The bacterial load of Ureaplasma parvum in amniotic fluid is correlated with an increased intrauterine inflammatory response

Kasper, David C.; Mechtler, Thomas P.; Reischer, Georg H.; Witt, Armin; Langgartner, Michaela; Pollak, Arnold; Herkner, Kurt; Berger, Angelika

doi:10.1016/j.diagmicrobio.2009.12.023

Cited by 87 publications

(70 citation statements)

References 29 publications

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“…Hence, we postulate that merely the fact of vaginal colonisation with U. urealyticum and/or M. hominis per se is a poor predictor of an abnormal pregnancy outcome, but high density vaginal mycoplasma colonisation, and its associated microflora abnormalities, should be considered a risk factor for chorionamnionitis and preterm birth. Other studies have confirmed that only a high load of ureaplasmas is related to adverse pregnancy outcomes (Abele-Horn et al, 2000;Kasper et al, 2010).…”

Section: Discussionmentioning

confidence: 94%

Composition of Vaginal Microflora in Relation to Vaginal pH and Wet Mount Diagnostic Tests in the First Trimester of Pregnancy

Žodžika

Rezeberga

Donders

et al. 2014

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Section: Discussionmentioning

confidence: 94%

Composition of Vaginal Microflora in Relation to Vaginal pH and Wet Mount Diagnostic Tests in the First Trimester of Pregnancy

Žodžika

Rezeberga

Donders

et al. 2014

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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“…In contrast, quantitative real-time PCR (qPCR) using fluorescence dyes or probes facilitate the quantification of amplified viral, bacterial, and parasitic products. As it was previously discussed, in some obstetric complications the amount of bacteria is more important than the mere presence of it [16].…”

Section: Quantitative-pcr (Qpcr)mentioning

confidence: 88%

“…Kasper et al [16] found that the increased amount of U. parvum was significantly linked to histological chorioamnionitis, PROM together with preterm labor, early-onset sepsis, and bronchopulmonary dysplasia. Furthermore, no significant difference between the bacterial load of U. urealyticum and neonatal outcome was observed [16]. The importance of bacterial load was found by Abele-Horn et al [17].…”

Section: Ureaplasma Sppmentioning

confidence: 99%

Urogenital Mycoplasmosis and Pregnancy

Põder¹,

Haldre²

2016

J Antimicrob Agents

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Urogenital mycoplasmas Ureaplasma urealyticum, Ureaplasma parvum and Mycoplasma hominis have long been considered commensals of human urogenital microflora. Several studies have recently clarified whether these bacteria could cause or be associated with various obstetric complications. Epidemiologic studies have found high prevalence of Ureaplasma spp. and M. hominis among otherwise healthy population. On the other hand, U. urealyticum, U. parvum and M. hominis have increasingly been linked to adverse pregnancy outcomes such as spontaneous pre-term labor, pre-term premature rupture of fetal membranes, miscarriage, stillbirth and low birth weight. However, no convincing causal relationship has been shown. Studies have shown that antibiotics resistance is on the rise and differs considerably by regions. Screening of asymptomatic patients for M. hominis, U. urealyticum and U. parvum is currently still not indicated.

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“…The species and serotypes selected reflected the predominant species and serotypes in the clinical strains from placentas and amniotic fluid of preterm births as reported by others (29)(30)(31)(32) and observed by us (unpublished data: Weisman LE, et al E-PAS 2009:3877.412). Ureaplasma species was identified utilizing PCR as described previously (33).…”

Section: Organismsmentioning

confidence: 89%

Appropriate antibiotic therapy improves Ureaplasma sepsis outcome in the neonatal mouse

2012

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Background: Ureaplasma causes sepsis in human neonates. although erythromycin has been the standard treatment, it is not always effective. No published reports have evaluated Ureaplasma sepsis in a neonatal model. We hypothesized that appropriate antibiotic treatment improves Ureaplasma sepsis in a neonatal mouse model. Methods: Two aTcc strains and two clinical strains of Ureaplasma were evaluated in vitro for antibiotic minimum inhibitory concentration (MIc). In addition, FVB albino mice pups infected with Ureaplasma were randomly assigned to saline, erythromycin, or azithromycin therapy and survival, quantitative blood culture, and growth were evaluated. results: MIcs ranged from 0.125 to 62.5 µg/ml and 0.25 to 1.0 µg/ml for erythromycin and azithromycin, respectively. The infecting strain and antibiotic selected for treatment appeared to affect survival and bacteremia, but only the infecting strain affected growth. azithromycin improved survival and bacteremia against each strain, whereas erythromycin was effective against only one of four strains. conclusion: We have established a neonatal model of Ureaplasma sepsis and observed that treatment outcome is related to infecting strain and antibiotic treatment. We speculate that appropriate antibiotic selection and dosing are required for effective treatment of Ureaplasma sepsis in neonates, and this model could be used to further evaluate these relationships.

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The bacterial load of Ureaplasma parvum in amniotic fluid is correlated with an increased intrauterine inflammatory response

Cited by 87 publications

References 29 publications

Composition of Vaginal Microflora in Relation to Vaginal pH and Wet Mount Diagnostic Tests in the First Trimester of Pregnancy

Composition of Vaginal Microflora in Relation to Vaginal pH and Wet Mount Diagnostic Tests in the First Trimester of Pregnancy

Urogenital Mycoplasmosis and Pregnancy

Appropriate antibiotic therapy improves Ureaplasma sepsis outcome in the neonatal mouse

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