The benefits of photoacoustics for the monitoring of drug stability and penetration through tissue-mimicking membranes

Rochowski, Paweł; Niedziałkowski, Paweł; Pogorzelski, S.

doi:10.1016/j.ijpharm.2020.119233

Cited by 11 publications

(1 citation statement)

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“…In order to roughly estimate the chemical similarity between the paints being a mixture of constituents, the photoacoustic spectra (PAS) of the paint-covered metal surfaces were determined with a closed-type photoacoustic cell system, as described elsewhere [ 28 ]. Unlike the standard spectroscopic methods, photoacoustic-based modalities allow us to probe spectral characteristics of opaque materials without any need for special sample modifications.…”

Section: Methodsmentioning

confidence: 99%

Wettability of Metal Surfaces Affected by Paint Layer Covering

et al. 2022

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The aim of the work was to quantify the surface wettability of metallic (Fe, Al, Cu, brass) surfaces covered with sprayed paints. Wettability was determined using the contact angle hysteresis approach, where dynamic contact angles (advancing ΘA and receding ΘR) were identified with the inclined plate method. The equilibrium, ΘY, contact angle hysteresis, CAH = ΘA − ΘR, film pressure, Π, surface free energy, γSV, works of adhesion, WA, and spreading, WS, were considered. Hydrophobic water/solid interactions were exhibited for the treated surfaces with the dispersive term contribution to γSV equal to (0.66–0.69). The registered 3D surface roughness profiles allowed the surface roughness and surface heterogeneity effect on wettability to be discussed. The clean metallic surfaces turned out to be of a hydrophilic nature (ΘY < 90°) with high γSV, heterogeneous, and rough with a large CAH. The surface covering demonstrated the parameters’ evolution, ΘA↑, ΘR↑, γSV↓, WA↓, and WS↓, corresponding to the surface hydrophobization and exhibiting base substratum-specific signatures. The dimensionless roughness fluctuation coefficient, η, was linearly correlated to CAH. The CAH methodology based on the three measurable quantities, ΘA, ΘR, and liquid surface tension, γLV, can be a useful tool in surface-mediated process studies, such as lubrication, liquid coating, and thermoflow.

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Section: Methodsmentioning

confidence: 99%