The Benefits of Sacubitril-Valsartan in Low Ejection Fraction Heart Failure

Aşkın, Lütfü; Tanrıverdi, Okan

doi:10.47493/abantmedj.1182158

Cited by 6 publications

(5 citation statements)

References 60 publications

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“…Also, several mechanisms are considered for ACEI/ARBs, and some BBs, including carvedilol, inhibit erythropoiesis [ 28 – 30 ]. However, recent studies reported that sacubitril/valsartan (Neprilysin/Angiotensin Receptor Inhibitor) reduces anemia in patients with CRS [ 31 , 32 ]. MRAs may induce erythropoiesis by down-regulating hepcidin.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of, association with, severity of, and prognostic role of serum hemoglobin level in acutely decompensated heart failure patients

Omoomi,

Heidarpour,

Rabanipour

et al. 2023

BMC Cardiovasc Disord

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Background The role of hemoglobin (Hb) level in the short-term prognosis of patients with acute decompensated heart failure (ADHF) remains a matter of debate. We aimed to declare the prevalence of, association with, severity of, and prognostic role of SHL with ADHF. Methods Using the data from the Persian Registry Of Cardiovascular Disease/ Heart Failure (PROVE-HF) study, we assessed the association between anemia and polycythemia (Hb < 13 g/dLit, > 16.5 g/dLit in males and < 12 g/dLit, and > 16 g/dLit in females, respectively) and short-term mortality using Cox proportional hazard modeling, with adjustment of clinically relevant variables. Results Of 3652 ADHF patients, anemia was seen in 1673 patients (48.40%). The prevalence of mild, moderate, and severe anemia was 42.33% (n = 1546), 3.23% (n = 118), and 0.24% (n = 9), respectively. Also, 422 patients (11.55%) had polycythemia. Compared to non-anemic patients, anemic patients were mainly male, older, and were more likely to have diabetes mellitus (DM), renal dysfunction, hypertension (HTN), and thyroid disease. Significant predictors of short-term mortality were lower systolic and diastolic blood pressure, lower Hb level, and higher blood urea nitrogen (BUN). Anemic patients had higher all-cause mortality [adjusted hazard ratio (aHR) 1.213, 95% confidence interval [CI] 1.054–1.396]. Moderate anemia increased mortality by approximately 80% in males (aHR 1.793, 95% CI 1.308–2.458) and females (aHR 1.790, 95% CI 1.312–2.442), respectively. Polycythemia had no association with short-term mortality in both genders (P-value > 0.05). Conclusions This study revealed that anemia is an adverse prognostic factor for short-term mortality in ADHF patients, with higher mortality in moderately anemic patients.

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Section: Discussionmentioning

confidence: 99%

Prevalence of, association with, severity of, and prognostic role of serum hemoglobin level in acutely decompensated heart failure patients

Omoomi,

Heidarpour,

Rabanipour

et al. 2023

BMC Cardiovasc Disord

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“…After ablation of the LBB, mechanical activity in the left ventricle is no longer synchronized, and sustained rapid atrial pacing might lead to left ventricular enlargement and a decrease in left ventricular function. In comparison to other methods used to establish animal models of heart failure, the approach used in this study may be more representative of the pathophysiological mechanisms of heart failure in patients with dilated cardiomyopathy [13,14].…”

Section: Discussionmentioning

confidence: 99%

Left Bundle Branch Ablation Guided by a Three-Dimensional Mapping System: A Novel Method for Establishing a Heart Failure Animal Model

He,

Jin,

et al. 2023

CVIA

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Objective: Few studies have been conducted to establish animal models of left bundle branch block by using three-dimensional mapping systems. This research was aimed at creating a canine left bundle branch block model by using a three-dimensional mapping system. Materials and Methods: We used a three-dimensional mapping system to map and ablate the left bundle branch in beagles. Results: Ten canines underwent radiofrequency ablation, among which left bundle branch block was successfully established in eight, one experienced ventricular fibrillation, and one developed third-degree atrioventricular block. The maximum HV interval measured within the left ventricle was 29.00 ± 2.93 ms, and the LBP-V interval at the ablation site was 20.63 ± 2.77 ms. The LBP-V interval at the ablation target was 71.08% of the maximum HV interval. Conclusion: This three-dimensional mapping system is a reliable and effective guide for ablation of the left bundle branch in dogs.

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“…In the PARADIGM-HF trial, the primary outcome of cardiovascular mortality was decreased by 20% in the sacubitril-valsartan arm compared to the enalapril arm [9]. The various beneficial effects of ARNI in cardiac re-modelling, cardiac function, metabolic effects and decreased SCD have been well documented [10]. Thus, ARNI treatment has an important role in the therapy for HF [11].…”

Section: Introductionmentioning

confidence: 99%

Heart Failure Registries in Asia – What Have We Learned?

Balagopalan,

Abdullakutty

2024

CVIA

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Heart Failure (HF) is one of the leading problems in cardiology practice today. Acute decompensated heart failure (ADHF) is a significant cause of mortality and morbidity worldwide, and this is more relevant in the Asian subcontinent with a high population burden. Various regional registries in Asia have given us valuable insight into the aetiology and outcomes in this context. Though there are regional differences, it is clear from the review carried out in this paper that HF affects a much younger population. The comorbidities like diabetes and hypertension are high. Chronic kidney disease and atrial fibrillation are higher compared to the Western cohort. Heart failure with preserved ejection fraction is less often seen. The in-hospital mortality ranges from 2.8% to 8.4%. The one-year mortality is higher, and re-hospitalization is very high. Though in many Asian countries, guideline-directed medical therapy is initiated in hospitals, adherence is low. This is the challenge, and the way forward is only a practical team-based heart failure treatment approach. In the modern-day world of digital technology, the onus is on us to develop an integrated system of care in HF. This is by using available resources and opening up HF clinics. This review compares the strengths and limitations of various heart failure registries conducted in Asia and also gives a direction to plan effective strategies for improving heart failure care.

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The Benefits of Sacubitril-Valsartan in Low Ejection Fraction Heart Failure

Cited by 6 publications

References 60 publications

Prevalence of, association with, severity of, and prognostic role of serum hemoglobin level in acutely decompensated heart failure patients

Prevalence of, association with, severity of, and prognostic role of serum hemoglobin level in acutely decompensated heart failure patients

Left Bundle Branch Ablation Guided by a Three-Dimensional Mapping System: A Novel Method for Establishing a Heart Failure Animal Model

Heart Failure Registries in Asia – What Have We Learned?

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