The behaviour of magnetic spherical particles and the heating effect in a rotating magnetic field via Brownian dynamics simulations

Suzuki, Seiya; Satoh, Akira; Futamura, Muneo

doi:10.1080/00268976.2021.1892225

Cited by 10 publications

(2 citation statements)

References 20 publications

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“…The clustering of magnetic particles is one of the major factors that alters/enhances the hyperthermia properties, which is caused by the fluctuating hysteresis loss. [300][301][302][303] The factor by which and how the clusters affect the magnetic hyperthermia efficiency depend on the shape/morphology, [300][301][302] easy axes, 301,304 damping factor of particle shape/size/length, 305 magnetic anisotropy 302 and magnetic field orientation to the clusters. 300 Interestingly, the dipole-dipole interaction is a key player affecting all the physical parameters of clusters either directly or indirectly.…”

Section: Discussionmentioning

confidence: 99%

The Curie temperature: a key playmaker in self-regulated temperature hyperthermia

Niraula,

Wu,

et al. 2024

J. Mater. Chem. B

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Section: Discussionmentioning

confidence: 99%

The Curie temperature: a key playmaker in self-regulated temperature hyperthermia

Niraula,

Wu,

et al. 2024

J. Mater. Chem. B

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“…However, superparamagnetic nanoparticles have very low Coercivity (Hc) and magnetic remanence (Mr) (near zero). Therefore, the heat generated by hysteresis loss will be negligible [3,7]. Among NMPs, iron oxide is used for cancer hyperthermia due to its biocompatibility, high magnetic saturation, and superparamagnetic behavior.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Core@shell Structures of Glycerin@Fe3O4, and Al2O3@Fe3O4 Nanoparticles for Use in Hyperthermia Therapy

Samakosh,

Bahari,

Hamidabadi

et al. 2023

BioNanoSci.

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Fe 3 O 4 magnetic nanoparticles (MNPs) have received a great deal of attention in biomedical applications due to their high magnetic sensitivity, large surface area, and superparamagnetic behavior. Their low stability, toxicity, and severe accumulation tendency in aqueous media have, however, hindered their application in hyperthermia treatments. This problem can be resolved by the incorporation of nonmagnetic and biocompatible shells on Fe 3 O 4 . The aim of this research is thus the introduction of Glycerin and Aluminum oxide (Al 2 O 3 ) as two proper materials for coating Fe 3 O 4 and the investigation of their e ciency in this eld. The results indicated that Glycerin@Fe 3 O 4 and Al 2 O 3 @Fe 3 O 4 have a core@shell structure and superparamagnetic features with relatively high saturation magnetization (M S ). The cytotoxicity of the synthesized nanoparticles was evaluated on normal broblast and lung cancer cell lines (A54912) for 24 and 48 hours using the MTT assay. The viability of the A54912 and broblast cell lines in the presence of Fe 3 O 4 was signi cantly lower than the two coated nanoparticles. This implies that the Glycerin and Al 2 O 3 provided the Fe 3 O 4 nanoparticles with proper biocompatibility. The effectiveness of the synthesized NPs in magnetic hyperthermia was evaluated by exposure of the nanoparticle solutions in water (0.2 and 0.4 mg/ml) to a high-frequency alternating magnetic eld for 30 min. the results indicated the achievement of treatment temperature (42-46 ℃) in a short time and elimination of a large percentage of the A54912 cells. In this regard, the present research reported the promising e cacy and e ciency of Glycerin@Fe 3 O 4 and Al 2 O 3 @Fe 3 O 4 in hyperthermia-based cancer treatment.

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Reversible Alignment of Nanoparticles and Intracellular Vesicles During Magnetic Hyperthermia Experiments

Fernández‐Afonso,

Ruta,

Páez‐Rodríguez

et al. 2024

Adv Funct Materials

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Heating magnetic nanoparticles (MNPs) with AC (Alternating Current) magnetic fields has received significant attention in recent years, particularly for biomedical uses. However, most studies focus on characterizing the heat release, overlooking the fact that the MNPs in the viscous cell environment constitute a dynamic magnetic colloid whose configuration may evolve over time, particularly if a driving force as the AC field is applied. Aiming to shed light on this matter, in this workthe dynamics of the colloid structure during hyperthermia experiments are studied. By combining various experimental and theoretical tools, it is concluded that the AC field may drive the formation of aligned structures, and the impact that such structures may have on the associated heating is assessed. Remarkably, the results show that those field‐driven structures are highly unstable for small particle sizes, rapidly disassembling upon field removal. Moreover, an analogous behavior in vitro is found, with the AC magnetic field also promoting a reversible alignment of vesicles containing the MNPs within the cells. The results suggest that the observed alignment, both of MNPs and intracellular vesicles, may be a common phenomenon in usual hyperthermia experiments, but unnoticed because of the intrinsic unstable nature of the aligned structures.

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The behaviour of magnetic spherical particles and the heating effect in a rotating magnetic field via Brownian dynamics simulations

Cited by 10 publications

References 20 publications

The Curie temperature: a key playmaker in self-regulated temperature hyperthermia

The Curie temperature: a key playmaker in self-regulated temperature hyperthermia

Preparation and Characterization of Core@shell Structures of Glycerin@Fe3O4, and Al2O3@Fe3O4 Nanoparticles for Use in Hyperthermia Therapy

Reversible Alignment of Nanoparticles and Intracellular Vesicles During Magnetic Hyperthermia Experiments

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