The Beneficial Effect of Spinal Cord Stimulation in a Patient With Severe Cerebral Ischemia and Upper Extremity Ischemic Pain

Andrés, José De; Tatay, J; Revert, Amparo; Valía, Juan Carlos; Villanueva, V.

doi:10.1111/j.1533-2500.2007.00121.x

Cited by 10 publications

(4 citation statements)

References 43 publications

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“…Only in five cases the SCS was implanted in patients previously revascularised, presenting a much compromised distal arterial bed and one SCS was positioned in the cervical peridural space for the treatment of steal syndrome in a haemodialysis patient. Application of SCS in the cervical space has been previously reported in literature for the treatment of different diseases . Results of our study were very encouraging: group A showed a healing rate of 100%, group B of 78%, group C of 57% and group D of 88%.…”

Section: Discussionsupporting

confidence: 63%

Spinal cord stimulation to achieve wound healing in a primary lower limb critical ischaemia referral centre

Caridi

Massara

David

et al. 2014

International Wound Journal

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Critical lower limb ischaemia is a diffuse pathology that could cause claudication, severe ischaemic pain and tissue loss. The common treatment includes modification of risk factors, pharmacological therapy and endovascular or surgical revascularisation of the lower limb to restore a pulsatile flow distally. Spinal cord stimulator is seen as a valid alternative in patients unsuitable for revascularisation after endovascular or surgical revascularisation failure and as adjuvant therapy in the presence of a functioning bypass in patients with extensive tissue loss and gangrene presenting a slow and difficult wound healing. We report our experience on spinal cord stimulation (SCS) indication and implantation in patients with critical lower limb ischaemia, at a high-volume centre for the treatment of peripheral arterial disease.

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Section: Discussionsupporting

confidence: 63%

Spinal cord stimulation to achieve wound healing in a primary lower limb critical ischaemia referral centre

Caridi

Massara

David

et al. 2014

International Wound Journal

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“…According to the previous experiences of Mazzone et al [19,20] , the evidence of redistribution of CBF rather than a clear increase was shown in such patients. More recently, De Andrés et al [53] published a case harboring both severe cerebral ischemia and upper extremity ischemic pain, successfully treated with cervical SCS. A large series has recently been published by Liu et al [54] who observed an increase of cerebral blood perfusion and catecholamine in CSF after SCS, suggesting that SCS increases cerebral blood perfusion, attenuates oxidative stress and increases biogenic amines in comatose patients.…”

Section: Clinical Trials On Hypoperfusion Syndromes In Humansmentioning

confidence: 99%

Spinal Cord Stimulation and Cerebral Hemodynamics: Updated Mechanism and Therapeutic Implications

Visocchi

Pepa

Esposito

et al. 2011

Stereotact Funct Neurosurg

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The effects of spinal cord stimulation (SCS) on cerebral blood flow (CBF) are well known based on experimental investigations, and its vasodilator effect on peripheral arteries is widely used in clinical settings in the treatment of peripheral vascular disease. Since Hosobuchi’s [Appl Neurophysiol 1985;48:372–376] first observations on the effects of SCS on CBF were published 22 years ago, many advances have been made in understanding SCS-mediated effects on CBF. This paper reviews the main laboratory observations and analyzes the most significant neurophysiological theories on the SCS-mediated effect on CBF. Most significant experimental data have been discussed, with specific reference to possible mechanisms such as ‘functional reversible sympathectomy’, cerebral infarction and related ischemic edema, hemodynamic deterioration in experimental combined ischemic-traumatic brain injury and cerebral vasospasm. The authors revised the published experiences in humans with hypoperfusion syndromes and ‘adjuvant’ locoregional CBF increase in chemotherapy of brain tumors. SCS represents a new perspective in challenging neurosurgical clinical fields such as cerebral ischemia and vasospasm, and seems promising as a new trend of functional neurosurgery in cerebrovascular diseases.

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“…However, there is not yet an ultimate scientific explanation; moreover, a clear understanding of the mechanisms elicited by SCS is still lacking [4,53,68]. Different hypotheses have been reported in the literature so far.…”

Section: Discussionmentioning

confidence: 99%

“…SCS has been shown to augment CBF and speculated to protect the brain from focal ischemia in a large series of experiments, both on animals and on humans [47,48,49,50,51,52,53], and has been proposed for the treatment of several cerebral low-perfusion syndromes [54,55,56,57,58,59,60,61,62,63,64,65,66,67]. However, there is not yet an ultimate scientific explanation; moreover, a clear understanding of the mechanisms elicited by SCS is still lacking [4,53,68].…”

Section: Discussionmentioning

confidence: 99%

Neuromodulation of Vegetative State through Spinal Cord Stimulation: Where Are We Now and Where Are We Going?

Pepa

Fukaya

Rocca

et al. 2013

Stereotact Funct Neurosurg

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Background: Vegetative state (VS) is a complex condition that represents a challenging frontier for medicine and neuroscience research. Nowadays there is no scientifically validated treatment for VS patients, and their chronic long-term assistance is very demanding for healthcare systems worldwide. Objectives: The present paper is a systematic review of the role of spinal cord stimulation (SCS) as a treatment of patients with VS. Methods: Published literature on this topic was analyzed systematically. Clinical and epidemiological characteristics of VS, present therapeutic options and social costs of VS were also evaluated. Results: Only 10 papers have been published since 1988, and overall 308 VS patients have been treated with SCS worldwide; 51.6% displayed a clinical improvement and an amelioration of the environmental interaction. These effects are probably mediated by the stimulation of the reticular formation-thalamus-cortex pathway and by cerebral blood flow augmentation induced by SCS. Conclusions: The experience on this topic is still very limited, and on this basis it is still hard to make any rigorous assessment. However, the most recent experiments represent significant progress in the research on this topic and display SCS as a possible therapeutic tool in the treatment of VS.

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The Beneficial Effect of Spinal Cord Stimulation in a Patient With Severe Cerebral Ischemia and Upper Extremity Ischemic Pain

Cited by 10 publications

References 43 publications

Spinal cord stimulation to achieve wound healing in a primary lower limb critical ischaemia referral centre

Spinal cord stimulation to achieve wound healing in a primary lower limb critical ischaemia referral centre

Spinal Cord Stimulation and Cerebral Hemodynamics: Updated Mechanism and Therapeutic Implications

Neuromodulation of Vegetative State through Spinal Cord Stimulation: Where Are We Now and Where Are We Going?

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