“…Whereas FKLF interacts with the CACCC box of the ␥-globin gene to activate its transcription (4,5), BCL11A functions as a silencer of the ␥-globin gene and associates with HS3 and the intergenic region between A␥-and ␦-globin genes to reconfigure the -like globin gene cluster (6,7). Additionally, other transcription factors, such as NF-E2 (8,9), GATA-1 (10), FOG (11), Sox6 (12), NF-E3 (13), SP1 (14,15), KLF3/BKLF (16,17), TR2, and TR4 (18), are involved in the control of -like globin gene expression. Although these studies represent significant advances in the understanding of -like globin gene regulation at the transcriptional level, only a few microRNAs (miRNAs) have been found to be regulators of the -like globin locus (19,20,21).…”