The Bethesda System for reporting thyroid cytopathology: A two year retrospective review in a tertiary care hospital

Shankar, Shanmuga Priya; Meenakshisundaram, K; Rajalakshmi, V; Selvakumar, Satish A; Giridharan, Bhanumathi

doi:10.5958/2394-6792.2016.00011.9

Cited by 3 publications

(6 citation statements)

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“…Although few studies have shown utility of cell blocks as an adjunct to conventional cytology in diagnosis of thyroid tumors [ 81 ], their use in everyday clinical practice is limited by their low cellularity, enhanced cost and turnover time [ 80 ]. As per the available literature, the technique is being done in routine only in rare centers across India [ 44 ].…”

Section: Ancillary Techniquesmentioning

confidence: 99%

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Thyroid Cytology in India: Contemporary Review and Meta-analysis

Agarwal

Jain²

2017

J Pathol Transl Med

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Fine-needle aspiration cytology (FNAC) is a screening test for triaging thyroid nodules, aiding in subsequent clinical management. However, the advantages have been overshadowed by the multiplicity of reporting systems and a wide range of nomenclature used. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was formulated in 2007, to give the world a uniform thyroid cytology reporting system, facilitating easy interpretation by the clinicians. Here, we review the status of thyroid FNAC in India in terms of various reporting systems used including a meta-analysis of the previously published data. An extensive literature search was performed using internet search engines. The reports with detailed classification system used in thyroid cytology were included. The meta-analysis of published data was compared with the implied risk of malignancy by TBSRTC. More than 50 studies were retrieved and evaluated. TBSRTC is currently the most widely used reporting system with different studies showing good efficacy and interobserver concordance. Ancillary techniques have, as of now, limited applicability and acceptability in thyroid cytology in India. Twenty-eight published articles met the criteria for inclusion in the meta-analysis. When compared with TBSRTC recommendations, the meta-analysis showed a higher risk of malignancy for categories I and III. Thyroid FNAC is practiced all over India. TBSRTC has found widespread acceptance, with most institutions using this system for routine thyroid cytology reporting. However, reasons for a high malignancy risk for categories I and III need to be looked into. Various possible contributing factors are discussed in the review.

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Section: Ancillary Techniquesmentioning

confidence: 99%

“… Forest plot of meta-analysis on the risk of malignancy for Bethesda category IV (follicular neoplasm/suspicious for a follicular neopla sm)[ 14 - 17 , 21 , 23 , 30 - 35 , 37 , 38 , 42 , 44 , 45 ,; 46 , 49 , 50 , 52 - 54 , 56 , 60 , 61 , 63 ]. ES, effect size ; CI, confidence interval.…”

Section: Figmentioning

confidence: 99%

Thyroid Cytology in India: Contemporary Review and Meta-analysis

Agarwal

Jain²

2017

J Pathol Transl Med

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“…The number of males in present study were 22 (8.8%) and the females were 228 (91.2%) with M:F ratio 1:10.3 which was comparable with study of Gharia et al Mehrotra et al and Shankar et al and who showed M:F ratio of 1:7.7 1:9.3 and 1:8.3 respectively. [2,6,7] While in Sharma et al study M:F ratio was 1:5.2. [3] In present study, maximum cases were of category II 219 (87.6%) cases which was comparable with studies conducted by Gharia et al, Shankar et al and Mehra et al they showed 165 cases (82.5%), 328 cases (81.6%) and 180 cases (80 %) cases respectively in their study.…”

Section: Discussionmentioning

confidence: 84%

“…[3] In present study, maximum cases were of category II 219 (87.6%) cases which was comparable with studies conducted by Gharia et al, Shankar et al and Mehra et al they showed 165 cases (82.5%), 328 cases (81.6%) and 180 cases (80 %) cases respectively in their study. [2,7,13] Annals of Pathology and Laboratory Medicine, Vol. 7, Issue 2, February, 2020…”

Section: Discussionmentioning

confidence: 99%

“…[3,6] Due to lack of a standardized system of reporting, pathologists have been using different terminologies thus creating confusion among clinicians in the interpretation of reports and further management. [7] To address the variability in terminology and other issues related to thyroid FNA, the National Cancer Institute proposed "Bethesda System for reporting of thyroid cytopathology"(TBSRTC). This system represents an important step toward standardization and reproducibility of Thyroid FNAC reporting its clinical significance and predictive value of thyroid FNA.…”

Section: Introductionmentioning

confidence: 99%

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Cytomorphological Study of Thyroid Nodule and Categorization According to The Bethesda System and Its Histopathological Correlation

Rupareliya

Patel

Bhagat

et al. 2020

APALM

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Background: Among an endocrine disorder, thyroid disorders are most commonly encountered disorder in routine clinical practice.Clinically it is quite difficult to evaluate thyroid lesion and reach clinical diagnosis.FNAC(Fine needle aspiration cytology) of thyroid is commonly performed and most effective tool for diagnosis and management of patient with thyroid nodule.Present study was conducted in department of pathology, government medical college, Surat.Our main aims and objectives are to report thyroid cytology smears by TBSRTC in to various diagnostic categories and to correlate these with histopathological findings. Material and Method:In the present study FNAC was performed on total 250 cases that were presented with thyroid swelling. These cases categorized according to TBSRTC and cytological diagnosis was correlated histopathologically in total 21 cases. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were calculated.Results: FNAC was carried out in 250 cases, diagnostic categories includes 5.20% non-diagnostic, 87.60% benign, 2.80% Atypia of Undetermined Significance or Follicular Lesion of Undetermined Significance, 2.40% follicular neoplasm or suspicious for follicular neoplasm, 1.60% suspicious for malignancy and 0.40% malignant lesions. Subsequent histopathological correlation was possible in 21 cases.In present study accuracy, sensitivity, specificity, positive predictive value and negative predictive value of FNAC in diagnosis of thyroid were 95%, 85.71%, 100%, 100% and 92.85% respectively. Conclusion:Standardized categorical Bethesda systems for reporting thyroid FNAC can make results easier to understand and interpret for clinicians and give clear indications for therapeutic action.

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Review of Three Cytology Reporting Systems in the Diagnosis of Thyroid Lesions: A Study of Fifty Cases

Chandanwale,

Bhide,

Rashmi

et al. 2023

Medical Journal of Dr. D.Y. Patil Vidyapeeth

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Background: The various reporting systems such as conventional system, UK/RC Path system, and The Bethesda System for Reporting Thyroid Cytology (TSBRTC) have been used to help create a standard reporting format for evaluating thyroid cytology smears. However, there is still an ongoing dispute as to which classification system is the best for the management of the patient with thyroid lesions. The aim of this study is to review the utility of three reporting systems in cytological evaluation of thyroid swellings. Materials and Methods: A total of 50 cases were included in study. Only adequate smears were included in the study. Cytology smears of all cases were reported and categorized as per three reporting systems. In cases in which surgical specimens were received for histopathological examination, diagnosis was correlated with cytology diagnosis. Results: Maximum patients (n = 27) were in the age group of 20–40 years. The comparison of conventional, TSBRTC, and UK/RC Path reporting systems of 50 thyroid cytology smears showed equivocal cases in the benign category (Category II). Conclusion: In the vast majority of the cases, it showed that TBSRTC and UK/RC Path system lead to better diagnostic yield, high sensitivity, and timely treatment of patients. TBSRTC has diagnostic accuracy of almost 98%. One of the most challenging categories was the Category III in TSBRTC or Thy3a which are heterogeneous category. The smears in these categories include features which do not permit them to be classified as either benign or malignant.

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The Bethesda System for reporting thyroid cytopathology: A two year retrospective review in a tertiary care hospital

Cited by 3 publications

References 0 publications

Thyroid Cytology in India: Contemporary Review and Meta-analysis

Thyroid Cytology in India: Contemporary Review and Meta-analysis

Cytomorphological Study of Thyroid Nodule and Categorization According to The Bethesda System and Its Histopathological Correlation

Review of Three Cytology Reporting Systems in the Diagnosis of Thyroid Lesions: A Study of Fifty Cases

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