The Behavior of the Type of Peritoneal Transport in the Inflammatory and Oxidative Status in Adults Under Peritoneal Dialysis

Gutierrez-Prieto, J. A.; Soto-Vargas, Javier; Parra-Michel, Renato; Pazarín-Villaseñor, H. Leonardo; García-Sánchez, Andrés; Miranda-Díaz, Alejandra Guillermina

doi:10.3389/fmed.2019.00210

Cited by 4 publications

(5 citation statements)

References 63 publications

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“…Further, the accumulation of ROS is associated with the pathogenesis of CKD [ 38 , 39 , 40 , 41 ] and influences cellular function and mortality in PD patients [ 1 , 42 , 43 , 44 , 45 ]. Our results showing increased oxidative DNA-damage are consistent with previous studies demonstrating increased damage due to attenuated defense mechanisms [ 7 , 46 ] and studies showing that both hemodialysis and peritoneal dialysis induces oxidative DNA-damage in patients or in peritoneal mesothelial cells of PD patients [ 44 , 47 , 48 , 49 ]. In addition, previous studies from our group demonstrated that ESRD patients showed reduced expression of MT presuming a disbalance in redox homeostasis leading to increased oxidative damage [ 24 , 35 ].…”

Section: Discussionsupporting

confidence: 92%

Enhanced Oxidative DNA-Damage in Peritoneal Dialysis Patients via the TXNIP/TRX Axis

et al. 2022

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Peritoneal dialysis (PD) is an effective method of renal replacement therapy, providing a high level of patient autonomy. Nevertheless, the long-term use of PD is limited due to deleterious effects of PD fluids to the structure and function of the peritoneal membrane leading to loss of dialysis efficacy. PD patients show excessive oxidative stress compared to controls or chronic kidney disease (CKD) patients not on dialysis. Therefore, defense systems against detrimental events play a pivotal role in the integrity of the peritoneal membrane. The thioredoxin-interacting-protein (TXNIP)/thioredoxin (TRX) system also plays a major role in maintaining the redox homeostasis. We hypothesized that the upregulation of TXNIP negatively influences TRX activity, resulting in enhanced oxidative DNA-damage in PD patients. Therefore, we collected plasma samples and human peritoneal biopsies of healthy controls and PD patients as well. Using ELISA-analysis and immunohistochemistry, we showed that PD patients had elevated TXNIP levels compared to healthy controls. Furthermore, we demonstrated that PD patients had a reduced TRX activity, thereby leading to increased oxidative DNA-damage. Hence, targeting the TXNIP/TRX system as well as the use of oxidative stress scavengers could become promising therapeutic approaches potentially applicable in clinical practice in order to sustain and improve peritoneal membrane function.

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Section: Discussionsupporting

confidence: 92%

Enhanced Oxidative DNA-Damage in Peritoneal Dialysis Patients via the TXNIP/TRX Axis

et al. 2022

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“…Major limitations of this study is that it is an unicentric, cross-sectional and a small sample size. The lower enzymatic antioxidant defense in dialysis patients versus HC subjects was reported before, as was the lack of differences between HD and CAPD with respect to antioxidant systems [15] [16] [17].…”

Section: Discussionmentioning

confidence: 79%

“…The HD therapy itself increases OS [12] and leads to NO inactivation and deficiency [13], which might contribute to a high risk of CVD in HD patients. Moreover, the type of membrane used in HD (artificial) [14] or CAPD (natural filter, the peritoneum) [15] [16] can contribute to the formation of ROS. In this way, HD can lead to the contamination of the dialysis solution and stimulate neutrophils to produce more ROS [15] and may generate more OS when compared to CAPD.…”

Section: Introductionmentioning

confidence: 99%

Antioxidants Enzymes Activities and NO Levels in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis—A Comparative Study

Ribeiro,

Tavares,

da Silva

et al. 2024

JBM

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It consists of a retrospective study with twenty-two individuals diagnosed with DRC: fourteen HD and eight CAPD, followed up in the dialysis center of Antonio Pedro University Hospital (HUAP) of Fluminense Federal University (UFF), between 2015 and 2017. Fifteen healthy control (HC) subjects were included, without diagnosed CKD. Patients with HIV positive, hepatitis A, B, and C, pregnant, cancer, smokers, alcoholics and those exposed to X-rays in the last 3 months, were excluded. Objectives: As oxidative stress and endothelial dysfunction may be linked to the higher prevalence of CVD in CKD patients, we measured the activities of the antioxidants enzymes: SOD and GPx and total NO levels in the plasma and serum of end-stage CKD patients undergoing dialysis therapy, comparing with the HC group. Methods: Quantification of NO levels was performed by fluorometric kit, while activities of SOD and GPx were determined using kinetic methods. Results: We found higher plasma SOD activity in HD (8.58 U/ml) and CAPD (10.14 U/ml), compared to C (3.73 U/ml) group, while GPx activity was decreased in HD (115.38 nmol/h/ml) and CAPD (122.76 nmol/h/ml) groups compared to HC group (275.83 nmol/h/ml). Total serum NO concentration was decreased in HD (14.09 pmol/µl) and CAPD (10.26 pmol/µl), compared to non-CKD patients (49.65 pmol/µl). Conclusion: Decreased total serum NO and GPx activities may lead to endothelial dysfunction and consequently a higher prevalence of CVD in CKD patients.

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“…High levels of pro-inflammatory cytokines and certain oxidants can decrease the activity of the DNA repair enzyme, especially in patients with ESRD ( 41 , 42 ). The authors of a recent publication reported the downregulation of DNA repair enzymes in patients dependent on the type of peritoneal transport ( 43 ). Significant increase in oxidative DNA damage repair enzyme levels in patients treated with sevelamer hydrochloride, at 6 months of follow-up, is notable, especially in those who ingested 1,600 mg of the phosphate binder.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Sevelamer Hydrochloride and Calcium Carbonate on Markers of Inflammation and Oxidative Stress in Hemodialysis at Six Months of Follow-Up

et al. 2021

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Patients with end-stage renal disease (ESRD) present alterations in mineral and bone metabolism. Hyperphosphatemia in ESRD is considered an independent risk factor for cardiovascular disease (CVD), increasing morbidity, and mortality. Sevelamer hydrochloride is a calcium-free, non-absorbable phosphate-chelating polymer. Calcium carbonate chelator is helpful in controlling serum phosphate levels. There is insufficient information on the influence of sevelamer hydrochloride and calcium carbonate on the behavior of oxidative stress (OS) markers and inflammation in patients on hemodialysis (HD). A randomized open clinical trial was carried out on patients to evaluate sevelamer hydrochloride and calcium carbonate influence at 6 months of study follow-up. Levels of oxidants (LPO, NO, and 8-isoprostanes), antioxidants (SOD and TAC), oxidative DNA damage (8-OHdG and hOGG1), pro-inflammatory cytokines (IL-6 and TNF-α), and inflammation markers (ferritin and C-reactive protein) were measured with colorimetric and ELISA methods. We found a significant increase in oxidants LPO and NO, and antioxidants SOD and TAC, and downregulation of IL-6 and TNF-α. Ferritin decrease at 6 months follow-up in the sevelamer hydrochloride group. Increase in C-reactive protein was found in the group of patients treated with calcium carbonate. In conclusion, we found an oxidative state imbalance with increase in LPO and NO oxidants. The activity of the antioxidant enzymes (SOD and TAC) was also found to increase, suggesting a compensatory effect in the face of increase in oxidants. The same phenomenon was observed with increase in the oxidative damage marker to DNA and the increase in the DNA repair enzyme, suggesting a compensatory effect. Pro-inflammatory cytokines were predominantly downregulated by TNF-α in the group that ingested sevelamer hydrochloride in the final determination at 6 months of follow-up. Serum ferritin levels decreased significantly at the end of follow-up in patients on HD in the sevelamer hydrochloride group. The management of hyperphosphatemia with sevelamer hydrochloride appears to have obvious anti-inflammatory and antioxidant benefits.

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The Behavior of the Type of Peritoneal Transport in the Inflammatory and Oxidative Status in Adults Under Peritoneal Dialysis

Cited by 4 publications

References 63 publications

Enhanced Oxidative DNA-Damage in Peritoneal Dialysis Patients via the TXNIP/TRX Axis

Enhanced Oxidative DNA-Damage in Peritoneal Dialysis Patients via the TXNIP/TRX Axis

Antioxidants Enzymes Activities and NO Levels in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis—A Comparative Study

The Influence of Sevelamer Hydrochloride and Calcium Carbonate on Markers of Inflammation and Oxidative Stress in Hemodialysis at Six Months of Follow-Up

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