The Binge Eating Genetics Initiative (BEGIN): study protocol

Bulik, Cynthia M.; Butner, Jonathan; Tregarthen, Jenna; Thornton, Laura M.; Flatt, Rachael E.; Smith, Tosha Woods; Carroll, Ian M.; Baucom, Brian R.; Deboeck, Pascal R.

doi:10.1186/s12888-020-02698-7

Cited by 27 publications

(28 citation statements)

References 44 publications

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“…166 BEGIN will conduct a large GWAS in 2500 individuals with binge-type ED and matched controls, coupled with microbiota sampling, and deep phenotyping using an ED recovery application programmed on Apple watches. 167…”

Section: Discussionmentioning

confidence: 99%

Genetic risk factors for eating disorders: an update and insights into pathophysiology

Himmerich

Bentley

Kan

et al. 2019

Therapeutic Advances in Psychopharmacology

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Genome-wide-association studies (GWASs), epigenetic, gene-expression and gene-gene interaction projects, nutritional genomics and investigations of the gut microbiota have increased our knowledge of the pathophysiology of eating disorders (EDs). However, compared with anorexia nervosa, genetic studies in patients with bulimia nervosa and bingeeating disorder are relatively scarce, with the exception of a few formal genetic and smallsized candidate-gene-association studies. In this article, we review important findings derived from formal and molecular genetics in order to outline a genetics-based pathophysiological model of EDs. This model takes into account environmental and nutritional factors, genetic factors related to the microbiome, the metabolic and endocrine system, the immune system, and the brain, in addition to phenotypical traits of EDs. Shortcomings and advantages of genetic research in EDs are discussed against the historical background, but also in light of potential future treatment options for patients with EDs.

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Section: Discussionmentioning

confidence: 99%

Genetic risk factors for eating disorders: an update and insights into pathophysiology

Himmerich

Bentley

Kan

et al. 2019

Therapeutic Advances in Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…Participants from the United States (US) and the Netherlands (NL) were invited to take part in an online study. US participants were recruited via social media (e.g., Facebook, Twitter, Instagram advertisements, and the UNC Exchanges blog), or via emails to participants who consented to recontact from ongoing studies (Bulik et al, 2020; Thornton et al, 2018). NL participants were also recruited via social media and via the online platform Proud2Bme and the Dutch Eating Disorder Register (NER).…”

Section: Methodsmentioning

confidence: 99%

Early impact of COVID‐19 on individuals with self‐reported eating disorders: A survey of ~1,000 individuals in the United States and the Netherlands

Termorshuizen

Watson

Thornton

et al. 2020

Intl J Eating Disorders

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251

268

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Objective: We evaluated the early impact of COVID-19 on people with self-reported eating disorders. Method: Participants in the United States (US, N = 511) and the Netherlands (NL, N = 510), recruited through ongoing studies and social media, completed an online survey that included both quantitative measures and free-text responses assessing the impact of COVID-19 on situational circumstances, eating disorder symptoms, eating disorder treatment, and general well-being. Results: Results revealed strong and wide-ranging effects on eating disorder concerns and illness behaviors that were consistent with eating disorder type. Participants with anorexia nervosa (US 62% of sample; NL 69%) reported increased restriction and fears about being able to find foods consistent with their meal plan. Individuals with bulimia nervosa and binge-eating disorder (US 30% of sample; NL 15%) reported increases in their binge-eating episodes and urges to binge. Respondents noted marked increases in anxiety since 2019 and reported greater concerns about the impact of COVID-19 on their mental health than physical health. Although many participants acknowledged and appreciated the transition to telehealth, limitations of this treatment modality for this population were raised. Individuals with past histories of eating disorders noted concerns about relapse related to COVID-19 circumstances. Encouragingly, respondents also noted positive effects including greater connection with family, more time for self-care, and motivation to recover. Discussions: COVID-19 is associated with increased anxiety and poses specific disorder-related challenges for individuals with eating disorders that require attention by healthcare professionals and carers.

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“…US participants were recruited via social media (e.g., Facebook, Twitter, Instagram advertisements, and the UNC Exchanges blog), or via emails to participants who consented to recontact from ongoing studies. 17,18 NL participants were also recruited via social media and via the online platform Proud2Bme and the Dutch Eating Disorder Register (NER). The minimum age to participate without parental consent was 18 years in the US and 16 years in NL.…”

Section: Methodsmentioning

confidence: 99%

“…The copyright holder for this preprint this version posted June 8, 2020. ; https://doi.org/10.1101/2020.05.28.20116301 doi: medRxiv preprint Instagram advertisements, and the UNC Exchanges blog), or via emails to participants who consented to recontact from ongoing studies. 17,18 NL participants were also recruited via social media and via the online platform Proud2Bme and the Dutch Eating Disorder Register (NER).…”

Section: Participants and Proceduresmentioning

confidence: 99%

Early Impact of COVID-19 on Individuals with Eating Disorders: A survey of ~1000 Individuals in the United States and the Netherlands

Termorshuizen

Watson

Thornton

et al. 2020

Preprint

Self Cite

106

View full text Add to dashboard Cite

We received rapid ethical permission to evaluate the early impact of COVID-19 on people with eating disorders. Participants in the United States (US, N=511) and the Netherlands (NL, N=510), recruited through ongoing studies and social media, completed an online baseline survey that included both quantitative measures and free-text responses assessing the impact of COVID-19 on situational circumstances, eating disorder symptoms, eating disorder treatment, and general well-being. Results revealed strong and wide-ranging effects on eating disorder concerns and illness behaviors that were consistent with diagnoses. Participants with anorexia nervosa (US 62% of sample; NL 69%) reported increased restriction and fears about being able to find foods consistent with their meal plan. Individuals with bulimia nervosa and binge-eating disorder (US 30% of sample; NL 15%) reported increases in their binge-eating episodes and urges to binge. Respondents noted marked increases in anxiety since 2019 and reported greater concerns about the impact of COVID-19 on their mental health than physical health. Although many participants acknowledged and appreciated the transition to telehealth, limitations of this treatment modality for this population were raised. Individuals with past histories of eating disorders noted concerns about relapse related to COVID-19 circumstances. Encouragingly, respondents also noted positive effects including greater connection with family, more time for self-care, and motivation to recover.

show abstract

The Binge Eating Genetics Initiative (BEGIN): study protocol

Cited by 27 publications

References 44 publications

Genetic risk factors for eating disorders: an update and insights into pathophysiology

Genetic risk factors for eating disorders: an update and insights into pathophysiology

Early impact of COVID‐19 on individuals with self‐reported eating disorders: A survey of ~1,000 individuals in the United States and the Netherlands

Early Impact of COVID-19 on Individuals with Eating Disorders: A survey of ~1000 Individuals in the United States and the Netherlands

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