The balance between the pro-inflammatory effect of plasma noradrenaline and the anti-inflammatory effect of neuronal noradrenaline determines the peripheral effects of noradrenaline

Crotty, T.P.

doi:10.1016/j.mehy.2014.08.026

Cited by 3 publications

(4 citation statements)

References 104 publications

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“…The CNS and the immune system cooperate in the assessment of stress and defense against it and in maintaining or restoring the cellular homeostasis [45,46]. The sympathetic modulation of immunity is key in the cellular defenses to cope infection and diseases, including autoimmune diseases [45].…”

Section: Interactions Of Catecholamines With Immune Systemmentioning

confidence: 99%

“…As previously noted, the duality of physiological role of CATs is reported: The antiinflammatory action and cytotoxic proinflammatory action [18]. The anti-inflammatory effect is the result of CAT action on β 2 -ARs and includes both inhibition of T-helper1 proinflammatory cytokines, such as interleukin 12 (IL-12), TNF-α, interferon-γ (IFN-γ), and induction of T-helper 2, IL-10, and transforming growth factor beta (TGF-β) [46,47].…”

Section: Interactions Of Catecholamines With Immune Systemmentioning

confidence: 99%

“…The proinflammatory immune response of the CATs resulting in activation of β-ARs on human lymphocytes involves stimulation of the proinflammatory cytokine IL-12 release followed by an increase of IFN-γ. Other proinflammatory effects may result from activation of α 1 -ARs on J U S T A C C E P T E D macrophages or induction of cyclooxygenase-2 (COX-2) [46,48]. Moreover, autoxidation of CATs is accompanied by production of superoxide anion radical (O 2• ‾) followed by formation of other ROS/RNS, toxic to cells agents when they are formed in excess [49][50][51].…”

Section: Interactions Of Catecholamines With Immune Systemmentioning

confidence: 99%

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Physical exercise and catecholamines response: benefits and health risk: possible mechanisms

Kruk

Kotarska

Aboul‐Enein

2020

Free Radical Research

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Beneficial effect of regular moderate physical exercise (PE) and negative effect of severe exercise and/or overtraining as an activator of the sympathetic nervous system (SNS) have been shown in numerous aspects of human health, including reduced risk of cardiovascular disease, neurological disease, depression, and some types of cancer. Moderate-to-vigorous PE stimulates the SNS activation, releasing catecholamines (CATs) adrenaline, noradrenaline, dopamine that play an important regulatory and modulatory actions by affecting metabolic processes and the immune system. Summary of the dispersed literature in this area and explanation of the biological mechanisms operating between PE-CATs and the immune system would lead to a better understanding of the beneficial and negative effects of PE on health. This overview aimed to: demonstrate representative literature findings on the exercise released CATs levels, major functions performed by these hormones, their interactions with immune system and their effects on carbohydrate and lipid metabolism. Also, mechanisms of cytotoxic free radicals and reactive oxygen species generation during CATs oxidation, and molecular mechanisms of CATs response to exercise are discussed to demonstrate positive and negative on human health effects. Owing to the large body of the subject literature, we present a representative cross-section of the published studies in this area.The results show a significant role of CATs in carbohydrate and lipid metabolism, immunity and as generators of reactive oxygen species, depending on PE intensity and duration. Further investigation of the PE-CATs relationship should validate CATs levels to optimize safe intensity and duration of exercise and individualize their prescription, considering CATs to be applied as markers for a dose of exercise. Also, a better understanding of the biological mechanisms is also needed.

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Section: Interactions Of Catecholamines With Immune Systemmentioning

confidence: 99%

Section: Interactions Of Catecholamines With Immune Systemmentioning

confidence: 99%

Section: Interactions Of Catecholamines With Immune Systemmentioning

confidence: 99%

See 1 more Smart Citation

Physical exercise and catecholamines response: benefits and health risk: possible mechanisms

Kruk

Kotarska

Aboul‐Enein

2020

Free Radical Research

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“…Other cardiac disorders found in Group II had an inflammatory mechanism of development. An increased sympathetic tone captures elevated pro-inflammatory activity [16][17][18] .…”

Section: Discussionmentioning

confidence: 99%

"Dysautonomia Involvement in Maternal Cardiac Arrhythmia"

LAKHNO¹,

KNIAZKOVA²,

AKHNO³

et al. 2022

Arch Balk Med Union

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Implication de la dysautonomie dans l'arythmie cardiaque maternelleIntroduction. Le rôle du déséquilibre autonome dans l'arythmie cardiaque maternelle (AC) est encore discutable. L'objectif de l'étude était d'évaluer la relation entre le tonus autonome maternel et l'AC chez les femmes enceintes. Résultats. L'enquête de la DEB a révélé une hétérogénéité dans les groupes d'étude. L'activité sympathique accrue a été déterminée chez les femmes atteintes d'AC et de cardiopathie structurelle. Les femmes enceintes atteintes d'AC idiopathique ont démontré un schéma parasympathique de régulation nerveuse autonome. Les relations révélées entre DEB et la régulation sympathique ou parasympathique démontrent une augmentation du tonus sympathique chez les patients atteints de cardiopathie structurelle. Chez les femmes atteintes d'AC idiopathique, la régulation parasympathique a joué un rôle important dans le scénario de l'ectopie cardiaque.

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Ageing is a process where the growth effect of neuronal noradrenaline changes progressively in favour of the flow mediated, neurodegenerative and inflammatory effect of plasma noradrenaline

Crotty

2016

Medical Hypotheses

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The balance between the pro-inflammatory effect of plasma noradrenaline and the anti-inflammatory effect of neuronal noradrenaline determines the peripheral effects of noradrenaline

Cited by 3 publications

References 104 publications

Physical exercise and catecholamines response: benefits and health risk: possible mechanisms

Physical exercise and catecholamines response: benefits and health risk: possible mechanisms

"Dysautonomia Involvement in Maternal Cardiac Arrhythmia"

Ageing is a process where the growth effect of neuronal noradrenaline changes progressively in favour of the flow mediated, neurodegenerative and inflammatory effect of plasma noradrenaline

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