The beneficial effect of dietary zinc supplementation on anaemia and immunosuppression in Trypanosoma brucei infected rats

Eze, J. I.; Ayogu, L.C.; Abonyi, Festus Otaka; Eze, Ukamaka U.

doi:10.1016/j.exppara.2015.04.015

Cited by 19 publications

(13 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Zn also plays an important role in hemoglobin synthesis by activating D-aminolevulinic acid (ALA) dehydrogenase, an enzyme essential for the porphobilinogen formation from two ALA molecules. In agreement with previous studies on other animals (El Hendy et al 2001;Sobhanirad and Naserian 2012;Eze et al 2015), results of the present research demonstrated that dietary Zn supplementation could significantly increase the Hb concentration in blood to 5.73 ± 0.46 resulting higher ability of blood to transfer oxygen from the gills to the rest of body. Hb is an iron-containing metalloprotein in the red blood cells of all vertebrates which its synthesis is strongly restricted with the activity of enzymes involved in the Fe metabolism, such as ceruloplasmin, a ferroxidase enzyme associated with possible oxidation of ferrous iron to ferric iron (Lall 2002;Harrison and Arosio 1996).…”

Section: Discussionsupporting

confidence: 82%

Dietary zinc requirement of Siberian sturgeon (Acipenser baerii, Brandt 1869) juveniles, based on the growth performance and blood parameters

et al. 2017

View full text Add to dashboard Cite

This study investigated the effect of dietary Zn levels on growth performance, feed utilization, and hematological parameters of juvenile Siberian sturgeon (Acipenser baerii, Brandt 1869). The five semipurified diets were formulated by adding 0, 5, 10, 20, and 40 mg Zn kg -1 diet in the form of zinc sulfate (ZnSO 4 ) to provide the actual dietary value of 14.7, 20.8, 27.3, 37.7, and 46.4 Zn kg -1 diet, respectively. The results showed that dietary Zn elevating level significantly improved the growth and feed utilization of the fish (p \ 0.05), but not the hepatosomatic index (p [ 0.05). Erythrocyte number, hemoglobin concentration, and hematocrit were increased with raising dietary Zn level (p \ 0.05), whereas a regular trend was not observed in blood indices, including MCV, MCH, and MCHC. A significant increase was also found in the leucocyte number followed by their differential counts, except for eosinophil percentage. The broken line regression model indicated optimal dietary Zn level for growth maximization of fish was estimated to be 29.15 mg Zn kg -1 diet. In spite of well correlation with dietary Zn level, no break point was observed to estimate the juvenile Siberian sturgeon requirement based on the erythrocyte numbers.

show abstract

Section: Discussionsupporting

confidence: 82%

Dietary zinc requirement of Siberian sturgeon (Acipenser baerii, Brandt 1869) juveniles, based on the growth performance and blood parameters

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Many researches have reported the beneficiary effects of supplementing zinc under normal conditions (Overton and Yasui, 2014;Eze et al, 2015). To our knowledge, no previous studies have been conducted to investigate the effects of organic zinc supplementation in the finisher phase on poultry under cyclic heat stress, and so investigating the effects of organic zinc in the finisher phase on broiler chickens under cyclic heat stress conditions may provide a practical tool and novel findings to alleviate the heat stress negative impacts, improve performance, and reduce heat-stressassociated mortality.…”

Section: Introductionmentioning

confidence: 99%

Effects of organic zinc on the performance and gut integrity of broilers under heat stress conditions

et al. 2020

View full text Add to dashboard Cite

Abstract. Heat stress (HS) has negative impacts on farm animals. Many studies have been conducted in order to ameliorate the effects of heat stress in farm animals. The current project investigated the effects of organic zinc supplementation under thermoneutral and heat stress conditions on the production, physiological, and histological parameters in broiler chickens. Three-hundred and sixty chicks in the current project were assigned randomly to six different treatments (n=60 chicks per treatment). The treatments were (1) a basal diet containing 40 mg kg−1 of Zn from an organic source and rearing under thermoneutral (TN) conditions (Ctrl); (2) a diet containing the amount of Zn from the basal diet +50 % of the Zn level (from the basal diet) and rearing under TN conditions (50 TN); (3) a diet containing the amount of Zn from the basal diet +100 % of the Zn level (from the basal diet) and rearing under TN conditions (100 TN); (4) a basal diet containing 40 mg kg−1 of Zn from an organic source and exposure to 3 d of cyclical HS at the age of 35 d (CHS); (5) a diet containing the amount of Zn from the basal diet +50 % of the Zn level (from the basal diet) and exposure to 3 d of cyclical HS at the age of 35 d (50 HS); and (6) a diet containing the amount of Zn from the basal diet +100 % of the Zn level (from the basal diet) and exposure to 3 d of cyclical HS at the age of 35 d (100 HS). Our results indicated that HS has decreased final body weight (fBW), average daily gain (ADG), and feed conversion ratio (FCR) relative to TN chicks. However, organic zinc had little or no effects on the production parameters measures in the current project. Overall, intestinal histological measurements were negatively altered under HS relative to TN chicks. Organic zinc inclusion in the diet had improved villus height in the duodenum and jejunum relative to the Ctrl and CHS chicks. Blood calcium and glucose levels were decreased and increased, respectively, in HS relative to TN chicks. In summary, the results discussed in the current project revealed that the inclusion rates of organic zinc used here had little or no effects on the productive parameters. However, it improved the morphological characteristics of the intestines which might maximized the intestinal efficiency in nutrient absorption under HS conditions.

show abstract

“…There are limited data on significant recovery of anemia in zinc supplemented adult patients . There also have been animal studies suggesting a beneficial effect of this trace mineral on anemia . Consequently, the exact contributory role and degree of zinc in hematological abnormalities in children is not clear.…”

mentioning

confidence: 99%

Zinc deficiency and its predictive capacity for anemia: Unique model in school children

Atasoy

Buğdaycı

2018

Pediatrics International

View full text Add to dashboard Cite

show abstract

The beneficial effect of dietary zinc supplementation on anaemia and immunosuppression in Trypanosoma brucei infected rats

Cited by 19 publications

References 44 publications

Dietary zinc requirement of Siberian sturgeon (Acipenser baerii, Brandt 1869) juveniles, based on the growth performance and blood parameters

Dietary zinc requirement of Siberian sturgeon (Acipenser baerii, Brandt 1869) juveniles, based on the growth performance and blood parameters

Effects of organic zinc on the performance and gut integrity of broilers under heat stress conditions

Zinc deficiency and its predictive capacity for anemia: Unique model in school children

Contact Info

Product

Resources

About