The binding of Ca2+ to the cell membrane increased by volatile anesthetics (alcohols, acetone, ether) which induce sensitization of nerve or muscle

Seeman, Philip; Chau, Mokit; Goldberg, M A; Sauks, T.; Sax, L.

doi:10.1016/0005-2736(71)90211-2

Cited by 76 publications

(2 citation statements)

References 17 publications

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“…Other studies have been conducted to explore the effects of general anesthetics on cell Ca content, since Ca ions are known to be involved in the regulation of many processes including voltage-dependent and neurotransmitterinduced ion fluxes and transmitter release from nerve endings. Sensitization of nerve terminals or muscle by volatile anesthetics has been related to increased Ca2" binding, as observed in erythrocyte ghost membranes (Seeman et al, 1971). However, it was also found that all anesthetics, regardless of charge or molecular geometry, deplete the red cell membrane to the same level of residual Ca, except at low concentrations of straight chain alcohols (Low et al, 1979).…”

Section: Introductionmentioning

confidence: 99%

Increases in internal Ca2+ and decreases in internal H+ are induced by general anesthetics in squid axons

Vassort¹,

Whittembury²,

Mullins³

1986

Biophysical Journal

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Squid axons were injected with arsenazo III and treated with sea water containing compounds usually classified as general anesthetics, (pentanol-decanol and a variety of hydrocarbons and their derivatives). Such treatment led to an increase in absorbance by arsenazo III at wavelengths sensitive to [Ca]i. The effect was independent of the presence or absence of Ca++ in sea water and it was not modified by substances that release Ca from internal stores. The effect was easily reversible. In axons injected with phenol red or impaled with a glass electrode sensitive to H+, a similar treatment led to an alkalinization that was also readily reversible. Both Ca release and the change to an alkaline pH had identical time courses. The dose required for action by all of the chemical agents studied could be predicted from a knowledge of their fractional saturation in sea water, i.e. from their thermodynamic activity. For compounds with 8-10 carbon atoms, Ca-release effects can occur at concentration less than those necessary to block either conduction or Na/Ca exchange. A special chemical agent was octylamine, which induced a marked rise in pHi and in addition its nonionic form produced the typical Ca release associated with general anesthetics.

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Section: Introductionmentioning

confidence: 99%

Increases in internal Ca2+ and decreases in internal H+ are induced by general anesthetics in squid axons

Vassort¹,

Whittembury²,

Mullins³

1986

Biophysical Journal

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“…Ross and coworkers found ethanol to cause the displacement of calcium from synaptosomes both in vivo and in vitro (Ross,1977;Ross et al, 1979). Other workers have found ethanol to increase in vitro calcium binding (Seeman et al, 1971; Michaelis and Myers, 1979). S t i l l other groups have reported ethanol to have no effect on in vivo membranes (Hood and Harris, 1979;Ferko and Bobjock, 1980) .…”

Section: Electrophysiological Studies Indicate Golgi Cellsmentioning

confidence: 99%

Ethanol effects on the olivocerebellar system

Sinclair¹,

Lo²,

Harris³

1982

Can. J. Physiol. Pharmacol.

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Ethanol (1.5 g/kg i.v.) was found to decrease spontaneous complex spike (CS) activity in cerebellar Purkinje cells in urethane anaesthetized rats while not changing the threshold required to evoke a CS by juxtafastigial stimulation. Thus ethanol does not decrease CS activity by an action at the climbing fibre-Purkinje cell synapse. Tremor induced by harmaline (5 mg/kg i.v.) in unanaesthetized animals was markedly antagonized by ethanol (0.5-2.0 g/kg i.v.) in all animals tested. However, in nine urethane-anaesthetized animals, ethanol markedly reversed the effects of harmaline on Purkinje cells in only two cases and partially reversed the effects in another four cells. Thus, the depressant effects of ethanol on the inferior olive is not total responsible for the blockade of the harmaline tremor bur would account for the decrease in spontaneous CS activity.

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Linear Relationships between Lipophilic Character and Biological Activity of Drugs

Hansch¹,

Dunn²

1972

Journal of Pharmaceutical Sciences

438

102

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The binding of Ca2+ to the cell membrane increased by volatile anesthetics (alcohols, acetone, ether) which induce sensitization of nerve or muscle

Cited by 76 publications

References 17 publications

Increases in internal Ca2+ and decreases in internal H+ are induced by general anesthetics in squid axons

Increases in internal Ca2+ and decreases in internal H+ are induced by general anesthetics in squid axons

Ethanol effects on the olivocerebellar system

Linear Relationships between Lipophilic Character and Biological Activity of Drugs

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