The behavior, attitude, and knowledge towards photoprotection in patients with cutaneous/systemic lupus erythematosus: a comparative study with 526 patients and healthy controls

Chanprapaph, Kumutnart; Ploydaeng, Monthanat; Pakornphadungsit, Kallapan; Mekwilaiphan, Thiraphong; Vachiramon, Vasanop; Kanokrungsee, Silada

doi:10.1039/d0pp00073f

Cited by 11 publications

(10 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A valid explanation is that patients with cutaneous lesions have had direct exposure to sunlight, exacerbating their cutaneous disease, which raises the motivation for them to implement a more rigorous photoprotection measure. 29 A study conducted in Singapore also demonstrated serum 25(OH)D less than 20 ng/mL (deficiency) in 51% of CLE patients, which is slightly more than our study (33.3%). 30 The reason why Singaporeans had higher vitamin D deficiency may contribute to the genetic factors and variety of ethnicity, where the majority were Malay and Indian with darker skin types, and the higher melanin content may have resulted in limited vitamin D biosynthesis.…”

Section: Discussioncontrasting

confidence: 63%

High Prevalence of Hypovitaminosis D in Cutaneous and Systemic Lupus Erythematosus Patients and Its Associated Factors: A Cross-Sectional Study in Thailand

Kanokrungsee¹,

Patcharapojanart²,

Suchonwanit³

et al. 2022

CCID

Self Cite

View full text Add to dashboard Cite

Objective To investigate the prevalence of low vitamin D levels in patients with cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE) in Thailand and determine the influential factors associated with inadequate levels. Methods The medical records of patients diagnosed with SLE and/or CLE and evaluated for serum 25-OH vitamin D were retrospectively reviewed from January 2014 to January 2021. Vitamin D deficiency (<20 ng/mL) and insufficiency (21–29 ng/mL) were indicated, and predictors of hypovitaminosis D were identified by multiple linear regression analysis. Results In total, 414 patients with SLE and/or CLE were included in the study. Vitamin D deficiency was predominant in the CLE-only group (33.3%), followed by SLE without CLE (15.6%) and SLE with CLE (8%), p < 0.001. Likewise, vitamin D insufficiency was more prevalent in the CLE-only group (44.4%) compared to SLE with (35.8%) and without CLE (40%). Multivariate analysis showed that a higher SLEDAI-2K score and female sex had a negative association with vitamin D levels, while an intake of every 10,000 IU of vitamin D2 per week increased serum vitamin D levels by up to 2.37 ng/mL. Furthermore, forty-five percent of patients continued to have vitamin D depletion despite commencing the recommended doses of vitamin D replacement. Conclusion Approximately half of Thai patients with SLE and 80% of CLE had vitamin D inadequacy. Vitamin D replacement is a good predictor of high serum vitamin D levels, while lower serum levels were associated with higher disease severity. Therefore, serum vitamin D monitoring and supplementation are suggested for all lupus erythematosus cases, especially those with CLE.

show abstract

Section: Discussioncontrasting

confidence: 63%

High Prevalence of Hypovitaminosis D in Cutaneous and Systemic Lupus Erythematosus Patients and Its Associated Factors: A Cross-Sectional Study in Thailand

Kanokrungsee¹,

Patcharapojanart²,

Suchonwanit³

et al. 2022

CCID

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…Ultraviolet light is a well-recognised trigger for lupus; 39 40 therefore, even if our results indicate a relatively benign course of disease in patients with self-reported photosensitivity (fast ultraviolet reaction), photoprotection is still essential, especially in patients without selfreported photosensitivity, by whom photoprotection is more likely to be ignored. 41 Generalised ACLE is a more severe state than localised ACLE; CHLE is a more severe state than DLE Large cohorts focusing on subtypes of LE-specific cutaneous manifestations (ACLE/SCLE/CCLE) are rare, and studies focusing on comparisons of more detailed subtypes (localised ACLE/generalised ACLE/annular SCLE/papulosquamous SCLE/DLE/CHLE/LEP) are lacking. Our study provided a comparison of detailed subtypes of LE-specific cutaneous manifestations in a larger sample.…”

Section: Discussionmentioning

confidence: 99%

Panoramic view of clinical features of lupus erythematosus: a cross-sectional multicentre study from China

Jin

Zhou

et al. 2023

Lupus Sci Med

View full text Add to dashboard Cite

ObjectiveLupus erythematosus (LE) is a complicated disease with highly heterogeneous clinical manifestations. Previous studies have rarely included all subgroups of patients with lupus and have overlooked the importance of the cutaneous manifestations thereof. We aimed to compare the demographic and clinical differences among patients with different subtypes of lupus.MethodsThis is the first real-world study with a relatively large sample size that simultaneously includes patients with isolated cutaneous lupus erythematosus (iCLE) and SLE. All samples were obtained from the Lupus Erythematosus Multicenter Case–control Study in Chinese populations (LEMCSC) (registration number: ChiCTR2100048939). Comparative analyses between different LE subgroups were performed.ResultsA total of 2097 patients with lupus were included, with 1865 patients with SLE, 1648 with cutaneous lupus erythematosus (CLE), and 232 with iCLE. Among the patients with CLE, 1330 had acute cutaneous lupus erythematosus (ACLE); 160 had subacute cutaneous lupus erythematosus (SCLE); and 546 had chronic cutaneous lupus erythematosus (CCLE). The study included a relatively large number of patients with CCLE subtypes, including 311 with discoid lupus erythematosus (DLE), 262 with chilblain lupus erythematosus (CHLE) and 45 with lupus erythematosus profundus (LEP). Demographic characteristics, systemic involvement, mucocutaneous manifestations and autoantibodies were significantly different among the groups.ConclusionsCLE and iCLE are two distinct disease states, and the selection of broad or narrow CLE definitions should be emphasised in scientific reports. LE-non-specific cutaneous lesions imply more severity, while self-reported photosensitivity and LE-specific cutaneous manifestations imply milder severity. Generalised ACLE appears to be a more severe state than localised ACLE, and CHLE appears to be more severe than DLE. Anti-Sjögren’s syndrome-related antigen B (SSB) antibodies have higher specific directivity than anti-Sjögren’s syndrome-related antigen A (SSA) antibodies for SCLE lesions. Anti-double-stranded DNA antibodies have a higher co-occurrence with ACLE and a lower co-occurrence with SCLE and CCLE. Compared with DLE, CHLE has significantly higher positive rates of anti-SSA/Ro60 (71%) and anti-SSA/Ro52 (42.4%) antibodies, whereas LEP is associated with a higher positive rate of antinucleosome antibodies (31.1%).

show abstract

“…The questionnaire was also used to assess patients’ knowledge and behaviors regarding photoprotection. Photoprotection knowledge was evaluated using a set of 13 questions in Korean (see Table S1), referring to previous studies including CHASE questionnaire in Spain 22–25 . Patients were asked to answer “True” or “False” for each question and each patient's score was determined by the number of correct responses, ranging from 0 to 13.…”

Section: Methodsmentioning

confidence: 99%

Knowledge and the behavioral patterns of photoprotection among Koreans with skin disease

Jo,

Kim,

Lee

et al. 2024

Photoderm Photoimm Photomed

View full text Add to dashboard Cite

BackgroundPhotoprotection is crucial in preventing the development and progression of various skin diseases. However, patients with skin disease have limited awareness of photoprotection. We evaluated the knowledge and behavioral patterns of photoprotection among Koreans with skin diseases.MethodsA cross‐sectional study was conducted in 11 general hospitals across South Korea. The study population consisted of patients aged 19 years or older who visited dermatologic clinics for their skin diseases. A self‐administered questionnaire was used to collect patient demographics, knowledge of photoprotection, and photoprotective habits.ResultsIn this study, 1173 patients with skin cancer, hyperpigmentary disorders, hypopigmentary disorders, or other skin diseases participated. Females scored significantly higher in knowledge of photoprotection compared to males (mean score 8.4 vs. 7.8; p < .001), and younger patients (<50 years) scored higher than older patients (mean score 8.7 vs. 7.5; p < .001). Males also reported longer sun exposure times and lower usage of photoprotective measures (both p < .001). Patients with skin cancer had the lowest mean knowledge score (7.1 ± 2.6) and were less likely to use photoprotective measures compared to other groups (p < .001). In contrast, patients with hyperpigmentation actively avoided sun exposure compared with other groups (p < 0.001).ConclusionsKnowledge of photoprotection among Korean patients with skin diseases varied depending on the gender, age, and type of skin disease. Their photoprotective behaviors were inadequate, especially among males and those with skin cancer. These findings emphasize the importance of educating and tailoring photoprotection strategies for patients with skin diseases.

show abstract

The behavior, attitude, and knowledge towards photoprotection in patients with cutaneous/systemic lupus erythematosus: a comparative study with 526 patients and healthy controls

Abstract: Objective: To evaluate the attitude, knowledge and behavior toward sun protection in systemic lupus erythematosus (SLE) patients with and without cutaneous involvement (CLE) compared to non-photosensitive controls and to determine...

Cited by 11 publications

References 32 publications

High Prevalence of Hypovitaminosis D in Cutaneous and Systemic Lupus Erythematosus Patients and Its Associated Factors: A Cross-Sectional Study in Thailand

High Prevalence of Hypovitaminosis D in Cutaneous and Systemic Lupus Erythematosus Patients and Its Associated Factors: A Cross-Sectional Study in Thailand

Panoramic view of clinical features of lupus erythematosus: a cross-sectional multicentre study from China

Knowledge and the behavioral patterns of photoprotection among Koreans with skin disease

Contact Info

Product

Resources

About