The Beneficial Effects of Two Polysaccharide Fractions from Sargassum fusiform against Diabetes Mellitus Accompanied by Dyslipidemia in Rats and Their Underlying Mechanisms

Jia, Rui-Bo; Wu, Juan; Luo, Da; Lin, Lianzhu; Chen, Chong; Xiao, Chuqiao; Zhao, Ming

doi:10.3390/foods11101416

Cited by 9 publications

(6 citation statements)

References 39 publications

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“…Many studies found that long-term drug therapies for patients with T2D would result in various side effects and generate drug resistance, while natural plant extracts have been demonstrated as alternative therapeutic agents or supplements to treat T2D by alleviating oxidative damage and hyperglycemia (34,35). Currently, the exploration of novel antidiabetic drugs or dietary supplements from natural products is a hotspot in the research field of T2D.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic and H2O2-induced oxidative injury protective effects and the phytochemical profiles of the ethyl acetate fraction from Radix Paeoniae Alba

Zhang

Peng²,

Wang³

et al. 2023

Front. Nutr.

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Radix Paeonia Alba (RPA) is often used as food and medicine. This study aimed to enrich and identify the antioxidant and hypoglycemic bioactive compounds from RPA. The results indicated that the ethyl acetate fraction (EAF) showed the highest total phenolic content, DPPH, ABTS+ scavenging ability, and α-glucosidase inhibition ability (IC50 = 7.27 μg/ml). The EAF could alleviate H2O2-induced oxidative stress in HepG2 cells by decreasing the MDA and ROS levels, improving cell apoptosis, increasing the enzyme activity of GPX-Px, CAT, SOD, Na+/K+-ATP, and Ca2+/Mg2+-ATP, and stimulating T-AOC expression, which also enhanced the glucose uptake of insulin-resistant HepG2 cells. In addition, the EAF significantly reduced the fasting blood glucose level and improved glucose tolerance in diabetic mice. An HPLC-QTOF-MS/MS analysis displayed that procyanidin, digallic acid isomer, methyl gallate, tetragalloylglucose isomer, dimethyl gallic acid, and paeoniflorin were the major compounds in the EAF. These findings are meaningful for the application of the EAF in the medicinal or food industry to prevent and treat oxidative stress and diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%

Hypoglycemic and H2O2-induced oxidative injury protective effects and the phytochemical profiles of the ethyl acetate fraction from Radix Paeoniae Alba

Zhang

Peng²,

Wang³

et al. 2023

Front. Nutr.

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“…Akt signaling was a crucial modulator in the cell growth, and the phosphorylation of the Akt could lead to cell proliferation [ 30 , 31 ]. GSK-3 β was confirmed to be involved in glycogen synthesis, which could decrease blood glucose [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Xiaotangzhike Pill Attenuates the Progression of Diabetes In Vivo through the Mediation of the Akt/GSK-3β Axis

Yang

Wang

Fan

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Diabetes seriously threatens the health of people. Traditional Chinese medicine has been proven to inhibit the progression of diabetes. Meanwhile, the Xiaotangzhike pill (XTZK) was known to alleviate the symptom of diabetes. Thus, this research decided to investigate the mechanism underlying the impact of XTZK in diabetes remains unexplored. Methods. To assess the impact of XTZK in diabetes, in vivo model of diabetes was constructed. The contents of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) in the rats were tested by the commercial kits. In addition, Masson and hematoxylin and eosin (H&E) staining were applied for assessing the histological changes and fibrosis in the rats, respectively. Furthermore, a western blot was applied to assess the protein levels. Results. Streptozotocin (STZ) significantly increased the levels of area under the curve (AUC), TG, TC, LDL-C, and decreased the contents of HDL-C in rats, while these phenomena were partially reversed by XTZK. In addition, STZ notably induced inflammatory infiltration and fibrosis in the liver tissues of rats, which was greatly restored by XTZK. The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde (MDA) in the serum of rats were notably upregulated by STZ, while the effect of STZ was markedly abolished by XTZK. Meanwhile, STZ-caused the upregulation of p-Smad2 and α-SMA in rats was restored by XTZK. Furthermore, XTZK notably inhibited the progression of Qi and Yin deficiency syndrome in diabetes through the mediation of the Akt/GSK-3β axis. Conclusion. The Xiaotangzhike pill attenuates the progression of diabetes through the mediation of the Akt/GSK-3β axis. Hence, our study might supply a novel insight into discovering new strategies against diabetes.

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“…Cao et al showed that both the polysaccharide fractions SPP-1 and PSP-1 from S. pallidum exhibited significant hypoglycemic activity in vitro and could effectively inhibit α-amylase and α-glucosidase activities [ 44 , 47 ]; similar results were proved in other studies [ 45 , 46 ]. SFP-2, SFF and SFP-7-40 obtained from S. fusiform effectively alleviate DM through different mechanisms in vivo [ 51 , 52 , 57 , 59 , 62 ]. The fractions, LMWF, UP4 and UPP, extracted from U. pinnatifida have significant hypoglycemic effects in vivo [ 38 , 56 , 60 ].…”

Section: Marine Polysaccharides With Hypoglycemic Activitymentioning

confidence: 99%

“…It was further verified that Lactobacillus , Weissella , Romboutsia , Dubosiella and Turicibacter dominate the microenvironment of the intestinal microbiota administered via ULP and contribute to ameliorate the harmful effects of diabetes on the organism [ 64 ]. SFP-2 extracted from S. fusiform can promote the growth of Muribaculaceae_norank , Akkermansia , Bifidobacterium and Lactobacillus in the guts of diabetic rats and increase the abundance of intestinal microflora [ 51 ]. Other researchers have found similar results with FU extracted from different Sargassum species because the higher ratio of fucose and galactose in them favors colon microbiota fermentation, changes the abundance of probiotics and reduces the pathogenic bacteria and promotes the intestinal microflora of diabetic rats at the normal level [ 52 , 59 ].…”

Section: Hypoglycemic Mechanisms Of Marine Fucosyl-polysaccharidesmentioning

confidence: 99%

Potential Application of Marine Fucosyl-Polysaccharides in Regulating Blood Glucose and Hyperglycemic Complications

Tang

Xiao

Cai

et al. 2023

Foods

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Diabetes mellitus (DM) has become the world’s third major disease after tumors and cardiovascular disease. With the exploitation of marine biological resources, the efficacy of using polysaccharides isolated from marine organisms in blood glucose regulation has received widespread attention. Some marine polysaccharides can reduce blood glucose by inhibiting digestive enzyme activity, eliminating insulin resistance, and regulating gut microbiota. These polysaccharides are mainly fucose-containing sulphated polysaccharides from algae and sea cucumbers. It follows that the hypoglycemic activity of marine fucosyl-polysaccharides is closely related to their structure, such as their sulfate group, monosaccharide composition, molecular weight and glycosidic bond type. However, the structure of marine fucosyl-polysaccharides and the mechanism of their hypoglycemic activity are not yet clear. Therefore, this review comprehensively covers the effects of marine fucosyl-polysaccharides sources, mechanisms and the structure–activity relationship on hypoglycemic activity. Moreover, the potential regulatory effects of fucosyl-polysaccharides on vascular complications caused by hyperglycemia are also summarized in this review. This review provides rationales for the activity study of marine fucosyl-polysaccharides and new insights into the high-value utilization of marine biological resources.

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The Beneficial Effects of Two Polysaccharide Fractions from Sargassum fusiform against Diabetes Mellitus Accompanied by Dyslipidemia in Rats and Their Underlying Mechanisms

Cited by 9 publications

References 39 publications

Hypoglycemic and H2O2-induced oxidative injury protective effects and the phytochemical profiles of the ethyl acetate fraction from Radix Paeoniae Alba

Hypoglycemic and H2O2-induced oxidative injury protective effects and the phytochemical profiles of the ethyl acetate fraction from Radix Paeoniae Alba

Xiaotangzhike Pill Attenuates the Progression of Diabetes In Vivo through the Mediation of the Akt/GSK-3β Axis

Potential Application of Marine Fucosyl-Polysaccharides in Regulating Blood Glucose and Hyperglycemic Complications

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