2‐Chloro‐1‐methylbenzimidazole reacts with various phenols to yield the corresponding ethers. 1H‐NMR‐spectra of these compounds were studied in deuteriochloroform and trifluoroacetic acid. Fragmentation of one of the ethers in the mass spectrometer is discussed. Anti‐inflammatory studies for compounds 2 are reported.
2‐Chloro‐1‐methylbenzimidazole reacts with various phenols to yield the corresponding ethers. 1H‐NMR‐spectra of these compounds were studied in deuteriochloroform and trifluoroacetic acid. Fragmentation of one of the ethers in the mass spectrometer is discussed. Anti‐inflammatory studies for compounds 2 are reported.
A convenient one-pot synthesis of 2¢-amino-and 2¢-N-phenylamino-5a-cholest-6-eno[6,7-d]thiazole derivatives 4-9 are reported. The synthesis involves the reaction of cholestan-6-ones 1-3 with thiourea or phenylthiourea and iodine. The products have been characterized on the basis of IR, 1 H-NMR and Mass, which find support in two cases from comparison with authentic samples.
1‐Alkyl‐3‐trifluoromethylpyrazole‐4‐sulfonamides 10, (2‐trifluoromethyl‐2,3‐dihydrobenzimidazol‐2‐yl)methanesulfonamides 12, and (2‐benzimidazolyl)metbanesulfonamides 13 were prepared starting from 3,3,3‐trifluoro‐2,2‐dihydroxypropanesulfonamides 1.
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