The bidesmosidic triterpene saponins hederacoside C and ginsenoside Rb1 exhibit low affinity to cholesterol in liposomal membranes

Groot, Carolin de; Müsken, Mathias; Müller‐Goymann, Christel C.

doi:10.1016/j.jddst.2019.101127

Cited by 3 publications

(1 citation statement)

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“…Thanks to their surface activity and taste-modifying properties (sweet or bitter taste), often combined with high biological activity, saponins find numerous applications in the food, cosmetic, and pharmaceutical industries. For pharmaceutical applications, the saponin-cholesterol interaction, described for the first time more than a century ago [17,18], is especially important [19][20][21][22][23][24][25][26][27]. For many years, precipitation of cholesterol by a steroid saponin, digitonin, was even a basis of quantitative analysis of cholesterol in blood [28].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of Quillaja saponaria Saponins towards Lung Cells Is Higher for Cholesterol-Rich Cells

et al. 2021

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The purpose of the study was to compare cytotoxicity of two Quillaja saponaria bark saponin (QBS) mixtures against two lung cell lines: normal MRC-5 fibroblast cell line and tumor A-549 epithelial cells of lungs’ alveoli. The study, performed both at a macro-scale and in a dedicated microfluidic device, showed that QBS was more toxic to the cell line more abundant in cholesterol (MRC-5). The QBS mixture with higher saponin fraction was found to be more cytotoxic towards both cell lines. The results may help to better understand the cytotoxicity of saponin-rich herbal medicines towards normal and tumor cells depending on their cholesterol content.

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