This review focuses on neuroimaging studies that examined stress processing and regulation and cognitive inhibitory control in patients with psycho-stimulant addiction. We provide an overview of these studies, summarizing converging evidence and discrepancies as they occur in the literature. We also adopt an analytic perspective and dissect these psychological processes into their subcomponents, to identify the neural pathways specific to each component process and those that are more specifically involved in psycho-stimulant addiction. To this aim we refer frequently to studies conducted in healthy individuals. Despite the separate treatment of stress/affect regulation, stressrelated craving or compulsive drug seeking, and inhibitory control, neural underpinnings of these processes overlap significantly. In particular, the ventromedial prefrontal regions including the anterior cingulate cortex, amygdala and the striatum are implicated in psychostimulant dependence. Our overarching thesis is that prefrontal activity ensures intact emotional stress regulation and inhibitory control. Altered prefrontal activity along with heightened striatal responses to addicted drug and drug-related salient stimuli perpetuates habitual drug seeking. Further studies that examine the functional relationships of these neural systems will likely provide the key to understanding the mechanisms underlying compulsive drug use behaviors in psycho-stimulant dependence. Keywords fMRI; cognitive control; reward; motivation; affect; impulsivity; decision making; cocaine; methamphetamine The molecular and cellular neurobiology of drug addiction has recently been extensively reviewed in the literature (Di Chiara and Bassareo, 2007;Kalivas et al., 2005;Koob, 2006;Maldonado et al., 2006). Drawing heavily on rodent studies, previous reviews of the neuroscience of drug addiction have elaborated on the role of cortico-striatal pathways and extended amygdala circuitry in shaping habitual and compulsory drug use behaviors (Everitt et al., 2001;Everitt and Robbins, 2005;Everitt and Wolf, 2002;Koob, 2003;Koob, 2006; Address correspondence to: Dr. Chiang-shan Ray Li, Assistant Professor, Connecticut Mental Health Center, S103, Department of Psychiatry, Yale University School of Medicine, 34 Park Street New Haven, CT 06519,. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
NIH Public Access
Author ManuscriptNeurosci Biobehav Rev. Author manuscript; available in PMC 2009 January 1.
Published in final edited form as:Neurosci Biobehav Rev. 2008 ; 32(3): 581-597.
NIH-PA Author ManuscriptNIH-PA Author Manusc...