The Beneficial Effect of Salicornia herbacea Extract and Isorhamnetin-3-O-Glucoside on Obesity

Abstract

Salicornia herbacea is a halophyte indigenous to marine coastal areas and salt fields and has been used as a traditional remedy for diarrhea, abdominal pain, constipation, and indigestion. Its component isorhamnetin-3-O-glucoside (IR3G) may have antioxidant, anti-inflammatory, and anti-adipogenic properties. In the present study, we aimed to investigate the anti-obesity effect of S. herbacea extract and IR3G on mouse 3T3-L1 adipocytes and db/db obesity mice. S. herbacea extract and IR3G inhibited lipase in a concentration-dependent manner. Oil Red O staining disclosed that S. herbacea extract and IR3G significantly suppressed lipid accumulation and adipogenesis and also inhibited the expression of the C/EBPα in the 3T3-L1 adipocytes. In experiments using db/db mice, administering of S. herbacea extract limited body weight gain and significantly reduced feed efficiency and adipose tissue weight. Moreover, analyzing blood triglycerides, total cholesterol, high-density lipoprotein, and low-density lipoprotein, it was confirmed that LDL was significantly decreased and total cholesterol slightly reduced by S. herbacea extract. However, there was no significant change by S. herbacea extract in the changes in blood levels of leptin and adiponectin. Taken together, these results suggest that S. herbacea extract and IR3G inhibit adipogenesis by suppressing the pro-adipogenic transcription factors in 3T3-L1 preadipocytes and prevent obesity by regulating the blood lipid profile as well as the weight of adipose tissue.

Assessing Sarcocornia as a Salt Substitute: Effects on Lipid Profile and Gelatinase Activity

“…In this context, Lee Ji Hwan et al highlighted that the administration of Salicornia extract in db/db rats allows for an improvement in obesity by inhibiting adipocyte differentiation. Additionally, a concomitant decrease in LDL-c and triglyceride levels was observed, supporting the idea that there is an improvement in metabolism and dyslipidemia [56].…”

In vivo Effects of Salicornia herbacea and Calystegia soldanella Extracts for Memory Improvement

“…Notably, tungtungmadic acid has been found to protect plasmid DNA from strand breakage induced by Fe 3+ -nitrilotriacetic acid-hydrogen peroxide [ 32 ]. Isorhamnetin 3-O-glucoside has shown inhibitory effects on adipogenesis by suppressing pro-adipogenic transcription factors in 3T3-L1 preadipocytes, potentially preventing obesity by regulating blood lipid profiles and adipose tissue weight [ 33 ]. Kaempferol-like compounds have been extracted from C. soldanella .…”

The Bioactivity and Phytochemicals of Muscari comosum (Leopoldia comosa), a Plant of Multiple Pharmacological Activities

“…The worldwide occurrence of overweight and obesity is worryingly growing and also leading to several other serious public health concerns [ 47 ]. As with diabetes, the natural compounds are believed to have the potential to be developed against obesity [ 48 , 49 ]. The accumulation of excessive fat and its inappropriate storage is considered as obesity; hence, fat and the dysregulation of its metabolism can be considered as the primary factors responsible for obesity in the population.…”