The Benefit Of Locally Ablative Treatment In Lung Metastasis From Colorectal Cancer

Abstract

ALBI grades better stratified OS than CP category (Table 1) as CP B7 patients had worse 1-yr OS than CP B8-9, while increasing ALBI grade clearly correlated with decreasing OS (log-rank p<.0001). AUC estimates for ALBI and CP were 74.2% and 65.6%, respectively (p Z .34). Within the subgroup of patients with CP B or C liver disease, ALBI 2 and 3 effectively stratified 1-year OS (62% and 17%, log-rank p Z .004). As seen in Table, ALBI stratified 1-yr risk of liver function decline, with ALBI 1 and 2 grades showing similar rates of decompensation but ALBI 3 with clearly higher rates. Within the CP B or C subgroup, ALBI 2 and 3 effectively stratified risk of 4-month liver function decline (12% vs. 69%, p Z .002), but lost significance comparing risk of 1-yr liver function decline (53% vs. 77%, p Z .19). Conclusion: In a cohort of HCC patients treated with definitive RT, ALBI grade may identify a subgroup of patients with CP B/C liver disease who are safer radiotherapy candidates.