The bimolecular sensitization of nitric oxide release from weak interacting ruthenium units

Ruthenium-nitrosyl complexes as NO-releasing molecules, potential anticancer drugs, and photoswitches based on linkage isomerism

“…In the series of cis-[Ru(bpy) 2 (NO)X] n+ complexes, the backbonding in {Ru-NO} 6 (Ru II -NO + ), and the electron density on the nitrosyl ligand augments with increasing σ-and π-donor character of the X ligand under the metal ion, and results in a decrease of the E 1 (NO + /NO 0 ) and ν NO similar to that in trans-tetrammine complexes (vide supra). In aqueous solution, chemical reduction of the cis/trans-[Ru(bpy) 2 (NO)X] n+ 168,169,170,171,172,173 as well as related complexes [Ru(tpy)(NO)L] n+ 174 (tpy = terpyridine) released NO, as attested by measurement with an NO sensor. The k-NO rate constants were similar for the whole group but generally lower than those for the tetrammines.…”

“…In aqueous solution, chemical reduction of the cis/trans-[Ru(bpy) 2 (NO)X] n+ (ref. [168][169][170][171][172][173] as well as related complexes [Ru(tpy)(NO)L] n+ (ref. 174) (tpy = terpyridine) released NO, as attested by measurement with an NO sensor.…”

Enhanced Antitumor Activity against Melanoma Cancer Cells by Nitric Oxide Release and Photosensitized Generation of Singlet Oxygen from Ruthenium Complexes

“…Employing compounds that display relatively low thermal reactivity and that could act as NO delivery agents upon external stimulation could emerge as a new approach to cancer treatment. It has been reported that nitrosylruthenium complexes can act as NO delivery agents upon irradiation with light, which could be useful in cancer therapy studies . Recently, our research team found that the irradiation of an aqueous solution containing [Ru(NH 3 ) 5 (pyrazine)] 2+ ( I ) and trans ‐[RuCl([15]aneN 4 )NO] 2+ ( II ; Figure ) with light in the region of 450 nm produces singlet oxygen ( 1 O 2 ) and NO, respectively , .…”