The BACHD rat model of Huntington disease shows slowed learning in a Go/No-Go-like test of visual discrimination

Clemensson, Erik Karl Håkan; Novati, Arianna; Clemensson, Laura Emily; Rieß, Olaf; Nguyen, Huu Phuc

doi:10.1016/j.bbr.2018.10.036

Cited by 3 publications

(2 citation statements)

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“…One of the main executive function deficits is impaired inhibitory control, which can be detected in specific behavioral tests in HD patients [238,239] . It was also shown in HD fragment and knock-in mouse models [240,241] and in transgenic rats [242][243][244][245] . Rat models, in general, may be advantageous over mouse models in the applied paradigms and have been largely used in preclinical research on impulsive control [246] .…”

Section: Behavioral Phenotypes In Genetic Rat Models Of Parkinson's D...mentioning

confidence: 99%

Rat models of major neurodegenerative disorders

Novati¹,

Singer-Mikosch²,

Yu-Taeger³

et al. 2022

Ageing Neur Dis

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No single animal model can recapitulate all the features of a particular human disease on its own. Historically, rats have been used to study neurobiology and underlying functional networks. Likewise, rat models have been created to study neurodegenerative mechanisms and therapeutic interventions. In the last decades, a shift towards the use of mice has been observed in many research fields, not least because of the comparatively easier genetic manipulation of mice. However, with the full sequence of the rat genome being available, advances in genetic manipulation of the rat, and advanced test regimens and biomarkers at hand, the rat presents itself once more as a valuable model organism for studying neurodegenerative disorders. This review provides an overview of currently available, well-characterized rat models of Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, as well as their advantages for studying neurodegenerative disorders and evaluating therapeutic interventions.

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Section: Behavioral Phenotypes In Genetic Rat Models Of Parkinson's D...mentioning

confidence: 99%

Rat models of major neurodegenerative disorders

Novati¹,

Singer-Mikosch²,

Yu-Taeger³

et al. 2022

Ageing Neur Dis

View full text Add to dashboard Cite

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“…Mielcarek et al [2014a], observaron fibrosis e incremento de núcleos apoptóticos en cardiomiocitos de ratones pre-sintomáticos. En el modelo denominado BACHD (ratones que portan una construcción transgénica, bacterial artificial chromosome (BAC),) que cubre todo el gen humano de la mHtt [Clemensson et al, 2019]), se detectaron diferencias estructurales y funcionales en animales pre-sintomáticos desde los 3 meses de edad hasta su vejez (15 meses de edad). Además, los ratones jóvenes mostraron una sobre-regulación de la respuesta inmune pro-inflamatoria que contribuye a dichos cambios [Schroeder et al, 2016].…”

Section: Enfermedad De Huntington: ¿Desorden Neurocardíaco?unclassified

Inducción del factor de transcripción Nrf2 en dos contextos patológicos: Enfermedad de Huntington asociada a la edad e isquemia-reperfusión cardíaca

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AMPK: Cinasa activada por adenosina monofosfato (protein kinase AMP-activated) ANOVA: Análisis de varianza de una vía Atg: Proteinas relacionadas a autofagia (autophagy-related protein) ADN: Ácido desoxirribonucleico ADP: Adenosín difosfato ARE: Elemento de respuesta antioxidante (antioxidant response element) ATP: Adenosín trifosfato Buffer RIPA: Buffer de ensayo de radioinmunoprecipitación (RadioImmunoPrecipitation Assay

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