The bare bones appearance of hyperparathyroidism: Distinguishing subperiosteal bone resorption from periosteal reaction

Rothschild, Bruce M.

doi:10.1002/oa.3063

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…No bone deformations indicative of healed fractures were present. Absence of subperiosteal bone resorption or large resorption cavities rules out hyperparathyroidism, which would also not be associated with massive new bone deposition 22,23 . The documentation collected from gross anatomy, histology, and X-ray computed microtomography suggests a fast-growing bone mass (e.g., huge lacunae and higher vascularization) and abnormal new bone deposition as a result of increased cell proliferation, characteristic for neoplasia 21,22 .…”

Section: Discussionmentioning

confidence: 99%

An insight into cancer palaeobiology: Does the Mesozoic neoplasm support Tissue Organization Field Theory of tumorigenesis?

Surmik

Słowiak-Morkovina

Szczygielski

et al. 2022

Preprint

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Neoplasms are common across the animal kingdom and seem to be a feature plesiomorphic for metazoans, related with an increase in somatic complexity. The fossil record of cancer complements our knowledge of the origin of neoplasms and vulnerability of various vertebrate taxa. Here, we document the rst undoubted record of primary malignant bone tumour in a Mesozoic non-amniote. The diagnosed osteosarcoma developed in the vertebral intercentrum of a temnospondyl amphibian, Metoposaurus krasiejowensis from the Krasiejów locality, southern Poland. A wide array of data collected from gross anatomy and microstructure of the affected intercentrum reveals the tumour growth dynamics and pathophysiological aspects of the neoplasm formation on the histological level. The neoplastic bone mimics on the structural level the fast growing brolamellar bone, but on the histological level develops through a novel ossi cation type. The physiological process of bone remodelling inside the endochondral domain continued uninterrupted across the pathology of the periosteal part. Based on the results, we discuss our case study's consistence with the Tissue Organization Field Theory of tumorigenesis, which locates the causes of neoplastic transformations in disorders of tissue architecture.

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Section: Discussionmentioning

confidence: 99%

An insight into cancer palaeobiology: Does the Mesozoic neoplasm support Tissue Organization Field Theory of tumorigenesis?

Surmik

Słowiak-Morkovina

Szczygielski

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…No bone deformations indicative of healed fractures were present. Absence of subperiosteal bone resorption or large resorption cavities rules out hyperparathyroidism, which would also not be associated with massive new bone deposition [ 22 , 23 ]. The documentation collected from gross anatomy, histology, and X-ray computed micro-tomography suggests a fast-growing bone mass (e.g., huge lacunae and higher vascularization) and abnormal new bone deposition as a result of increased cell proliferation, characteristic for neoplasia [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

An insight into cancer palaeobiology: does the Mesozoic neoplasm support tissue organization field theory of tumorigenesis?

et al. 2022

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Background Neoplasms are common across the animal kingdom and seem to be a feature plesiomorphic for metazoans, related with an increase in somatic complexity. The fossil record of cancer complements our knowledge of the origin of neoplasms and vulnerability of various vertebrate taxa. Here, we document the first undoubted record of primary malignant bone tumour in a Mesozoic non-amniote. The diagnosed osteosarcoma developed in the vertebral intercentrum of a temnospondyl amphibian, Metoposaurus krasiejowensis from the Krasiejów locality, southern Poland. Results A wide array of data collected from gross anatomy, histology, and microstructure of the affected intercentrum reveals the tumour growth dynamics and pathophysiological aspects of the neoplasm formation on the histological level. The pathological process almost exclusively pertains to the periosteal part of the bone composed from a highly vascularised tissue with lamellar matrix. The unorganised arrangement of osteocyte lacunae observed in the tissue is characteristic for bone tissue types connected with static osteogenesis, and not for lamellar bone. The neoplastic bone mimics on the structural level the fast growing fibrolamellar bone, but on the histological level develops through a novel ossification type. The physiological process of bone remodelling inside the endochondral domain continued uninterrupted across the pathology of the periosteal part. Conclusions Based on the results, we discuss our case study’s consistence with the Tissue Organization Field Theory of tumorigenesis, which locates the causes of neoplastic transformations in disorders of tissue architecture.

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Bone abnormalities in the middle Anisian marine sauropsids from Winterswijk

Surmik

Szczygielski

Słowiak-Morkovina

et al. 2022

Journal of Morphology

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While the occurrence of skeletal pathologies in Middle Triassic marine reptiles has been poorly documented until now, massive accumulations of bone remains from the Germanic Basin provide the opportunities for documentation. Herein, we describe skeletal abnormalities in the Middle Triassic bone material from the Vossenveld Formation of Winterswijk, the Netherlands. The aim of the study is to distinguish in the studied bones pathologies resulting from malady or trauma and taphonomic alterations. Furthermore, an attempt was made to assess on how the pathologies also represent paleoecological data. Our survey led to the identification of one broken and healed bone, one case of abnormal coossification, and one case of posttraumatic fibro-osseous dysplasia. While the latter two pathologies give little insight into the ecology and function of the affected animals, the fractured dentary is attributed to Nothosaurus marchicus, a common sauropterygian macropredator. It proves that the individual survived long enough to heal, despite the injury hampering its hunting potential. One abnormally shaped humerus is interpreted as postmortem taphonomic deformation, emphasizing the necessity of utilization of detailed diagnostics to distinguish actual paleopathologies from nonbiological distortion.

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The bare bones appearance of hyperparathyroidism: Distinguishing subperiosteal bone resorption from periosteal reaction

Cited by 4 publications

References 33 publications

An insight into cancer palaeobiology: Does the Mesozoic neoplasm support Tissue Organization Field Theory of tumorigenesis?

An insight into cancer palaeobiology: Does the Mesozoic neoplasm support Tissue Organization Field Theory of tumorigenesis?

An insight into cancer palaeobiology: does the Mesozoic neoplasm support tissue organization field theory of tumorigenesis?

Bone abnormalities in the middle Anisian marine sauropsids from Winterswijk

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