This paper presents the results of extensive numerical simulations, based on the control volume method, of 2D nanofluid fluid flow around a heated elliptical cylinder with different incidence angle and aspect ratio. The continuity and momentum equations have been numerically solved using a SIMPLE algorithm. Two types of nanofluids consisting of Al 2 O 3 and CuO nanoparticles dispersed separately in base fluids of water and ethylene glycol mixture 60:40 (by mass), were selected to evaluate their effect on the flow over elliptical cylinder, also their superiority over conventional fluids. The thermo-physical parameters of nanofluid have been estimated using the theory of one fluid phase, a contemporary correlations of thermal conductivity and viscosity of nanofluids have been used in this paper, which are functions of particle volumetric concentration as well as temperature. The results of heat transfer characteristics of nanofluid flow over elliptical cylinder reveled clear improvement comparing with the base fluids. This enhancement is more important in flows with different geometry characteristics of the elliptical cylinder. While the aspect ratio and the incidence angle, exert significant influence on the heat transfer characteristics. The obtained results indicate that the use of aspect ratio 0.83 and incidence angle 79.2° lead to the highest amounts of heat transfer inside the tube.