The Basal Ganglia in Action

Yin, Henry H.

doi:10.1177/1073858416654115

Cited by 78 publications

(56 citation statements)

References 59 publications

(112 reference statements)

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“…Our findings suggest that VTA GABAergic neurons not only represent head angles, but also generate desired 10 angles during continuous behavior. This is possible if their output, acting as reference signals, quantitatively dictate the sensory states to be reached by lower level systems (Yin, 2017).…”

Section: Discussionmentioning

confidence: 99%

Precise Coordination of 3-dimensional Rotational Kinematics by Ventral Tegmental Area GABAergic Neurons

Hughes

Watson

Petter

et al. 2019

Preprint

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The Ventral Tegmental Area (VTA) is a midbrain region implicated in a variety of motivated behaviors. However, the function of VTA GABAergic (Vgat+) neurons remains poorly understood. Here, using 3D motion capture, in vivo electrophysiology and calcium imaging, and optogenetics, we demonstrate a novel function of VTA Vgat+ neurons. We found 5 three distinct populations of neurons, each representing head angle about a principal axis of rotation: pitch, roll, and yaw. For each axis, opponent cell groups were found that increase firing when the head moves in one direction, and decrease firing in the opposite direction. Selective excitation and inhibition of VTA Vgat+ neurons generate opposite rotational movements. The relationship between these neurons and head angle is degraded only at the time of reward 10 consumption, at which point all head-angle related neuronal subpopulations show indistinguishable reward-related responses. Thus, VTA Vgat+ neurons serve a critical role in the control of rotational kinematics while pursuing a moving target. This general-purpose steering function can guide animals toward desired spatial targets in any motivated behavior. 15 20 25 30 3

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Section: Discussionmentioning

confidence: 99%

Precise Coordination of 3-dimensional Rotational Kinematics by Ventral Tegmental Area GABAergic Neurons

Hughes

Watson

Petter

et al. 2019

Preprint

Self Cite

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“…Some conceptual models of nigrostriatal phasic signaling in motor performance suggest that dopaminergic signaling is involved in feedback control of motor performance by matching sensory feedback about motor performance to internal representations of desired actions. 46,47,48 These concepts bear a general family resemblance to temporal difference models of reinforcement learning in that they incorporate updating internal representations of action outcomes. In an ingenious experiment, Gadagkar et al evaluated the role of phasic nigrostriatal signaling in fine coordination of a complex motor act, zebra finch singing.…”

Section: Phasic Striatal Dopamine Signalingmentioning

confidence: 99%

The missing, the short, and the long: Levodopa responses and dopamine actions

Albin

Leventhal

2017

Annals of Neurology

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We attempt to correlate the clinical pharmacology of dopamine replacement therapy (DRT) in Parkinson Disease with known features of striatal dopamine actions. Despite its obvious impact, DRT does not normalize motor function, likely due to disrupted phasic dopaminergic signaling. The DRT Short Duration Response is likely a permissive-paracrine effect, possibly resulting from dopaminergic support of corticostriate synaptic plasticity. The DRT Long Duration Response may result from mimicry of tonic dopamine signaling regulation of movement vigor. Our understanding of dopamine actions does not explain important aspects of DRT clinical pharmacology. Reducing these knowledge gaps provides opportunities to improve understanding of dopamine actions and symptomatic treatment of Parkinson disease.

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“…These non-striatal projections mainly arise from the VTA (Gasbarri et al, 1997), although the SNc does give rise to a small hippocampal projection (Scatton et al, 1980). Midbrain dopaminergic neurons have crucial roles in movement initiation and control, signaling reward and salience of environmental events, and several other brain functions (Schultz, 2007; Wickens et al, 2007; Palmiter, 2008; Yin, 2016). A second, lesser known source of dopaminergic neurons is the ventral periaqueductal gray (PAG)/dorsal raphe nucleus (DRN) border region (Dougalis et al, 2012).…”

Section: Dopamine Receptorsmentioning

confidence: 99%

Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction?

Johnson

Lovinger

2016

Front. Cell. Neurosci.

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Drug abuse and addiction cause widespread social and public health problems, and the neurobiology underlying drug actions and drug use and abuse is an area of intensive research. Drugs of abuse alter synaptic transmission, and these actions contribute to acute intoxication as well as the chronic effects of abused substances. Transmission at most mammalian synapses involves neurotransmitter activation of two receptor subtypes, ligand-gated ion channels that mediate fast synaptic responses and G protein-coupled receptors (GPCRs) that have slower neuromodulatory actions. The GPCRs represent a large proportion of neurotransmitter receptors involved in almost all facets of nervous system function. In addition, these receptors are targets for many pharmacotherapeutic agents. Drugs of abuse directly or indirectly affect neuromodulation mediated by GPCRs, with important consequences for intoxication, drug taking and responses to prolonged drug exposure, withdrawal and addiction. Among the GPCRs are several subtypes involved in presynaptic inhibition, most of which are coupled to the Gi/o class of G protein. There is increasing evidence that these presynaptic Gi/o-coupled GPCRs have important roles in the actions of drugs of abuse, as well as behaviors related to these drugs. This topic will be reviewed, with particular emphasis on receptors for three neurotransmitters, Dopamine (DA; D1- and D2-like receptors), Endocannabinoids (eCBs; CB1 receptors) and glutamate (group II metabotropic glutamate (mGlu) receptors). The focus is on recent evidence from laboratory animal models (and some evidence in humans) implicating these receptors in the acute and chronic effects of numerous abused drugs, as well as in the control of drug seeking and taking. The ability of drugs targeting these receptors to modify drug seeking behavior has raised the possibility of using compounds targeting these receptors for addiction pharmacotherapy. This topic is also discussed, with emphasis on development of mGlu2 positive allosteric modulators (PAMs).

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The Basal Ganglia in Action

Cited by 78 publications

References 59 publications

Precise Coordination of 3-dimensional Rotational Kinematics by Ventral Tegmental Area GABAergic Neurons

Precise Coordination of 3-dimensional Rotational Kinematics by Ventral Tegmental Area GABAergic Neurons

The missing, the short, and the long: Levodopa responses and dopamine actions

Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction?

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