The recent development of metallic glass-matrix composites represents a particular milestone in engineering materials for structural applications owing to their remarkable combination of strength and toughness. However, metallic glasses are highly susceptible to cyclic fatigue damage, and previous attempts to solve this problem have been largely disappointing. Here, we propose and demonstrate a microstructural design strategy to overcome this limitation by matching the microstructural length scales (of the second phase) to mechanical crack-length scales. Specifically, semisolid processing is used to optimize the volume fraction, morphology, and size of second-phase dendrites to confine any initial deformation (shear banding) to the glassy regions separating dendrite arms having length scales of Ϸ2 m, i.e., to less than the critical crack size for failure. Confinement of the damage to such interdendritic regions results in enhancement of fatigue lifetimes and increases the fatigue limit by an order of magnitude, making these ''designed'' composites as resistant to fatigue damage as high-strength steels and aluminum alloys. These design strategies can be universally applied to any other metallic glass systems.composites ͉ damage confinement ͉ endurance limit ͉ semisolid processing M onolithic bulk metallic glasses (BMGs) have emerged over the past 15 years as a class of materials with unique and unusual properties that make them potential candidates for many structural applications (1). These properties include their near theoretical strengths combined with high formability, low damping, large elastic strain limits, and the ability to be thermoplastically formed into precision net shape parts in complex geometries (2, 3), all of which are generally distinct from, or superior to, corresponding crystalline metals and alloys. However, monolithic BMGs can also display less desirable properties that have severely restricted their structural use. In particular, properties limited by the extension of cracks, such as ductility, toughness, and fatigue, can be compromised in BMGs by inhomogeneous plastic deformation at ambient temperatures where plastic flow is confined in highly localized shear bands (4, 5). Such severe strain localization with the propagation of the shear bands is especially problematic under tensile stress states where catastrophic failure can ensue along a single shear plane with essentially zero macroscopic ductility (6, 7). Consequently, resulting plane-strain K Ic fracture toughnesses in monolithic BMGs are often low (Ϸ15-20 MPa ͌ m), as compared with most crystalline metallic materials, although they are an order of magnitude larger than those for (ceramic) oxide glasses (8, 9). If such strain localization is suppressed such that plastic flow is allowed to be extensive, for example, by blunting the crack tip, then damage would be distributed over larger dimensions with toughness values increasing to Ϸ50 MPa ͌ m or more (8, 10). Whereas some metallic glasses appear to be intrinsically brittle in thei...