The BabyLux project - an optical neuro-monitor of cerebral oxygen metabolism and blood flow for neonatology

Weigel, Udo M.; Andresen, Björn F.; Chamizo, Victor; Contini, Davide; Carli, Agnese De; Donat, Roger; Durdurán, Turgut; Erdmann, Rainer; Fumagalli, Monica; Giovannella, Martina; Greisen, Gorm; Hyttel-Sørensen, Simon; König, Niels; Lauritsen, Kristian; Pagliazzi, Marco; Pifferi, Antonio; Rehberger, Matthias; Rocchetti, Ignacio; Röhlicke, Tino; Spinelli, Lorenzo; Wahl, Michael; Torricelli, Alessandro

doi:10.1364/cancer.2016.jm3a.30

Cited by 5 publications

(4 citation statements)

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“…The BabyLux project aimed to develop a device to continuously monitor cerebral oxygenation and blood flowand hence monitor oxygen metabolismby near-infrared spectroscopy (NIRS), integrating time-resolved reflectance spectroscopy (TRS) (2) with diffuse correlation spectroscopy (DCS) (3) in a single device operating continuously under clinical conditions, providing robust measurements with a relatively high temporal resolution that would be suitable for use in neonates (4). In newborns, the distance from skin to brain is less than 5 mm, so optical methods could be particularly useful in this population (5).…”

Section: Introductionmentioning

confidence: 99%

Cerebral oxygenation and blood flow in normal term infants at rest measured by a hybrid near-infrared device (BabyLux)

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Cerebral oxygenation and blood flow in normal term infants at rest measured by a hybrid near-infrared device (BabyLux)

et al. 2019

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“…By moving the DCS operation from continuous wave (CW) to the time domain, we exploit the many advantages of time-resolved reflectance spectroscopy (TRS), where a train of ultra-fast laser pulses is used to measure the TOF through the tissue and their distribution, the so-called temporal point-spread function (TPSF) [25–27]. This enables us, for the first time to our knowledge, to employ the time-gating strategies [28–30] used in TRS for DCS blood flow measurements and to realize improvements that are not possible when the two techniques are performed independently [31]. …”

Section: Introductionmentioning

confidence: 99%

Time-domain diffuse correlation spectroscopy

Sutin

Zimmerman

Tyulmankov

et al. 2016

Optica

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Physiological monitoring of oxygen delivery to the brain has great significance for improving the management of patients at risk for brain injury. Diffuse correlation spectroscopy (DCS) is a rapidly growing optical technology able to non-invasively assess the blood flow index (BFi) at the bedside. The current limitations of DCS are the contamination introduced by extracerebral tissue and the need to know the tissue’s optical properties to correctly quantify the BFi. To overcome these limitations, we have developed a new technology for time-resolved diffuse correlation spectroscopy. By operating DCS in the time domain (TD-DCS), we are able to simultaneously acquire the temporal point-spread function to quantify tissue optical properties and the autocorrelation function to quantify the BFi. More importantly, by applying time-gated strategies to the DCS autocorrelation functions, we are able to differentiate between short and long photon paths through the tissue and determine the BFi for different depths. Here, we present the novel device and we report the first experiments in tissue-like phantoms and in rodents. The TD-DCS method opens many possibilities for improved non-invasive monitoring of oxygen delivery in humans.

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“…With respect to current combined NIRS and DCS systems, using only DCS there are advantages in reducing cost, size, and complexity of the device. For instance, typical NIRS-DCS systems consist of a DCS component and either an FDNIRS 23 or a time-resolved spectroscopy (TRS) component 36 . The NIRS and DCS components do not share either sources or detectors, which leads to a more complex system architecture and increased costs and size of the combined system with respect to a stand-alone system.…”

Section: Discussionmentioning

confidence: 99%

Development and characterization of a multidistance and multiwavelength diffuse correlation spectroscopy system

Tamborini

Zimmermann

et al. 2017

Neurophoton

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, "Development and characterization of a multidistance and multiwavelength diffuse correlation spectroscopy system," Neurophoton. 5(1), 011015 (2017), doi: 10.1117/1.NPh.5.1.011015. Abstract. This paper presents a multidistance and multiwavelength diffuse correlation spectroscopy (DCS) approach and its implementation to simultaneously measure the optical proprieties of deep tissue as well as the blood flow. The system consists of three long coherence length lasers at different wavelengths in the near-infrared, eight single-photon detectors, and a correlator board. With this approach, we collect both light intensity and DCS data at multiple distances and multiple wavelengths, which provide unique information to fit for all the parameters of interest: scattering, blood flow, and hemoglobin concentration. We present the characterization of the system and its validation with phantom measurements.

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The BabyLux project - an optical neuro-monitor of cerebral oxygen metabolism and blood flow for neonatology

Abstract: BabyLux project is driven by the end-users working with academia and industry to develop a hybrid near-infrared diffuse correlation spectroscopy (DCS)/ time resolved spectroscopy (TRS) system to address the challenge of a user-friendly, medical grade device for neonatology

Cited by 5 publications

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Cerebral oxygenation and blood flow in normal term infants at rest measured by a hybrid near-infrared device (BabyLux)

Cerebral oxygenation and blood flow in normal term infants at rest measured by a hybrid near-infrared device (BabyLux)

Time-domain diffuse correlation spectroscopy

Development and characterization of a multidistance and multiwavelength diffuse correlation spectroscopy system

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