The Bidirectional Relationship Between Asthma and Obstructive Sleep Apnea: Which Came First?

Min, Yap Zhi; Subbarao, Padmaja; Narang, Indra

doi:10.1016/j.jpeds.2016.05.058

Cited by 25 publications

(16 citation statements)

References 40 publications

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“…There is, in fact, evidence of a bidirectional relationship between the two disease processes. 7 Wheezing and asthma symptoms often coexist with symptoms of OSA. A common symptom between the two disease processes is nocturnal dyspnea.…”

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confidence: 99%

Pediatric Obstructive Sleep Apnea and Asthma: Clinical Implications

Trivedi¹,

ElMallah²,

Bailey³

et al. 2017

Pediatr Ann

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Obstructive sleep apnea (OSA) and asthma are common conditions in children with preventable long-term consequences. There is significant overlap in symptomatology and pathophysiology for pediatric OSA and asthma. Recent evidence supports clear associations between the two diseases; however, causality has not been demonstrated. Regardless, it is important to recognize the overlap and evaluate for the other condition when one is present. For example, in patients with severe OSA, clinical evaluation for asthma should be considered, including history for typical asthma symptoms and spirometry. For patients with severe or poorly controlled asthma, OSA should be considered as a complicating condition. Clinical history for OSA as well as pediatric sleep questionnaires may be helpful tools in evaluation of the child with severe asthma. To decrease long-term consequences from asthma and OSA in children, clinicians should consider the relationship between these two diseases. [Pediatr Ann. 2017;46(9):e332-e335.].

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confidence: 99%

Pediatric Obstructive Sleep Apnea and Asthma: Clinical Implications

Trivedi¹,

ElMallah²,

Bailey³

et al. 2017

Pediatr Ann

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“…Thus, treatment of asthma may improve nocturnal symp-toms in children with SDB and treatment of asthmatic children with SDB (e.g. adenotonsillectomy) may improve asthma exacerbations 35,36 . This is what sustains the theory of the "single airway", a continuous of respiratory pathologies 37 .…”

Section: Discussionmentioning

confidence: 99%

Trastornos respiratorios del sueño en niños escolares chilenos: prevalencia y factores de riesgo

Sánchez

Rojas

Casals

et al. 2018

Rev. chil. pediatr.

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Objectives:To describe the prevalence of sleep-disordered breathing (SDB) in Chilean schoolchildren and study associated risk factors. Patients and Method: We carried out a transversal and descriptive study. Questionnaires were sent to the parents of children attending first year of elementary school in the Metropolitan Region (Santiago), the Biobío Region (Concepción, Chillán, Yumbel) and the Magallanes Region (Porvenir and Puerto Natales). Anthropometric data, school performance, household characteristics, indoor pollutants, medical history, and current symptoms of asthma, allergic rhinitis, and atopic dermatitis were recorded. The nutritional status was determined according to z-BMI. A pediatric sleep questionnaire validated in Spanish (PSQ) was applied. Results: 564 questionnaires were analyzed, the median age was six years (range 5 to 9), 44.9% male. The SDB prevalence was 17.7% (n = 100): 6% in Vitacura (Metropolitan Region), 28.7% in Chillán (Biobío Region), and 36.4% in Puerto Natales (Magallanes Region) (p = 0.001). The group with SDB had a higher proportion of men (54.5 vs 42.8%, p = 0.033), lower academic performance (overall grade point average 6.36 ± 0.48 vs 6.56 ± 0.34, p = 0.001), lower maternal higher education (44.4% vs 69.9%, p = 0.001), and higher exposure to indoor pollutants than those without SDB. After the multivariate analysis, symptoms of rhinitis in the last 12 months (OR 4.79,) and lower maternal educational level (OR 3.51; 95% CI 1.53-8.02) remained as predictors of SDB. Conclusions: Chilean schoolchildren have a high prevalence of SDB with demographic differences. It was associated with social risk factors, more specific factors of lung damage, and worse sleep quality and quantity.

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“…Asthma and obstructive sleep apnea (OSA) have been reported to coexist and contribute to an overlap syndrome where a bidirectional relationship may negatively affect the other condition [ 119 , 120 , 121 ]. A recent meta-analysis has revealed that the prevalence of OSA and OSA risk in adult asthmatic patients is 50% and 27.5%, respectively, and the odds of having OSA or OSA risk is 2.64 and 3.73 times higher in asthmatic patients than in non-asthmatic patients [ 122 ].…”

Section: Detrimental Effects Of Hypercapnia In Asthmamentioning

confidence: 99%

Hypercapnia: An Aggravating Factor in Asthma

Shigemura

Homma

Sznajder

2020

JCM

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Asthma is a common chronic respiratory disorder with relatively good outcomes in the majority of patients with appropriate maintenance therapy. However, in a small minority, patients can experience severe asthma with respiratory failure and hypercapnia, necessitating intensive care unit admission. Hypercapnia occurs due to alveolar hypoventilation and insufficient removal of carbon dioxide (CO2) from the blood. Although mild hypercapnia is generally well tolerated in patients with asthma, there is accumulating evidence that elevated levels of CO2 can act as a gaso-signaling molecule, triggering deleterious effects in various organs such as the lung, skeletal muscles and the innate immune system. Here, we review recent advances on pathophysiological response to hypercapnia and discuss potential detrimental effects of hypercapnia in patients with asthma.

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The Bidirectional Relationship Between Asthma and Obstructive Sleep Apnea: Which Came First?

Cited by 25 publications

References 40 publications

Pediatric Obstructive Sleep Apnea and Asthma: Clinical Implications

Pediatric Obstructive Sleep Apnea and Asthma: Clinical Implications

Trastornos respiratorios del sueño en niños escolares chilenos: prevalencia y factores de riesgo

Hypercapnia: An Aggravating Factor in Asthma

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