

Morris

Pearson

et al. 2020

Preprint

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“…Pregnant women resident in a de ned region in the South West of England with an expected delivery date between April 1991 and December 1992 were recruited during pregnancy [32] [33]. The initial cohort consisted of 14,062 live births but has since increased to 14,901 children who were alive after one year with further recruitment [34]. Follow-up research has largely focused on the offspring, with data collected using a variety of methods including biological samples, clinic assessments, questionnaires, and interviews.…”

Section: Participantsmentioning

confidence: 99%

Peer victimisation during adolescence and its impact on wellbeing in adulthood: A prospective cohort study.

Armitage

Wang

Davis

et al. 2020

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Background: Peer victimisation is a common occurrence in schools and has well-established links with a range of psychiatric problems in adulthood. Significantly less is known however, about how victimisation influences positive aspects of mental health such as wellbeing. The purpose of this study was therefore to assess for the first time, whether peer victimisation in adolescence is associated with adult wellbeing. We aimed to understand whether individuals who avoid a diagnosis of depression after victimisation, maintain good wellbeing in later life, and therefore display resilience.Methods: Longitudinal data was taken from the Avon Longitudinal Study of Parents and Children, a prospective cohort study based in the UK. Peer victimisation was assessed at 13 years using a modified version of the bullying and friendship interview schedule, and wellbeing at age 23 using the Warwick-Edinburgh Mental Well-Being Scale. The presence or absence of depression was diagnosed using the Clinical Interview Schedule–Revised at 18 years. A series of logistic and linear regression analyses were used to explore relationships between peer victimisation, depression, and wellbeing, adjusting for potentially confounding individual and family factors. Results: Just over 15% of victims of frequent bullying had a diagnosis of depression at age 18. Victimisation also had a significant impact on wellbeing, with a one-point increase in frequent victimisation associated with a 2.71-point (SE=0.46, p<0.001) decrease in wellbeing scores aged 23. This finding was only partly attenuated when adjusting for depression, suggesting that the burden of victimisation extends beyond depression to impact wellbeing. Results therefore show that individuals who remain partially resilient by avoiding a diagnosis of depression after victimisation have significantly poorer wellbeing than their non-victimised counterparts.Conclusion: Overall, our study demonstrates for the first time that victimisation during adolescence is a significant risk factor for not only the onset of depression, but also poor wellbeing in adulthood. Such findings highlight the importance of investigating both dimensions of mental health to understand the true burden of victimisation and subsequent resilience. In addition to the need for interventions that reduce the likelihood of depression following adolescent victimisation, efforts should also be made to promote good wellbeing.

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“…The total sample size for analyses using any data collected after the age of seven is therefore 15,454 pregnancies, resulting in 15,589 foetuses. Of these, 14,901 were alive at 1 year of age 29 . The cohort has been followed intensively from birth through self-completed questionnaires and attending clinical assessment visits.…”

Section: Public Attitudes Towards Data Linkagementioning

confidence: 99%

Attitudes towards transactional data donation and linkage in a longitudinal population study: evidence from the Avon Longitudinal Study of Parents and Children

Skatova¹,

Shiells²,

Boyd³

2019

Wellcome Open Res

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Background: Commercial transaction records, such as data collected through banking and retail loyalty cards, present a novel opportunity for longitudinal population studies to capture data on participants’ real-world behaviours and interactions. However, little is known about participant attitudes towards donating transactional records for this purpose. This study aimed to: (i) explore the attitudes of longitudinal population study participants towards sharing their transactional records for health research and data linkage; and (ii) explore the safeguards that researchers should consider implementing when looking to request transactional data from participants for data linkage studies. Methods: Participants in the Avon Longitudinal Study of Parents and Children were invited to a series of three focus groups with semi-structured discussions designed to elicit opinions. Through asking participants to attend three focus groups we aimed to facilitate more in-depth discussions around the potentially complex topic of data donation and linkage. Thematic analysis was used to sort data into overarching themes addressing the research questions. Results: Participants (n= 20) expressed a variety of attitudes towards data linkage, which were associated with safeguards to address concerns. This data was sorted into three themes: information, trust, and control. We discuss the importance of explaining the purpose of data linkage, consent options, who the data is linked with and sensitivities associated with different parts of transactional data. We describe options for providing further information and controls that participants consider should be available when studies request access to transactional records. Conclusions: This study provides initial evidence on the attitudes and concerns of participants of a longitudinal cohort study towards transactional record linkage. The findings suggest a number of safeguards which researchers should consider when looking to recruit participants for similar studies, such as the importance of ensuring participants have access to appropriate information, control over their data, and trust in the organisation.

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The Avon Longitudinal Study of Parents and Children (ALSPAC): an update on the enrolled sample of index children in 2019

Cited by 524 publications

References 3 publications

Polygenic Risk for Depression is Associated with the Severity and Rate of Change in Depressive Symptoms Across Adolescence

Polygenic Risk for Depression is Associated with the Severity and Rate of Change in Depressive Symptoms Across Adolescence

Peer victimisation during adolescence and its impact on wellbeing in adulthood: A prospective cohort study.

Attitudes towards transactional data donation and linkage in a longitudinal population study: evidence from the Avon Longitudinal Study of Parents and Children

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