The binding of soybean agglutinin (SBA) to the intestinal epithelium of Atlantic salmon, Salmo salar and Rainbow trout, Oncorhynchus mykiss, fed high levels of soybean meal

Buttle, L.; Burrells, Alison; Good, Joanne E; Williams, Paul; Southgate, Peter; Burrells, C.

doi:10.1016/s0165-2427(01)00269-0

Cited by 137 publications

(94 citation statements)

References 11 publications

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“…Since then, innumerable feeding trials using various animal models have confirmed that legume lectins contribute substantially to the nutritional toxicity of many raw legumes. Binding of soybean lectin (agglutinin; SBA) to carbohydrate moieties of glycoconjugates, specifi cally to N-acetyl-d-galactosamine, on the intestinal brush border membr ks et al, ants d net protein tilization) in rats and in vitro hemagglutinating activity (rabbit, pronase-treated rat, trypsin -8) ane of Atlantic salmon and rainbow trout has been demonstrated (Hendric 1990;Buttle et al, 2001), in which higher maximum binding and lower dissociation const were observed in the distal intestine relative to the more proximal areas (Hendricks et al, 1990). These authors suggested that this could indicate that the distal intestine would be more sensitive to a potentially toxic effect of soybean lectin or other antinutritional factors or antigens.…”

Section: Biological Effects In Fish General Considerationsmentioning

confidence: 99%

“…The non-toxic legumes showed varying degrees of hemagglutination activity but generally acceptable net protein utilization by the rats at both levels of legume inclusion and 100 g seed protein kg -1 ) in the experimental diets. Maximum inclusion level of lectins from various plant protein sources have not been determined and will most likely vary considerably betw ated by the discussion above and (Buttle et al, 2001). Indeed, inclusion levels of solvent-extracted soybean meal as low as 100 g per kg feed have been demonstrated to cause histological changes and digestive disturbances in Atlantic salmon .…”

Section: Biological Effects In Fish General Considerationsmentioning

confidence: 99%

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Criteria for Safe Use of Plant Ingredients in Diets for Aquacultured Fish

Hemre

Amlund

Aursand

et al. 2018

EJNFS

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Section: Biological Effects In Fish General Considerationsmentioning

confidence: 99%

Section: Biological Effects In Fish General Considerationsmentioning

confidence: 99%

Criteria for Safe Use of Plant Ingredients in Diets for Aquacultured Fish

Hemre

Amlund

Aursand

et al. 2018

EJNFS

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“…For instance, there are many anti-nutritional substances in soybean, and these are suspected to induce allergy and alter the growth of fish. It is reported that feeding rainbow trout with high levels (60%) of soya or offering Atlantic salmon with 3.5% soybean agglutinin led to binding of the agglutinin to the intestinal enterocytes, which in turn caused aberrations of the intestinal structure of the carnivorous fishes (Buttle et al, 2001). One of the antinutritional factors, β-conglycinin was found to decrease the antioxidant capacity indices such as SOD, CAT, glutathione-S-transferase, glutathione peroxidase and glutathione reductase activities and glutathione content in the intestine and enterocytes of juvenile Jian carp (Cyprinus carpio) .…”

Section: Health Status Upon Feeding Desmodesmus To Atlantic Salmonmentioning

confidence: 99%

Defatted Biomass of the Microalga, Desmodesmus sp., Can Replace Fishmeal in the Feeds for Atlantic salmon

et al. 2016

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Microalgal biomass is a potential feed ingredient that can replace fishmeal and ensure sustainability standards in aquaculture. To understand the efficacy of the defatted biomass from the marine microalga, Desmodesmus sp. a 70-day feeding study was performed with Atlantic salmon (Salmo salar) smolts. Three groups of fish (av. wt. 167 g) were offered either a control feed (without the microalga) or the microalga-containing (10/20%) feeds. At the end of the feeding period, the growth indices (condition factor, specific growth rate) and survival of the microalga-fed fish were not significantly different from the respective values of the control fish, but the feed conversion ratios were inferior. The proximate composition of the whole body of salmon from the three groups did not vary significantly. Compared to the control fish, the 10% alga-fed fish had lower lipid content in their filet. The protein and lipid digestibility in the three feeds did not differ significantly, but the digestibility of energy in the 10% alga-feed was significantly lower than that of the control feed. Furthermore, comparison of the distal intestinal proteome of Atlantic salmon revealed that the expressions of Alpha-2-HS-glycoprotein-like (Ahsg), Myosin-11 isoform X1 (My11) and Dihydrolipoyl dehydrogenase, mitochondrial-like (Dld) were altered by the microalgal feeding. Examination of the physiological status of the fish based on the serum antioxidant capacities did not reveal any alga-feed-related differences. Moreover, the expression of the selected immune and inflammatory marker genes and the micromorphological observations did not indicate any aberration in the intestinal health of the microalga-fed fish. It is possible to include 20% of defatted Desmodesmus sp. in the feeds of Atlantic salmon.

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“…Salmonids are genuine carnivores, and plant ingredients in their feed induce chronic intestinal inflammatory conditions characterized by increased mucosal leukocyte accumulations and epithelial cell proliferation in a dose-dependent manner (26)(27)(28)(29)(30)(31)(32). Further, vegetable oils rich in n-6 polyunsaturated fatty acids (PUFA) are known to facilitate intestinal inflammation in mammals (5), and their effect in salmon includes lower transcription levels of certain stress and antioxidant-related genes (33).…”

Section: Introductionmentioning

confidence: 99%