The Beneficial Effect of Human Recombinant Superoxide Dismutase on Acute and Chronic Rejection Events in Recipients of Cadaveric Renal Transplants

Land, W.; Schneeberger, H.; Schleibner, S.; Illner, Wolf–Dieter; Abendroth, D.; Rutili, G.; Arfors, K. E.; Meßmer, K.

doi:10.1097/00007890-199401001-00010

Cited by 370 publications

(213 citation statements)

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“…The return of blood flow causes further organ damage through oxidative stress (OS) and the presence of pro-inflammatory chemokines and cytokines, a process that is referred to as the 'injury hypothesis' (6,7). OS is defined as an overproduction of reactive oxygen species (ROS) that outnumber antioxidant defenses, which is implicated in pathobiological processes associated with the oxidation of biological macromolecules, including proteins, DNA and lipids.…”

Section: Molecular Mechanisms Of I/r Injurymentioning

confidence: 99%

Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury (Review)

Cai

Jia

et al. 2014

Molecular Medicine Reports

117

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Abstract. Dexmedetomidine (DEX), a highly specific α 2 -adrenergic agonist, which exhibits anaesthetic-sparing, analgesia and sympatholytic properties. DEX modulates gene expression, channel activation, transmitter release, inflammatory processes and apoptotic and necrotic cell death. It has also been demonstrated to have protective effects in a variety of animal models of ischemia/reperfusion (I/R) injury, including the intestine, myocardial, renal, lung, cerebral and liver. The broad spectrum of biological activities associated with DEX continues to expand, and its diverse effects suggest that it may offer a novel therapeutic approach for the treatment of human diseases with I/R involvement.

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Section: Molecular Mechanisms Of I/r Injurymentioning

confidence: 99%

Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury (Review)

Cai

Jia

et al. 2014

Molecular Medicine Reports

117

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“…There has been increasing interest in utilization of antioxidants in organ transplantation with clinical trials of some antioxidants (superoxide dismutase, allopurinol) reported [14]. However, results in the clinics as well as in laboratory models have not given conclusive evidence that antioxidants could play a significant role in improving transplant outcome.…”

Section: Introductionmentioning

confidence: 99%

Cold storage sensitizes hepatocytes to oxidative stress injury

1997

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Liver cold storage leads to oxygen free radical production and reperfusion injury. Antioxidants are effective in suppressing reperfusion injury in rat livers when used in the reperfusion medium. However, in clinical liver transplantation their effectiveness is not clear, which may be due to the way they are used (in the recipient). In this study we compare the effectiveness of antioxidants when used in the reperfusion medium versus the cold storage solution in isolated hepatocytes and the isolated perfused liver. Hepatocytes were cold stored in UW solution for 24 h. Oxidative stress, induced by t-butyl hydroperoxide (tBHP), was measured in the presence of one of five different antioxidants -deferoxamine (DFO), dithiothreitol (DTT), trolox, tocopherol, dimethylthiourea (DMTU) -in the reperfusion buffer or UW solution. Efficacy was judged by reduction in membrane damage (LDH release) during rewarming. Also, rat livers were cold stored for 48 h in UW solution ( f antioxidant) and reperfused ( k antioxidants). Efficacy was judged by the effect on enzyme release and bile production. Cold storage of hepatocytes for 24 h sensitized them to oxidative stress. The concentration of tBHP required to induce maximal cell death (80 %-90 % LDH release) was reduced from 1.3 mM (fresh cells) to 0.37 mM (LD-50 values). All antioxidants except DMTU suppressed oxyradical-induced LDH release when used in the reperfusion medium, but only DFO was effective when used in the UW solution. In the isolated perfused liver, DFO, DTT, and trolox were effective and suppressed enzyme release when added to the reperfusion buffer, but none were effective when used in the UW solution. We conclude that cold storage sensitizes liver cells to oxidative stress. The most effective antioxidant was the iron chealator, DFO, which was effective in the reperfusion buffer (isolated perfused liver or hepatocytes) but not in the UW solution when tested in the isolated perfused liver. Suppression of reperfusion injury in liver transplantation could be obtained by antioxidant therapy. However, it is unclear how best to deliver the antioxidants to the site of oxyradical generation.

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“…The study also found that DGF after transplantation could be predicted by the levels of lipid peroxidation markers [22]. Considering the role of lipid peroxidation in the pathobiology of ischemic injury, some researchers have also attempted to use free radical scavengers or antioxidants to minimize post-transplant complications and the results are encouraging [23][24][25]. Although data are still limited, based on these few findings, it could be suggested that regular assessment of lipid peroxidation products in the perfusate of donor kidneys may help to detect those kidneys which have undergone severe oxidative damage.…”

Section: Potential Applications Of Lipid Peroxidation Products In Renmentioning

confidence: 88%

Potential applications of lipid peroxidation products in renal transplantation

Erejuwa¹,

Sulaiman²,

Wahab³

2013

Transplant Technol

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There has been an increased prevalence of end-stage renal disease (ESRD) in the last decades. This can be attributed to high incidence of chronic diseases such as metabolic disorders, diabetes and hypertension. These diseases are often associated with ESRD, which requires regular dialysis and may later necessitate renal transplantation. The increased demand for renal transplantation has resulted in scarcity of donor kidneys leading to receipt of kidneys from extended criteria donors (ECDs) whose kidneys are susceptible to ischemic-injury. The levels of lipid peroxidation products, which are biomarkers of oxidative stress and damage, have been reported to be elevated in ischemic-injury. Therefore, transplantation of kidneys prone to ischemic-injury poses a great danger or high rate of failure in the recipients. The aim of this mini review is to highlight the potential usefulness or application of lipid peroxidation products in screening donor kidneys for renal transplantation. As a result of machine perfusion (MP), it is now possible to determine certain biomarkers such as lipid peroxidation products in the perfusate which reveal kidneys that have undergone severe ischemic and/or oxidative damage. This will help in screening or identification of kidneys that are unfit for transplantation. Besides, lipid peroxidation products can also be used to monitor or evaluate patient's post-transplant recovery. Thus, measurement of lipid peroxidation products may help to reduce post-transplant failure and improve the quality of life of recipients.

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The Beneficial Effect of Human Recombinant Superoxide Dismutase on Acute and Chronic Rejection Events in Recipients of Cadaveric Renal Transplants

Cited by 370 publications

References 0 publications

Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury (Review)

Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury (Review)

Cold storage sensitizes hepatocytes to oxidative stress injury

Potential applications of lipid peroxidation products in renal transplantation

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