The Benefits of Exercise and Metabolic Interventions for the Prevention and Early Treatment of Alzheimer's Disease

Maliszewska-Cyna, Ewelina; Lynch, Madelaine; Oore, Jonathan; Nagy, Paul Michael; Aubert, Isabelle

doi:10.2174/1567205013666160819125400

Cited by 67 publications

(23 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Improvements in brain function, cognition [7,8], and even brain structural volumes have been noticed with aerobic activity interventions [9]. PA also protects against the development of neurodegenerative diseases, including Alzheimer's disease [10], and has been shown to improve cognitive function in Alzheimer's patients [11]. There is also evidence of a relationship between PA and positive effects on mood and anxiety, including decreases in the risk of incident depression [12] and improved symptoms in persons with pre-existing depression or anxiety [13][14][15][16][17].…”

Section: Pa and Healthmentioning

confidence: 99%

Physical activity, visual impairment, and eye disease

Ong

Crowston

Loprinzi

et al. 2018

Eye

102

View full text Add to dashboard Cite

Numerous studies have demonstrated physical activity is a strong factor in overall health and well-being, and a growing body of literature, reviewed herein, suggests that several eye conditions, including glaucoma, age-related macular degeneration, and diabetic retinopathy, are associated with lower activity levels. Likewise, physical activity levels are lower in persons with worse vision. Research in this area has utilized both self-reported physical activity measures as well as objective measures of activity (i.e., accelerometers), each of which have their own strengths and limitations. Putative mechanisms explaining the association of various eye conditions with physical activity are discussed. It is possible that activity restriction occurs as a downstream consequence of eye disease/visual impairment, that activity restriction causes eye disease/visual impairment, or that causality is bidirectional; evidence supporting each of these theories is put forth. An improved understanding of the relationship between physical activity and eye disease will highlight potential secondary health risks resulting from eye disease, and can help determine whether activity might serve as a readily available preventative measure to prevent specific eye conditions.

show abstract

Section: Pa and Healthmentioning

confidence: 99%

Physical activity, visual impairment, and eye disease

Ong

Crowston

Loprinzi

et al. 2018

Eye

102

View full text Add to dashboard Cite

show abstract

“…Lower risks of AD have been reported in cultures with a traditional high-fiber cuisine, such as those in Sub-Saharan Africa, as well individuals adhering to the Mediterranean, or Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) diets [ 65–68 ]. Exercise contributes to vascular health, which has a positive impact on BBB in aging [ 69 ]. Lactate, created during exercise, is another fuel that can traverse the BBB via monocarboxylate transporters that are independent of GLUT1 and the BBB’s age-related changes [ 70, 71 ].…”

Section: Epidemiological Considerationsmentioning

confidence: 99%

Alzheimer’s Disease as the Product of a Progressive Energy Deficiency Syndrome in the Central Nervous System: The Neuroenergetic Hypothesis

Blonz

2017

JAD

View full text Add to dashboard Cite

The decreased availability of metabolizable energy resources in the central nervous system is hypothesized to be a key factor in the pathogenesis of Alzheimer’s disease. More specifically, the age-related decline in the ability of glucose to cross the blood-brain barrier creates a metabolic stress that shifts the normal, benign processing of amyloid-β protein precursor toward pathways associated with the production of amyloid-β plaques and tau-containing neurofibrillary tangles that are characteristic of the disease. The neuroenergetic hypothesis provides insight into the etiology of Alzheimer’s disease and illuminates new approaches for diagnosis, monitoring, and treatment.

show abstract

“…It is possible for at risk individuals to prevent or delay AD by addressing these factors. There has been abundant and compelling evidence showing its feasibility (Love and Miners, 2016 ; Maliszewska-Cyna et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

The Dose-Dependent Effects of Vascular Risk Factors on Dynamic Compensatory Neural Processes in Mild Cognitive Impairment

Chen

et al. 2018

Front. Aging Neurosci.

View full text Add to dashboard Cite

Background/Objectives: Mild cognitive impairment (MCI) has been associated with risk for Alzheimer's Disease (AD). Previous investigations have suggested that vascular risk factors (VRFs) were associated with cognitive decline and AD pathogenesis, and the intervention of VRFs may be a possible way to prevent dementia. However, in MCI, little is known about the potential impacts of VRFs on neural networks and their neural substrates, which may be a neuroimaging biomarker of the disease progression.Methods: 128 elderly Han Chinese participants (67 MCI subjects and 61 matched normal elderly) with or without VRFs (hypertension, diabetes mellitus, hypercholesterolemia, smoking and alcohol drinking) underwent the resting-state functional magnetic resonance imaging (fMRI) and neuropsychological tests. We obtained the default mode network (DMN) to identify alterations in MCI with the varying number of the VRF and analyzed the significant correlation with behavioral performance.Results: The effects of VRF on the DMN were primarily in bilateral dorsolateral prefrontal cortex (DLPFC) (i.e., middle frontal gyrus). Normal elderly showed the gradually increased functional activity of DLPFC, while a fluctuant activation of DLPFC was displayed in MCI with the growing number of the VRF. Interestingly, the left DLPFC further displayed significantly dynamic correlation with executive function as the variation of VRF loading. Initial level of compensation was observed in normal aging and none-vascular risk factor (NVRF) MCI, while these compensatory neural processes were suppressed in One-VRF MCI and were subsequently re-aroused in Over-One-VRF MCI.Conclusions: These findings suggested that the dose-dependent effects of VRF on DLPFC were highlighted in MCI, and the dynamic compensatory neural processes that fluctuated along with variations of VRF loading could be key role in the progression of MCI.

show abstract

The Benefits of Exercise and Metabolic Interventions for the Prevention and Early Treatment of Alzheimer's Disease

Cited by 67 publications

References 0 publications

Physical activity, visual impairment, and eye disease

Physical activity, visual impairment, and eye disease

Alzheimer’s Disease as the Product of a Progressive Energy Deficiency Syndrome in the Central Nervous System: The Neuroenergetic Hypothesis

The Dose-Dependent Effects of Vascular Risk Factors on Dynamic Compensatory Neural Processes in Mild Cognitive Impairment

Contact Info

Product

Resources

About