The bayesian approach to the evaluation of risk factors in acute and recurrent acute otitis media

Sipilä, Markku; Karma, Pekka; Pukander, J.; Timonen, Markku; Kataja, Matti

doi:10.3109/00016488809107375

Cited by 78 publications

(44 citation statements)

References 13 publications

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“…22 Socioeconomic deprivation has been described as a risk factor for acute and recurrent OM associated in numerous international studies. [32][33][34] Determining the basis for disparate prevalence and treatment of OM in children from lower socioeconomic strata is essential to identify barriers that prohibit these children from accessing timely and appropriate evaluation and therapy for OM.…”

Section: Discussionmentioning

confidence: 99%

Racial/Ethnic and socioeconomic disparities in the prevalence and treatment of otitis media in children in the United States

Boss

2010

The Laryngoscope

111

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Racial/ethnic and socioeconomic disparities exist for the prevalence and treatment of children with OM. Socioeconomic deprivation increases the risk of OM in children. Despite the frequency of tympanostomy tube insertion in children in the United States, few studies have addressed inequalities in access or utilization of surgical therapy. Given the changing healthcare climate and the social and economic impact of OM in children, further investigation of racial/ethnic and socioeconomic disparities targeting access to surgical treatment of OM should take precedence in health services research.

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Section: Discussionmentioning

confidence: 99%

Racial/Ethnic and socioeconomic disparities in the prevalence and treatment of otitis media in children in the United States

Boss

2010

The Laryngoscope

111

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“…1 These conditions are often treated with tympanostomy tubes to ventilate the middle ear; this is the most common surgical procedure performed in children in an ambulatory setting. 8 Epidemiologic studies 2,9,10 have shown that a family history of these conditions increase a child's personal risk for COME/ ROM, and twin studies 11,12 have demonstrated a high degree of heritability for ROM and otitis media (OM) duration. We conducted a linkage study (the Minnesota COME/ROM Family Study 13 ) that revealed evidence for linkage to COME and ROM on chromosome 10q and suggestive evidence for linkage on chromosome 19q.…”

mentioning

confidence: 99%

Association of the FBXO11 Gene With Chronic Otitis Media With Effusion and Recurrent Otitis Media

Segade

Daly²,

Allred³

et al. 2006

Arch Otolaryngol Head Neck Surg

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The FBXO11 gene is the human homologue of the gene mutated in the novel deaf mouse mutant jeff (Jf), a single gene model of otitis media. We have evaluated single nucleotide polymorphisms (SNPs) in the FBXO11 gene for association with chronic otitis media with effusion/recurrent otitis media (COME/ROM).Design: A total of 13 SNPs were genotyped across the 98.7 kilobases of genomic DNA encompassing FBXO11. Data were analyzed for single SNP association using generalized estimating equations, and haplotypes were evaluated using Pedigree Disequilibrium Test methods. Patients: The Minnesota COME/ROM Family Study, a group of 142 families (619 subjects) with multiple affected individuals with COME/ROM. Main Outcome Measures: Genetic association of COME/ROM with polymorphisms in FBXO11.Results: The FBXO11 SNPs are contained in a single linkage disequilibrium haplotype block. Ten of the 13 SNPs were sufficiently polymorphic in the sample to permit analysis. In univariate genetic analysis, 1 reference SNP (hereinafter rs) (rs2134056) showed nominal evidence of association to COME/ROM (P=.02), and 2 SNPs approached significance (rs2020911, P = .06; rs3136367, P=.09). In multivariable analyses, including known risk factors for COME/ROM (sex, exposure to smoking, attending day care centers, no prior breastfeeding, and having allergies), the evidence of independent association was reduced for each SNP (eg, rs2134056, from P=.02 to P=.08). In subsequent analyses using the Pedigree Disequilibrium Test, the association of FBXO11 SNP rs2134056 (P=.06) with COME/ROM was confirmed. Incorporating multiple SNPs in 2-and 3-locus SNP haplotypes, those haplotypes containing rs2134056 also exhibited evidence of association of FBXO11 and COME/ ROM (P values ranging from .03 to .10). Conclusion:We have observed evidence consistent with an association between polymorphisms in FBXO11, the human homologue of the Jeff mouse model gene, and COME/ROM.

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“…Therefore, if household smoking is associated with the risk of middle ear disease, there should also be a relationship between socio-economic factors and these diseases. However, only 6 of the studies [24,28,34,45,47,48] found an association between socio-economic status and the incidence of middle ear diseases, although raised relative risks were found for various other factors which may be indicative of lower social class.…”

Section: Discussionmentioning

confidence: 99%

“…Tobacco smoke may also have an indirect effect via the child's respiratory system, either through a reduction in immune response resulting in more frequent respiratory illnesses [2,17,19,68,69,73,76,82,94,98], or through cross-infection from adult smokers who may themselves suffer an increased frequency of respiratory infections [17,19,47,70,73,101,102]. It has been suggested that this second pathway may be a more important cause of respiratory illnesses than a direct effect of tobacco smoke on the child's own respiratory system [19].…”

Section: Discussionmentioning

confidence: 99%

“…Three studies [6,8,15] stated that parental smoking habits were recorded at the beginning of the study period only, 4 studies [4,33,40,53] recorded parental smoking habits at the end of the study period only, 1 study [43] collected information at the beginning or at the end of the study only, 1 study [32] collected information at the beginning of the study or at the birth of the child, while in 5 other studies [12,22,35,51,56], the time at which the information was collected was not stated. The remaining studies [10,13,18,21,24,27,34,46,47,55,58] recorded parental smoking habits throughout the study period.…”

Section: Misclassification Of Exposurementioning

confidence: 99%

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Parental Smoking and Middle Ear Disease in Children: A Review of the Evidence

Thornton

1999

Indoor Built Environ

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This report presents a detailed review of the available epidemiological evidence concerning the prevalence of middle ear infections in children in relation to their exposure to smoking by their parents or other household members and is based on English-language papers covering the period 1979–1998. Fifty-eight studies are included in the review, with the most widely used index of exposure being parental smoking. Smoking by all household members, by either parent separately and by the mother during pregnancy were also considered in some of the studies. Only 3 studies attempted to quantify exposure objectively, using measurements of cotinine and nicotine in hair, saliva and pericardial fluid. Tables listing unadjusted and adjusted relative risk estimates were constructed for both postnatal exposure to tobacco smoke and for maternal smoking during pregnancy. The results for postnatal exposure were separated into five disease categories. The overall data suggested some association of postnatal exposure to tobacco smoke with three categories; recurrent otitis media, otitis media with effusion and unspecified middle ear disease, with risk tending to increase with increasing exposure, but no association with acute otitis media or with persistent otitis media with effusion. However, reported associations were generally quite weak, with relative risks typically below 1.5. Problems in interpreting the data arise from the difficulty of distinguishing possible effects of environmental tobacco smoke and of maternal smoking during pregnancy (for which the data also suggest an association), the possibility that the underlying cause of middle ear disease is in fact an infection, and from the various possibilities of bias inherent in epidemiological studies of a weak association, particularly due to inadequate control of confounding. Though it is prudent for parents not to expose their children to high doses of environmental tobacco smoke for long periods, the overall epidemiological evidence does not convincingly demonstrate that exposure to environmental tobacco smoke increases the incidence of middle ear diseases in children.

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The bayesian approach to the evaluation of risk factors in acute and recurrent acute otitis media

Cited by 78 publications

References 13 publications

Racial/Ethnic and socioeconomic disparities in the prevalence and treatment of otitis media in children in the United States

Racial/Ethnic and socioeconomic disparities in the prevalence and treatment of otitis media in children in the United States

Association of the FBXO11 Gene With Chronic Otitis Media With Effusion and Recurrent Otitis Media

Parental Smoking and Middle Ear Disease in Children: A Review of the Evidence

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