BackgroundMedical-grade oxygen is an essential component of modern healthcare, with a wide variety of applications ranging from supplemental use in surgery and trauma patients to the primary medication in oxygen therapy. This is the most effective treatment for any respiratory illness. Despite the importance of medicinal oxygen for public health and its demand as a life-saving drug, research on the subject is limited, with the majority of studies conducted following the outbreak of the COVID-19 pandemic. Due to the lack of empirical studies, we aimed to compile the recent research efforts with the current state of the field to guide the new researchers around the topic.MethodsWe have performed a systematic review targeting the medical oxygen ecosystem, following the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P). For the study, we have limited our scope to healthcare facilities and domiciliary applications of medical oxygen and considered the articles published in the last thirty years.ResultsOur systematic search resulted in forty-three scientific articles, with three more miscellaneous articles appended for painting a complete picture. Based on the selected articles, the complete oxygen ecosystem was categorized into five main fields.ConclusionWe have presented an in-depth analysis of the research works found through the systematic search, and a brief discussion on the current scenario of the subject referencing these studies. We hope to benefit researchers approaching this area through this study, and guide them around the topic.