Introduction: Given the intensive development of the labor market, the study of self-realization strategies is an urgent task. In this study, the importance of mental well-being on the path of professional development is also an urgent problem for scientific knowledge. The purpose of this study is to identify key self-realization strategies, define their role in professional development, and assess their impact on mental well-being. Methods: The study is a mixed-methods research: it involves the processing of both qualitative (scientific literature) and quantitative materials (survey data). The participants of this study are 112 people who were included on the basis of pre-established criteria. The main research tool was a questionnaire consisting of open and closed questions. Most of the questions are based on a Likert scale (from 1 to 5). Results: The results determined that self-realization, which affects the quality of life and the level of satisfaction with one's professionalism. Self-realization strategies optimize and develop various individual capabilities. They involve individual participation in professional development programs, leadership development, coaching, etc. Coaching provides emotional support and helps individuals overcome challenges. The results demonstrate the role of coach support in improving mental health and maintaining confidence. Conclusions: In the research the positive impact of coaching on increasing motivation, improving well-being and generally improving work efficiency was noted. In addition, the acquired knowledge helped the participants of the experiment to achieve the main goals in terms of professional development.