The Betti base: the awakening of a sleeping beauty

Bioactivity of a Family of Chiral Nonracemic Aminobenzylnaphthols towards Candida albicans

“…Previously, some papers [14][15][16][17][18][19] reported the Betti reaction as a route for the asymmetric synthesis of chiral nonracemic amino benzylnaphthols. This procedure is a straightforward condensation of 2-naphthol, aryl aldehydes and suitable chiral nonracemic amines (Schemes 1 and 2) to yield more complex molecular structures.…”

Selective Synthesis and Structural Confirmation of 1,3‐Oxazines and Schiff Bases with Controllable Substitution Patterns

“…The preparation of substituted Betti bases (aminobenzyl derivatives) in this way is considerably advantageous because the C À C bond is formed under mild reaction conditions. [8] As a result of this, interest in the chemistry of the Betti base has increased multifold in recent times. [9][10][11] The preparation of the chiral Betti base and its N-substituted derivatives is important as these compounds can serve as chiral catalysts.…”

Fe3O4@SiO2–ZrCl2‐MNPs: A novel magnetic catalyst for the clean and efficient cascade synthesis of 1‐(benzothiazolylamino)methyl‐2‐naphthol derivatives in the absence of solvent

“…Betti 0 s base derivatives [1-(a-aminoalkyl)-2-naphthols] have provided comfortable access to many effective synthetic building blocks via the amino and phenolic hydroxy functional groups. [11] Because of this, the synthesis of 1-(benzothiazolylamino)methyl-2-naphthols is a significant and beneficial duty in organic chemistry processes. The majority of the novel heterogenized catalysts are based on magnetic nanoparticles (MNPs) Fe 3 O 4 supports, primarily because Fe 3 O 4 displays some advantageous properties, such as readily availability, relatively large surface area to volume ratio, heterogeneous characteristics and recoverability using an external permanent magnet.…”