The Beneficial Therapy with Colchicine for Atherosclerosis via Anti-inflammation and Decrease in Hypertriglyceridemia

Spartalis, Μichael; Spartalis, Eleftherios; Tzatzaki, Eleni; Tsilimigras, Diamantis I.; Moris, Demetrios; Kontogiannis, Christos; Kaminiotis, Vaios Vasileios; Paschou, Stavroula Α.; Chatzidou, Sofia; Siasos, Gerasimos; Voudris, Vassilis; Iliopoulos, Dimitrios

doi:10.2174/1871525717666181211110332

Cited by 18 publications

(7 citation statements)

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“…A 2018 narrative review showed that colchicine has beneficial effects on atherosclerosis with plaque stabilisation, reduction of cardiovascular damage, and reduction in recurrence of acute coronary syndromes. 90 Colchicine might also have protective effects in stable coronary artery disease. 91 Two retrospective cohort studies in patients with gout showed a lower incidence of combined cardiovascular outcomes in patients treated with colchicine.…”

Section: Cardiovascular Effects Of Drug Treatmentmentioning

confidence: 99%

Cardiovascular risk in inflammatory arthritis: rheumatoid arthritis and gout

Hansildaar

Vedder

Baniaamam

et al. 2021

The Lancet Rheumatology

159

111

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The increased risk of cardiovascular morbidity and mortality in rheumatoid arthritis and gout has been increasingly acknowledged in past decades, with accumulating evidence that gout, just as with rheumatoid arthritis, is an independent cardiovascular risk factor. Although both diseases have a completely different pathogenesis, the underlying pathophysiological mechanisms in systemic inflammation overlap to some extent. Following the recognition that systemic inflammation has an important causative role in cardiovascular disease, anti-inflammatory therapy in both conditions and urate-lowering therapies in gout are expected to lower the cardiovascular burden of patients. Unfortunately, much of the existing data showing that urate-lowering therapy has consistent beneficial effects on cardiovascular outcomes in patients with gout are of low quality and contradictory. We will discuss the latest evidence in this respect. Cardiovascular disease risk management for patients with rheumatoid arthritis and gout is essential. Clinical guidelines and implementation of cardiovascular risk management in daily clinical practice, as well as unmet needs and areas for further investigation, will be discussed.

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Section: Cardiovascular Effects Of Drug Treatmentmentioning

confidence: 99%

Cardiovascular risk in inflammatory arthritis: rheumatoid arthritis and gout

Hansildaar

Vedder

Baniaamam

et al. 2021

The Lancet Rheumatology

159

111

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“…This means that the entire system of interactions and reciprocal feedbacks during atherosclerotic plaque destabilization is very complex, and simple approaches (i.e., blocking factors that are considered to be proinflammatory) tend to be insufficient. For this reason, more general anti-inflammatory approaches are also used, for instance, colchicine, which has presented complex effects by inhibiting critical inflammatory signaling networks (inflammasome, proinflammatory cytokines, and adhesion molecules) [ 50 , 51 ]. Moreover, inflammatory mediators such as interleukins are under the control of transcription factors.…”

Section: Approaches Directed At Specific Molecular Pathwaysmentioning

confidence: 99%

Different Approaches in Therapy Aiming to Stabilize an Unstable Atherosclerotic Plaque

Kowara

Cudnoch‐Jędrzejewska

2021

IJMS

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Atherosclerotic plaque vulnerability is a vital clinical problem as vulnerable plaques tend to rupture, which results in atherosclerosis complications—myocardial infarctions and subsequent cardiovascular deaths. Therefore, methods aiming to stabilize such plaques are in great demand. In this brief review, the idea of atherosclerotic plaque stabilization and five main approaches—towards the regulation of metabolism, macrophages and cellular death, inflammation, reactive oxygen species, and extracellular matrix remodeling have been presented. Moreover, apart from classical approaches (targeted at the general mechanisms of plaque destabilization), there are also alternative approaches targeted either at certain plaques which have just become vulnerable or targeted at the minimization of the consequences of atherosclerotic plaque erosion or rupture. These alternative approaches have also been briefly mentioned in this review.

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“…Second, at the recommended doses, colchicine offers minimal or no impact on platelets, hence, making it a preferable partner to cardiovascular regimens that may include multiple of drugs which increase the risk of bleeding. Moreover, colchicine is less expensive than newer agents and biologics and is readily available throughout the world (Fiolet, Nidorf, Mosterd, & Cornel, 2019;Lin et al, 2018;Spartalis et al, 2018). In patients with CHD, low dose of colchicine in conjunction with statins has shown efficacy in reducing coronary atherosclerotic plaque (Thompson & Nidorf, 2018).…”

Section: Colchicinementioning

confidence: 99%

Pathophysiology of atherosclerosis: Association of risk factors and treatment strategies using plant‐based bioactive compounds

et al. 2020

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Under physiological conditions, endothelial cells act as protective barrier which prevents direct contact of blood with circulating factors via production of tissue plasminogen activator. Risk factors of metabolic disorders are responsible to induce endothelial dysfunction and may consequently lead to prognosis of atherosclerosis. This article summarizes the process of atherosclerosis which involves number of sequences including formation and interaction of AGE-RAGE, activation of polyol pathway, protein kinase C, and hexosamine-mediated pathway. All these mechanisms can lead to the development of oxidative stress which may further aggravate condition. Different pharmacological interventions are being used to treat atherosclerosis, however, these might be associated with mild to severe side effects. Therefore, plantbased bioactive compounds having potential to combat and prevent atherosclerosis in diabetic patients are attaining recent focus. By understanding process of development and mechanisms involved in atherosclerotic plaque formation, these bioactive compounds can be better option for future therapeutic interventions for atherosclerosis treatment.

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The Beneficial Therapy with Colchicine for Atherosclerosis via Anti-inflammation and Decrease in Hypertriglyceridemia

Cited by 18 publications

References 0 publications

Cardiovascular risk in inflammatory arthritis: rheumatoid arthritis and gout

Cardiovascular risk in inflammatory arthritis: rheumatoid arthritis and gout

Different Approaches in Therapy Aiming to Stabilize an Unstable Atherosclerotic Plaque

Pathophysiology of atherosclerosis: Association of risk factors and treatment strategies using plant‐based bioactive compounds

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