The Better to Ear You With: Bioengineering Full-scale Auricles Using 3D-printed External Scaffolds and Decellularized Cartilage Xenograft

Vernice, Nicholas A.; Askinas, Carly Ann; Shih, Sabrina; Duan, Xue; Corpuz, George S.; Shin, James; Spector, Jason A.

doi:10.1097/01.gox.0000898480.09669.71

Cited by 3 publications

(1 citation statement)

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“…Examples are almost all cases involving the loss of cartilaginous external organs (nose, ear, larynx, trachea), the functional significance of which, in most cases, exists due to the complex structure and physiological characteristics of cartilaginous tissue. The ideal solution to this problem would be the use of composite, 3D-engineered biomaterials that would structurally mimic the normal organ and combine compatible materials with different cell types that would individually line each epithelial surface [ 125 , 126 ]. Although large and complex scaffolds are still in the experimental stage, clinical studies in patients with nasal cartilaginous defects showed excellent results.…”

Section: Adsc-exo Applications In Tissue Engineeringmentioning

confidence: 99%

Clinical Applications of Adipose-Derived Stem Cell (ADSC) Exosomes in Tissue Regeneration

Papadopoulos,

Piperi,

Korkolopoulou

2024

IJMS

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Adipose-derived stem cells (ADSCs) are mesenchymal stem cells with a great potential for self-renewal and differentiation. Exosomes derived from ADSCs (ADSC-exos) can imitate their functions, carrying cargoes of bioactive molecules that may affect specific cellular targets and signaling processes. Recent evidence has shown that ADSC-exos can mediate tissue regeneration through the regulation of the inflammatory response, enhancement of cell proliferation, and induction of angiogenesis. At the same time, they may promote wound healing as well as the remodeling of the extracellular matrix. In combination with scaffolds, they present the future of cell-free therapies and promising adjuncts to reconstructive surgery with diverse tissue-specific functions and minimal adverse effects. In this review, we address the main characteristics and functional properties of ADSC-exos in tissue regeneration and explore their most recent clinical application in wound healing, musculoskeletal regeneration, dermatology, and plastic surgery as well as in tissue engineering.

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Section: Adsc-exo Applications In Tissue Engineeringmentioning

confidence: 99%