The Beneficial and Adverse Effects of Autophagic Response to Caloric Restriction and Fasting

Shabkhizan, Roya; Haiaty, Sanya; Moslehian, Marziyeh Sadat; Bazmani, Ahad; Sadeghsoltani, Fatemeh; Bagheri, Hesam Saghaei; Rahbarghazi‬, Reza; Sakhinia, Ebrahim

doi:10.1016/j.advnut.2023.07.006

Cited by 25 publications

(4 citation statements)

References 150 publications

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“…Many types of cancer cells are not able to execute changes that would allow survival in a nutrient-deficient and toxic environment [ 32 ]. Moreover, accumulated evidence suggests that calorie restriction can produce an adaptive autophagic response, while prolonged autophagy overstimulation leads to type II autophagic cell death [ 33 ]. At the early stages of tumor development, autophagy inhibits tumor growth, while later during the cancer progression, it may promote the survival of tumor cells [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Antitumor Effects of an Anthocyanin-Rich Grain Diet in a Mouse Model of Lewis Lung Carcinoma

Tikhonova,

Shoeva,

Tenditnik

et al. 2024

IJMS

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Functional foods enriched with plant polyphenol anthocyanins attract particular attention due to their health-promoting properties, including antitumor activity. We evaluated the effects of a grain diet rich in anthocyanins in a mouse model of Lewis lung carcinoma. Mice of the C57BL/6 strain were fed with wheat of near-isogenic lines differing in the anthocyanin content for four months prior to tumor transplantation. Although a significant decrease in the size of the tumor and the number of metastases in the lungs was revealed in the groups with both types of grain diet, the highest percentage of animals without metastases and with attenuated cell proliferation in the primary tumor were observed in the mice with the anthocyanin-rich diet. Both grain diets reduced the body weight gain and spleen weight index. The antitumor effects of the grain diets were associated with the activation of different mechanisms: immune response of the allergic type with augmented interleukin(IL)-9 and eotaxin serum levels in mice fed with control grain vs. inhibition of the IL-6/LIF system accompanied by a decrease in the tumor-associated M2 macrophage marker arginase 1 gene mRNA levels and enhanced autophagy in the tumor evaluated by the mRNA levels of Beclin 1 gene. Thus, anthocyanin-rich wheat is suggested as a promising source of functional nutrition with confirmed in vivo antitumor activity.

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Section: Discussionmentioning

confidence: 99%

Antitumor Effects of an Anthocyanin-Rich Grain Diet in a Mouse Model of Lewis Lung Carcinoma

Tikhonova,

Shoeva,

Tenditnik

et al. 2024

IJMS

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“…Recent studies have shown that although intermittent fasting and CR can stimulate adaptative macroautophagy and increase longevity, in certain instances, prolonged CR can stimulate macroautophagic cell death ( 69 ). Although the molecular mechanism behind this switch from adaptative to detrimental autophagy remains unclear, there seems to be a relation with the underlying energetic status of the cell.…”

Section: Discussionmentioning

confidence: 99%

Calorie restriction and calorie-restriction mimetics activate chaperone-mediated autophagy

Jafari,

Macho-González,

Diaz

et al. 2024

Proc. Natl. Acad. Sci. U.S.A.

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Chaperone-mediated autophagy (CMA) is part of the mammalian cellular proteostasis network that ensures protein quality control, maintenance of proteome homeostasis, and proteome changes required for the adaptation to stress. Loss of proteostasis is one of the hallmarks of aging. CMA decreases with age in multiple rodent tissues and human cell types. A decrease in lysosomal levels of the lysosome-associated membrane protein type 2A (LAMP2A), the CMA receptor, has been identified as a main reason for declined CMA in aging. Here, we report constitutive activation of CMA with calorie restriction (CR), an intervention that extends healthspan, in old rodent livers and in an in vitro model of CR with cultured fibroblasts. We found that CR-mediated upregulation of CMA is due to improved stability of LAMP2A at the lysosome membrane. We also explore the translational value of our observations using calorie-restriction mimetics (CRMs), pharmacologically active substances that reproduce the biochemical and functional effects of CR. We show that acute treatment of old mice with CRMs also robustly activates CMA in several tissues and that this activation is required for the higher resistance to lipid dietary challenges conferred by treatment with CRMs. We conclude that part of the beneficial effects associated with CR/CRMs could be a consequence of the constitutive activation of CMA mediated by these interventions.

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“…39,40 Researchers have also investigated fasting's influence on autophagy, and some studies suggest that intermittent fasting significantly upregulates autophagy. [41][42][43][44] Factors that Link Fasting to Autophagy Fasting is a condition when the cells are starved of nourishment. In such a situation, the intracellular turnover rate of proteins and organelles increases.…”

Section: Potential Effects Of Fasting On the Human Bodymentioning

confidence: 99%

Potential of Medium to Long-Term Fasting to Trigger an Autoimmune Response Through Hyperaggressive Autophagy

Saxena,

Saxena

2023

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Intermittent fasting is a lifestyle intervention that is increasingly gaining traction among the general population. An enhancement in the rate of autophagy is one of the fundamental results of intermittent fasting. Autophagy is a principal intracellular strategy for the maintenance of cellular, somatic, and systemic homeostasis. Gene-based and pharmacological therapeutic modalities which serve to dysregulate autophagy stimulate or exacerbate various diseases in a multiplicity of studies. Consistently, mutations in autophagy-related genetic processes may cause severe human pathologies. We review research and experimental models in order to establish a linkage between autophagy dysfunction to the pathogenesis of some major human disorders, particularly autoimmune disease.

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The Beneficial and Adverse Effects of Autophagic Response to Caloric Restriction and Fasting

Cited by 25 publications

References 150 publications

Antitumor Effects of an Anthocyanin-Rich Grain Diet in a Mouse Model of Lewis Lung Carcinoma

Antitumor Effects of an Anthocyanin-Rich Grain Diet in a Mouse Model of Lewis Lung Carcinoma

Calorie restriction and calorie-restriction mimetics activate chaperone-mediated autophagy

Potential of Medium to Long-Term Fasting to Trigger an Autoimmune Response Through Hyperaggressive Autophagy

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