The Benign Monoclonal Gammapathies: A Study of Monoclonal Antibodies

Waldenström, Jan

doi:10.1007/978-3-642-68546-0_2

Ergebnisse Der Inneren Medizin Und Kinderheilkunde / Advances in Internal Medicine and Pediatrics

1982

DOI: 10.1007/978-3-642-68546-0_2

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The Benign Monoclonal Gammapathies: A Study of Monoclonal Antibodies

Jan Waldenström¹

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Cited by 4 publications

References 134 publications

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Lymphocytic plasmocytoid lymphoma with a three-banded gammopathy: Reactivity of one of these paraproteins with cytomegalovirus

Köhler

Daus

Köhler

et al. 1987

Blut

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We report the case of a 70-year-old woman suffering from small lymphocytic, plasmocytoid lymphoma with abdominal lymphomas and infiltration of the lung and the bone marrow. A three-banded, IgG lambda, IgM lambda and IgA lambda-paraproteinemia was determined using immunofixation. Because of the patient's high antibody titre against cytomegalovirus (CMV), the possible reactivity of these paraproteins with CMV was studied. The immunoglobulins were transferred to nitrocellulose sheets by a contact diffusion blotting system. CMV was applied to these sheets and the IgG lambda-paraprotein was shown to bind CMV. The reactivity of only one of the paraproteins with CMV suggests an oligoclonal origin of this gammopathy. In addition to the malignant disease an abnormal immune response to a CMV infection could be the cause of this three-banded gammopathy.

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Lymphocytic plasmocytoid lymphoma with a three-banded gammopathy: Reactivity of one of these paraproteins with cytomegalovirus

Köhler

Daus

Köhler

et al. 1987

Blut

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Some reflections on myeloma

Waldenström

1985

Scandinavian Journal of Haematology

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Lymphoproliferations in the bone marrow: identification and evolution, classification and staging.

Bartl¹,

Frisch²,

Burkhardt³

et al. 1984

Journal of Clinical Pathology

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SUMMARY Bone marrow biopsies from 3229 patients with lymphoproliferative disorders and 1156 patients with benign or reactive lymphoproliferations were investigated and criteria for distinguishing between them are given. Bone marrow involvement was found in 89% of multiple 'myeloma, 64% of non-Hodgkin's lymphomas and 8% of Hodgkin's disease. According to the predominant proliferative cell type there were five major entities in multiple myeloma and non-Hodgkin's lymphomas: (1) plasmacytic; (2) lymphocytic; (3) hairy cell; (4) immunocytic; (5) centrocytic. These were further classified into distinct subtypes each of which had independent prognostic significance. The mode of spread of the lymphoproliferative disorders in the bone marrow showed one of six architectural patterns, which together with the quantity of infiltration in the biopsy (reflecting the tumour cell burden) had significant predictive value. These results demonstrate the value of bone marrow biopsies in the identification, classification and staging of lymphoproliferative disorders, as well as in monitoring the course of disease and the response to therapy.

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The Benign Monoclonal Gammapathies: A Study of Monoclonal Antibodies

Cited by 4 publications

References 134 publications

Lymphocytic plasmocytoid lymphoma with a three-banded gammopathy: Reactivity of one of these paraproteins with cytomegalovirus

Lymphocytic plasmocytoid lymphoma with a three-banded gammopathy: Reactivity of one of these paraproteins with cytomegalovirus

Some reflections on myeloma

Lymphoproliferations in the bone marrow: identification and evolution, classification and staging.

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