The Big Role of Small RNAs in Anxiety and Stress-Related Disorders

Malan‐Müller, Stefanie; Hemmings, Sı̂an M.J.

doi:10.1016/bs.vh.2016.08.001

Cited by 9 publications

(7 citation statements)

References 167 publications

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“…maternal separation, low maternal care, chronic unpredictable stress, chronic mild stress) during different time windows of development (prior to conception, prenatal, postnatal, juvenile, adult age) in anxiety‐relevant brain regions (limbic system, cortical system, hippocampus) (for a comprehensive overview of the current status of stress‐ and anxiety‐related epigenetic research in animal models, please see Jawahar et al . ; Malan‐Muller & Hemmings ; Nieto et al . ).…”

Section: Epigenetics – the ‘Missing Link’?mentioning

confidence: 99%

“…MicroRNAs have been another target of epigenetic investigation in anxiety disorders and anxiety‐related dimensional phenotypes (for review, see Hommers et al . ; Martinetz ; Malan‐Muller & Hemmings ). For instance, variation in microRNAs miR‐22, miR‐138‐2, miR‐148a and miR‐488 were found to be associated with PD or panic‐related phenotypes (Muinos‐Gimeno et al .…”

Section: Epigenetics – the ‘Missing Link’?mentioning

confidence: 99%

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Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders

Schiele

Domschke

2017

Genes Brain and Behavior

159

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The pathogenesis of anxiety disorders is multifactorial, involving complex interactions between biological factors, environmental influences and psychological mechanisms. Recent advances have highlighted the role of epigenetics in bridging the gap between multiple contributing risk factors toward an increased understanding of the pathomechanisms underlying anxiety. In this review, we present an overview of the current state of knowledge regarding putative risk mechanisms in the pathogenesis of anxiety disorders, placing a particular focus on the role of protective factors serving to buffer a risk factor constellation and the role of epigenetic processes functioning as a potent turnstile changing passage direction toward disorder risk or resilience. We discuss promising future directions in epigenetic research regarding the prediction, prevention and personalized treatment of anxiety disorders.

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Section: Epigenetics – the ‘Missing Link’?mentioning

confidence: 99%

Section: Epigenetics – the ‘Missing Link’?mentioning

confidence: 99%

Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders

Schiele

Domschke

2017

Genes Brain and Behavior

159

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“…In the absence of perfect complementarity, the target is "deadenylated", resulting in the depletion of the target mRNA and subsequent exonucleolytic digestion or translational suppression (a different mechanism at each translation step, ie initiation, elongation and termination). [12] Mature miRNAs regulate target gene expression at both transcriptional and translational levels. [13] Given the key role of miRNAs in mediating biological events, any disruption in their expression may cause impaired homeostasis, which is reflected as an imbalance in the regulatory network that can distinguish between normal and disease states.…”

Section: Mirna Biogenesismentioning

confidence: 99%

“…One of the obstacles in the treatment of these multi-factor, complex and heterogeneous disorders; the genetic architecture of these disorders is not yet fully elucidated. [12] Molecular intervention or disruption of neuronal miRNAs in model systems is an important strategy to understand the effect of irregularities in gene expression networks in psychiatric disorders. [6] The purpose of this review is; to talk about the role and importance of miRNAs in synaptic plasticity and CNS neurogenesis and to review the studies with some psychiatric and neurodegenerative disorders systematically with current literature reviews.…”

Section: Introductionmentioning

confidence: 99%

Bazı Psikiyatrik ve Nörodejeneratif Bozuklukların Tanısında Potansiyel Bir Biyobelirteç MikroRNA’ ların İncelenmesi

Akat

Vatansev

Karaoğlu

2020

Journal of Contemporary Medicine

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MicroRNAs (miRNAs) are a large endogenous, noncoding RNA class of 19-25 nucleotides. Mature miRNAs regulate target gene expression at both transcriptional and translational levels. As a current area of interest in molecular diagnostic research, microRNAs (miRNAs) have recently been shown to be effective circulatory biomarkers for many diseases. Major depressive disorder, Bipolar disorder, Schizophrenia, Obsessive compulsive disorder, Alzheimer's disease and Parkinson's disease are among the most common psychiatric and neurodegenerative disorders known to be a serious public health problem in terms of morbidity, mortality and functional handicap. MicroRNAs are aware of the events occurring in the cell as normal mechanical, physical and biochemical functions due to many psychiatric and other medical diseases, and are very promising as a biomarker for emerging disorders and neuropathological changes.

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“…A considerable number of miRNAs are expressed in human brain [12] and are known to play important roles in various psychiatric diseases including depressive disorders [13], autism [14], anxiety and stressrelated disorders [15], bipolar disorder and schizophrenia [16]. Importantly, miRNAs can act as epigenetic regulators in post-traumatic stress disorders [17,18].…”

Section: Introductionmentioning

confidence: 99%

A Functional SNP rs895819 on Pre-miR-27a is Associated with Bipolar Disorder by Targeting ICAM-1.

Yang¹,

Lu²,

Mei³

et al. 2021

Preprint

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Aberrant expression or genomic mutations of microRNA have been reported to be associated with a variety of human diseases. This study is aimed to analyze the association between genetic variations of miRNA and schizophrenia or bipolar disorder. We performed case-control studies for ten SNPs in a total sample of 1584 Chinese subjects. All these ten SNPs are on or near mature microRNAs which are expressed in the brain. To illustrate the function of miR-27a, we constructed a miR-27a knockout (KO) astrocytoma cell line U-251MG. By comparing the differentially expressed genes in wild-type and KO U-251MG, we determined several candidate target genes of miR-27a and then verified ICAM-1 as a target gene of miR-27a. We identified the association between the T/C polymorphism at rs895819 and bipolar disorder. Ectopic expression of miR-27a in NPCs showed that the T to C mutation at rs895819 reduced the suppressive effects of miR-27a on the expression of its target genes. Further studies revealed that the T/C polymorphism on miR-27a led to differential expression of mature and precursor miR-27a without affecting the expression of primary miR-27a. Our study highlighted the importance of miR-27a and its polymorphism at rs895819 in bipolar disorder.

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The Big Role of Small RNAs in Anxiety and Stress-Related Disorders

Cited by 9 publications

References 167 publications

Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders

Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders

Bazı Psikiyatrik ve Nörodejeneratif Bozuklukların Tanısında Potansiyel Bir Biyobelirteç MikroRNA’ ların İncelenmesi

A Functional SNP rs895819 on Pre-miR-27a is Associated with Bipolar Disorder by Targeting ICAM-1.

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